JP2005504523A5 - - Google Patents
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- Publication number
- JP2005504523A5 JP2005504523A5 JP2003507124A JP2003507124A JP2005504523A5 JP 2005504523 A5 JP2005504523 A5 JP 2005504523A5 JP 2003507124 A JP2003507124 A JP 2003507124A JP 2003507124 A JP2003507124 A JP 2003507124A JP 2005504523 A5 JP2005504523 A5 JP 2005504523A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- dissolved oxygen
- air saturation
- peptide
- continuous culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 35
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 29
- 229910052760 oxygen Inorganic materials 0.000 claims 29
- 239000001301 oxygen Substances 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 201000008827 tuberculosis Diseases 0.000 claims 19
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 15
- 239000002299 complementary DNA Substances 0.000 claims 14
- 230000002238 attenuated effect Effects 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 11
- 230000001105 regulatory effect Effects 0.000 claims 11
- 238000000034 method Methods 0.000 claims 8
- 108091026890 Coding region Proteins 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 5
- 230000000813 microbial effect Effects 0.000 claims 5
- 230000008488 polyadenylation Effects 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 239000013612 plasmid Substances 0.000 claims 4
- 206010062207 Mycobacterial infection Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000003929 Transaminases Human genes 0.000 claims 2
- 108090000340 Transaminases Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 108091011108 ATP binding proteins Proteins 0.000 claims 1
- 102000021527 ATP binding proteins Human genes 0.000 claims 1
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims 1
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims 1
- 101710126783 Acetyl-hydrolase Proteins 0.000 claims 1
- 101710146995 Acyl carrier protein Proteins 0.000 claims 1
- 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 claims 1
- 101000787278 Arabidopsis thaliana Valine-tRNA ligase, chloroplastic/mitochondrial 2 Proteins 0.000 claims 1
- 101000787296 Arabidopsis thaliana Valine-tRNA ligase, mitochondrial 1 Proteins 0.000 claims 1
- 102000018832 Cytochromes Human genes 0.000 claims 1
- 108010052832 Cytochromes Proteins 0.000 claims 1
- 101000787280 Dictyostelium discoideum Probable valine-tRNA ligase, mitochondrial Proteins 0.000 claims 1
- 108090000371 Esterases Proteins 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 108020004202 Guanylate Kinase Proteins 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 241000589343 Methylobacter luteus Species 0.000 claims 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 claims 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 claims 1
- 229930183781 Mycobactin Natural products 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102000055027 Protein Methyltransferases Human genes 0.000 claims 1
- 108700040121 Protein Methyltransferases Proteins 0.000 claims 1
- 108020001991 Protoporphyrinogen Oxidase Proteins 0.000 claims 1
- 102000005135 Protoporphyrinogen oxidase Human genes 0.000 claims 1
- 102000013009 Pyruvate Kinase Human genes 0.000 claims 1
- 108020005115 Pyruvate Kinase Proteins 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 102000013625 Valine-tRNA Ligase Human genes 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 108010006025 bovine growth hormone Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 102000006638 guanylate kinase Human genes 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- XZGYBQIQSLSHDH-COEJQBHMSA-N mycobactin Chemical compound C1CCCN(O)C(=O)C1NC(=O)C(C)C(CC)OC(=O)C(CCCCN(O)C(=O)\C=C/CCCCCCCCCCCCCCC)NC(=O)C(N=1)COC=1C1=C(C)C=CC=C1O XZGYBQIQSLSHDH-COEJQBHMSA-N 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- -1 sigma factor Proteins 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0115365A GB0115365D0 (en) | 2001-06-22 | 2001-06-22 | Mycobacterial antigens expressed under low oxygen tension |
| GB0121780A GB0121780D0 (en) | 2001-09-07 | 2001-09-07 | Mycobacterial antigens expressed under low oxygen tension |
| PCT/GB2002/002845 WO2003000721A2 (en) | 2001-06-22 | 2002-06-21 | Mycobacterial antigens expressed under low oxygen tension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504523A JP2005504523A (ja) | 2005-02-17 |
| JP2005504523A5 true JP2005504523A5 (enExample) | 2005-12-22 |
Family
ID=26246235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003507124A Pending JP2005504523A (ja) | 2001-06-22 | 2002-06-21 | 低酸素圧下で発現するマイコバクテリア抗原 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7393539B2 (enExample) |
| EP (1) | EP1401867A2 (enExample) |
| JP (1) | JP2005504523A (enExample) |
| AU (1) | AU2002317940B9 (enExample) |
