JP2005508613A5 - - Google Patents
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- JP2005508613A5 JP2005508613A5 JP2003510686A JP2003510686A JP2005508613A5 JP 2005508613 A5 JP2005508613 A5 JP 2005508613A5 JP 2003510686 A JP2003510686 A JP 2003510686A JP 2003510686 A JP2003510686 A JP 2003510686A JP 2005508613 A5 JP2005508613 A5 JP 2005508613A5
- Authority
- JP
- Japan
- Prior art keywords
- mycobacteria
- tuberculosis
- gene
- nutrient
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000008827 tuberculosis Diseases 0.000 claims 38
- 108090000623 proteins and genes Proteins 0.000 claims 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 239000002299 complementary DNA Substances 0.000 claims 14
- 238000011081 inoculation Methods 0.000 claims 14
- 230000002238 attenuated effect Effects 0.000 claims 12
- 238000000855 fermentation Methods 0.000 claims 12
- 230000004151 fermentation Effects 0.000 claims 12
- 230000001105 regulatory effect Effects 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 108091026890 Coding region Proteins 0.000 claims 7
- 235000003642 hunger Nutrition 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 235000015097 nutrients Nutrition 0.000 claims 7
- 230000037351 starvation Effects 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 5
- 230000000813 microbial effect Effects 0.000 claims 5
- 230000008488 polyadenylation Effects 0.000 claims 5
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 239000013612 plasmid Substances 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 206010062207 Mycobacterial infection Diseases 0.000 claims 3
- 102000004316 Oxidoreductases Human genes 0.000 claims 3
- 108090000854 Oxidoreductases Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims 2
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims 2
- 108090000301 Membrane transport proteins Proteins 0.000 claims 2
- 102000003939 Membrane transport proteins Human genes 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108010017378 prolyl aminopeptidase Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- VOJUXHHACRXLTD-UHFFFAOYSA-N 1,4-dihydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC(O)=C21 VOJUXHHACRXLTD-UHFFFAOYSA-N 0.000 claims 1
- 102000006027 3-hydroxyisobutyrate dehydrogenase Human genes 0.000 claims 1
- 108020003281 3-hydroxyisobutyrate dehydrogenase Proteins 0.000 claims 1
- 108010031096 8-amino-7-oxononanoate synthase Proteins 0.000 claims 1
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims 1
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims 1
- 108700016155 Acyl transferases Proteins 0.000 claims 1
- 102000057234 Acyl transferases Human genes 0.000 claims 1
- 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 101710134864 Chalcone synthase 2 Proteins 0.000 claims 1
- 102000005870 Coenzyme A Ligases Human genes 0.000 claims 1
- 102100026846 Cytidine deaminase Human genes 0.000 claims 1
- 108010031325 Cytidine deaminase Proteins 0.000 claims 1
- 102100034560 Cytosol aminopeptidase Human genes 0.000 claims 1
- 101710116957 D-alanyl-D-alanine carboxypeptidase Proteins 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241001521223 Escherichia virus HK97 Species 0.000 claims 1
- 108090000371 Esterases Proteins 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 108010063907 Glutathione Reductase Proteins 0.000 claims 1
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 claims 1
- 101710191718 Glycine betaine transporter Proteins 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 108010072039 Histidine kinase Proteins 0.000 claims 1
- 108090000604 Hydrolases Proteins 0.000 claims 1
- 102000004157 Hydrolases Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 claims 1
- 108050003084 Methylmalonate-semialdehyde dehydrogenases Proteins 0.000 claims 1
- 102000014241 Methylmalonate-semialdehyde dehydrogenases Human genes 0.000 claims 1
- 241000589343 Methylobacter luteus Species 0.000 claims 1
- 108090000691 Ornithine aminotransferases Proteins 0.000 claims 1
- 102000004132 Ornithine aminotransferases Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108010030678 Phosphatidylethanolamine N-Methyltransferase Proteins 0.000 claims 1
- 102000005920 Phosphatidylethanolamine N-methyltransferase Human genes 0.000 claims 1
- 108010064209 Phosphoribosylglycinamide formyltransferase Proteins 0.000 claims 1
- 102000015082 Phosphoribosylglycinamide formyltransferase Human genes 0.000 claims 1
- 101710146616 Prohead protease Proteins 0.000 claims 1
- 108700040121 Protein Methyltransferases Proteins 0.000 claims 1
- 102000055027 Protein Methyltransferases Human genes 0.000 claims 1
- 102000004879 Racemases and epimerases Human genes 0.000 claims 1
- 108090001066 Racemases and epimerases Proteins 0.000 claims 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 claims 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 claims 1
- 108090001033 Sulfotransferases Proteins 0.000 claims 1
- 102000004896 Sulfotransferases Human genes 0.000 claims 1
- 101710151847 Thiosulfate-binding protein Proteins 0.000 claims 1
- 108090000340 Transaminases Proteins 0.000 claims 1
- 102000003929 Transaminases Human genes 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 102000008579 Transposases Human genes 0.000 claims 1
- 108010020764 Transposases Proteins 0.000 claims 1
- 108010054269 Uridine Diphosphate Glucose Dehydrogenase Proteins 0.000 claims 1
- 102000057144 Uridine Diphosphate Glucose Dehydrogenase Human genes 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 102000005421 acetyltransferase Human genes 0.000 claims 1
- 108020002494 acetyltransferase Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 108010006025 bovine growth hormone Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- VLYUGYAKYZETRF-UHFFFAOYSA-N dihydrolipoamide Chemical compound NC(=O)CCCCC(S)CCS VLYUGYAKYZETRF-UHFFFAOYSA-N 0.000 claims 1
- 108020000862 enoyl-CoA hydratase/isomerase Proteins 0.000 claims 1
- 102000003630 enoyl-CoA hydratase/isomerase Human genes 0.000 claims 1
- 150000002185 fatty acyl-CoAs Chemical class 0.000 claims 1
- -1 glutaryl Chemical group 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- 108010040686 nitrilotriacetate monooxygenase Proteins 0.000 claims 1
- 108020003068 nitronate monooxygenase Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 claims 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 claims 1
- 229960001327 pyridoxal phosphate Drugs 0.000 claims 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
- 108010063664 uroporphyrin-III C-methyltransferase Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0116385A GB0116385D0 (en) | 2001-07-04 | 2001-07-04 | Mycobacterial antigens expressed during latency |
| GB0123993A GB0123993D0 (en) | 2001-10-05 | 2001-10-05 | Mycobacterial antigens expressed during latency |
| PCT/GB2002/003052 WO2003004520A2 (en) | 2001-07-04 | 2002-07-04 | Mycobacterial antigens expressed during latency |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508613A JP2005508613A (ja) | 2005-04-07 |
| JP2005508613A5 true JP2005508613A5 (enExample) | 2005-12-22 |
Family
ID=26246282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510686A Pending JP2005508613A (ja) | 2001-07-04 | 2002-07-04 | 潜伏中に発現されるマイコバクテリア抗原 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7393540B2 (enExample) |
| EP (2) | EP2196473A1 (enExample) |
| JP (1) | JP2005508613A (enExample) |
| AU (2) | AU2002314358C1 (enExample) |
| CA (1) | CA2453173C (enExample) |
| WO (1) | WO2003004520A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9806093D0 (en) * | 1998-03-20 | 1998-05-20 | Taylor John Hermon | Diagnostics and vaccines for mycobacterial infections of animals and humans |
| US7393539B2 (en) | 2001-06-22 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed under low oxygen tension |
| EP2196473A1 (en) | 2001-07-04 | 2010-06-16 | Health Protection Agency | Mycobacterial antigens expressed during latency |
| GB0125535D0 (en) * | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
| EP1523331B1 (en) * | 2002-07-13 | 2013-02-27 | Statens Serum Institut | Therapeutic tb vaccine |
| WO2004067718A2 (en) * | 2003-01-24 | 2004-08-12 | Emory University | Necrosis-deficient mutants of tuberculosis bacteria |
| ES2231037B1 (es) | 2003-10-31 | 2005-12-16 | Archivel Technologies, Sl | Agente inmunoterapico util para el tratamiento combinado de la tuberculosis en asociacion con otros farmacos. |
| WO2006104389A1 (en) * | 2005-03-31 | 2006-10-05 | Leiden University Medical Center | Methods and means for diagnostics, prevention and treatment of mycobacterium infections and tuberculosis disease |
| CA2606962A1 (en) * | 2005-04-29 | 2006-11-09 | Fusion Antibodies Limited | Assays for diagnosis of tuberculosis and uses thereof |
| AU2006261445B2 (en) * | 2005-06-23 | 2011-03-31 | Statens Serum Institut | Tuberculosis vaccines comprising antigens expressed during the latent infection phase |
| EP1910410B1 (en) | 2005-07-01 | 2011-10-26 | Forsyth Dental Infirmary for Children | Tuberculosis antigen detection assays and vaccines |
| EP1913020B1 (en) * | 2005-08-09 | 2010-05-05 | HAV Vaccines Limited | Immunogenic constructs |
| US7601357B2 (en) * | 2005-12-07 | 2009-10-13 | University Of Central Florida Research Foundation, Inc. | Targeting of long chain triacylglycerol hydrolase gene for tuberculosis treatment |
| CN101374964B (zh) * | 2005-12-09 | 2013-07-17 | 贝勒研究院 | 外周血液白细胞转录模式的模块水平分析 |
| NZ597557A (en) * | 2006-03-02 | 2013-10-25 | Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
| ES2307402B1 (es) | 2006-10-30 | 2009-09-30 | Archivel Farma, S.L. | Vacuna profilactica contra la tuberculosis. |
| MX2010014556A (es) * | 2008-06-25 | 2011-07-28 | Baylor Res Inst | Firma transcripcional de sangre por infeccion de mycobacterium tuberculosis. |
| US20110129817A1 (en) * | 2009-11-30 | 2011-06-02 | Baylor Research Institute | Blood transcriptional signature of active versus latent mycobacterium tuberculosis infection |
| US20100015171A1 (en) | 2008-07-15 | 2010-01-21 | Statens Serum Institute | Vaccines comprising tb 10.4 |
| ES2335177B1 (es) | 2008-09-19 | 2011-02-28 | Archivel Farma, S.L. | Agente inmunoterapeutico apropiado para la profilaxis primaria de la tuberculosis. |
| CN102713629B (zh) | 2009-11-20 | 2016-02-24 | 俄勒冈健康科学大学 | 用于检测结核分枝杆菌感染的方法 |
| GB201008512D0 (en) * | 2010-05-21 | 2010-07-07 | Health Prot Agency | Mycobacterial antigen composition |
| ITRM20100411A1 (it) * | 2010-07-23 | 2012-01-24 | Massimo Amicosante | Uso di sequenze amminoacidiche da mycobacterium tuberculosis o dei loro corrispondenti acidi nucleici per la diagnosi e la prevenzione di infezione tubercolare, relativo kit diagnostico e vaccino. |
| PL2661253T3 (pl) | 2011-01-04 | 2017-08-31 | Archivel Farma, Sl | Preparat liposomowy odpowiedni do leczenia lub zapobiegania gruźlicy |
| EP2471511A1 (en) | 2011-01-04 | 2012-07-04 | Archivel Farma, SL | Liposome formulation suitable for treating or preventing tuberculosis |
| WO2012138754A2 (en) * | 2011-04-04 | 2012-10-11 | Beth Israel Deaconess Medical Center, Inc. | Mycobacterial vaccine vectors and methods of using the same |
| WO2013033363A1 (en) * | 2011-08-30 | 2013-03-07 | The Uab Research Foundation | Mycobacterium tuberculosis porins and toxins and related methods |
| US10703784B2 (en) * | 2011-09-30 | 2020-07-07 | La Jolla Institute For Allergy And Immunology | Antigens and epitopes derived from Mycobacterium tuberculosis |
| US20140349320A1 (en) * | 2011-12-15 | 2014-11-27 | The Trustees Of The University Of Pennsylvania | Using Adaptive Immunity to Detect Drug Resistance |
| US10357555B2 (en) | 2012-07-10 | 2019-07-23 | Transgene Sa | Mycobacterial antigen vaccine |
| US10197560B2 (en) | 2013-06-27 | 2019-02-05 | The Brigham And Women's Hospital, Inc. | Methods and systems for determining M. tuberculosis infection |
| RU2695462C2 (ru) | 2014-01-09 | 2019-07-23 | Трансген Са | Гибридизация гетероолигомерных микобактериальных антигенов |
| GB201400819D0 (en) * | 2014-01-17 | 2014-03-05 | Sec Dep For Health The | Mycobacterial antigen composition |
| EP3180353B1 (en) * | 2014-08-15 | 2021-09-22 | Oxford Immunotec Limited | Mycobacterium tuberculosis proteins |
| CN108267588B (zh) * | 2016-12-30 | 2020-10-23 | 首都医科大学附属北京胸科医院 | 结核分枝杆菌蛋白在制备诊断结核潜伏感染者和/或活动性肺结核产品中的用途 |
| US12234464B2 (en) | 2018-11-09 | 2025-02-25 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| CN110129465B (zh) * | 2019-05-22 | 2023-08-22 | 杭州优思达生物技术股份有限公司 | 一种海分枝杆菌核酸的快速检测方法及其试剂盒 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9024320D0 (en) | 1990-11-08 | 1990-12-19 | Univ London | Treatment of uveitis |
| DE4221858A1 (de) | 1992-07-03 | 1994-01-05 | Becker Carl Chemie Gmbh | Addukte von 0,0-Dialkyldithiophosphorsäuren an ungesättigte Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schmiermitteladditive |
| US6583266B1 (en) * | 1993-08-19 | 2003-06-24 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to mycobacterium tuberculosis and leprae for diagnostics and therapeutics |
| US5783386A (en) | 1994-02-24 | 1998-07-21 | Agresearch, New Zealand Pastoral Agriculture Research Institute Ltd. | Mycobacteria virulence factors and a novel method for their identification |
| KR100445103B1 (ko) | 1994-12-09 | 2004-12-04 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의동정 |
| US6572865B1 (en) * | 1995-06-15 | 2003-06-03 | University Of Victoria Innovation And Development Corporation | Mycobacterium tuberculosis DNA sequences encoding immunostimulatory peptides and methods for using same |
| US5998194A (en) * | 1995-12-21 | 1999-12-07 | Abbott Laboratories | Polyketide-associated sugar biosynthesis genes |
| CA2197524A1 (en) * | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| EP0910403A1 (en) | 1996-03-27 | 1999-04-28 | The Johns-Hopkins University | Stationary phase, stress response sigma factor from mycobacterium tuberculosis, and regulation thereof |
| IL129389A0 (en) | 1996-10-11 | 2000-02-17 | Corixa Corp | Compounds and methods for diagnsosis of tuberculosis |
| US6555653B2 (en) * | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
| GB9711389D0 (en) | 1997-06-04 | 1997-07-30 | Univ Wales The | Bacterial pheromones and uses therefor |
| EP1003870A1 (en) | 1997-07-16 | 2000-05-31 | Institut Pasteur | A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same |
| AU9200398A (en) | 1997-08-22 | 1999-03-16 | Yale University | A process to study changes in gene expression in granulocytic cells |
| GB9723630D0 (en) | 1997-11-07 | 1998-01-07 | Stanford Rook Ltd | M.vaccae preparation and its use |
| US6183957B1 (en) | 1998-04-16 | 2001-02-06 | Institut Pasteur | Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria |
| EP1075485A4 (en) | 1998-05-05 | 2004-12-15 | Gene Logic Inc | METHOD FOR STUDYING MODIFICATIONS OF GENE EXPRESSION IN T CELLS |
| US6892139B2 (en) * | 1999-01-29 | 2005-05-10 | The Regents Of The University Of California | Determining the functions and interactions of proteins by comparative analysis |
| GB9904773D0 (en) | 1999-03-02 | 1999-04-28 | Microbiological Res Authority | Culture of mycobacteria |
| US6573361B1 (en) * | 1999-12-06 | 2003-06-03 | Monsanto Technology Llc | Antifungal proteins and methods for their use |
| US6613553B1 (en) * | 2000-02-04 | 2003-09-02 | St. Jude Children's Research Hospital | Enoyl reductases and methods of use thereof |
| WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| US7393539B2 (en) * | 2001-06-22 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed under low oxygen tension |
| EP2196473A1 (en) * | 2001-07-04 | 2010-06-16 | Health Protection Agency | Mycobacterial antigens expressed during latency |
| GB0125535D0 (en) | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
-
2002
- 2002-07-04 EP EP10150877A patent/EP2196473A1/en not_active Withdrawn
- 2002-07-04 CA CA2453173A patent/CA2453173C/en not_active Expired - Fee Related
- 2002-07-04 US US10/482,706 patent/US7393540B2/en not_active Expired - Fee Related
- 2002-07-04 AU AU2002314358A patent/AU2002314358C1/en not_active Ceased
- 2002-07-04 JP JP2003510686A patent/JP2005508613A/ja active Pending
- 2002-07-04 EP EP02740929A patent/EP1404706A2/en not_active Withdrawn
- 2002-07-04 WO PCT/GB2002/003052 patent/WO2003004520A2/en not_active Ceased
-
2008
- 2008-06-16 US US12/140,163 patent/US8003776B2/en not_active Expired - Fee Related
- 2008-11-05 AU AU2008243118A patent/AU2008243118A1/en not_active Abandoned
-
2011
- 2011-08-22 US US13/214,776 patent/US8399650B2/en not_active Expired - Fee Related
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