| CA (1) | CA2451026C (enExample) |
| WO (1) | WO2003000721A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1350546A (zh) | 1998-11-04 | 2002-05-22 | Isis创新有限公司 | 结核诊断测验 |
| US7393539B2 (en) | 2001-06-22 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed under low oxygen tension |
| EP2196473A1 (en) | 2001-07-04 | 2010-06-16 | Health Protection Agency | Mycobacterial antigens expressed during latency |
| GB0125535D0 (en) * | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
| US7850970B2 (en) | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| CN102124029A (zh) * | 2008-05-26 | 2011-07-13 | 泰里安诊断有限公司 | 诊断由分枝杆菌引起的感染的方法和针对其的试剂 |
| US20100159485A1 (en) * | 2008-12-19 | 2010-06-24 | Centre For Dna Fingerprinting And Diagnostics | Detection of mycobacterium tuberculosis |
| WO2010096882A1 (en) * | 2009-02-26 | 2010-09-02 | Tyrian Diagnostics Limited | Method of diagnosis of infection by mycobacteria and reagents therefor |
| US8367055B2 (en) | 2009-05-14 | 2013-02-05 | Wisconsin Alumni Research Foundation | Immunogenic compositions against tuberculosis |
| GB201008512D0 (en) | 2010-05-21 | 2010-07-07 | Health Prot Agency | Mycobacterial antigen composition |
| BR112013026929A2 (pt) * | 2011-04-20 | 2016-12-27 | Mico Bio Inc | composição e método para intensificação de uma resposta imune |
| US9938353B2 (en) | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US10703784B2 (en) * | 2011-09-30 | 2020-07-07 | La Jolla Institute For Allergy And Immunology | Antigens and epitopes derived from Mycobacterium tuberculosis |
| US10478508B2 (en) | 2012-01-10 | 2019-11-19 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| WO2013170154A1 (en) * | 2012-05-10 | 2013-11-14 | Albert Einstein College Of Medicine Of Yeshiva University | Mycobacterium tuberculosis δesx-3 mutants |
| US10357555B2 (en) | 2012-07-10 | 2019-07-23 | Transgene Sa | Mycobacterial antigen vaccine |
| RU2695462C2 (ru) | 2014-01-09 | 2019-07-23 | Трансген Са | Гибридизация гетероолигомерных микобактериальных антигенов |
| CN106237317A (zh) * | 2015-06-15 | 2016-12-21 | 复旦大学 | 由结核分枝杆菌抗原组成的结核疫苗 |
| WO2019224673A1 (en) * | 2018-05-19 | 2019-11-28 | Jamia Hamdard University | Signature protein of mycobacterium tuberculosis and its methods of use |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9024320D0 (en) | 1990-11-08 | 1990-12-19 | Univ London | Treatment of uveitis |
| DE4221858A1 (de) | 1992-07-03 | 1994-01-05 | Becker Carl Chemie Gmbh | Addukte von 0,0-Dialkyldithiophosphorsäuren an ungesättigte Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schmiermitteladditive |
| US6583266B1 (en) * | 1993-08-19 | 2003-06-24 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to mycobacterium tuberculosis and leprae for diagnostics and therapeutics |
| US5783386A (en) * | 1994-02-24 | 1998-07-21 | Agresearch, New Zealand Pastoral Agriculture Research Institute Ltd. | Mycobacteria virulence factors and a novel method for their identification |
| KR100445103B1 (ko) | 1994-12-09 | 2004-12-04 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의동정 |
| US6572865B1 (en) * | 1995-06-15 | 2003-06-03 | University Of Victoria Innovation And Development Corporation | Mycobacterium tuberculosis DNA sequences encoding immunostimulatory peptides and methods for using same |
| US5998194A (en) * | 1995-12-21 | 1999-12-07 | Abbott Laboratories | Polyketide-associated sugar biosynthesis genes |
| CA2197524A1 (en) * | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| EP0910403A1 (en) | 1996-03-27 | 1999-04-28 | The Johns-Hopkins University | Stationary phase, stress response sigma factor from mycobacterium tuberculosis, and regulation thereof |
| IL129389A0 (en) | 1996-10-11 | 2000-02-17 | Corixa Corp | Compounds and methods for diagnsosis of tuberculosis |
| US6555653B2 (en) | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
| GB9711389D0 (en) | 1997-06-04 | 1997-07-30 | Univ Wales The | Bacterial pheromones and uses therefor |
| EP1003870A1 (en) | 1997-07-16 | 2000-05-31 | Institut Pasteur | A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same |
| AU9200398A (en) | 1997-08-22 | 1999-03-16 | Yale University | A process to study changes in gene expression in granulocytic cells |
| GB9723630D0 (en) | 1997-11-07 | 1998-01-07 | Stanford Rook Ltd | M.vaccae preparation and its use |
| US6183957B1 (en) * | 1998-04-16 | 2001-02-06 | Institut Pasteur | Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria |
| EP1075485A4 (en) | 1998-05-05 | 2004-12-15 | Gene Logic Inc | METHOD FOR STUDYING MODIFICATIONS OF GENE EXPRESSION IN T CELLS |
| US6892139B2 (en) * | 1999-01-29 | 2005-05-10 | The Regents Of The University Of California | Determining the functions and interactions of proteins by comparative analysis |
| GB9904773D0 (en) | 1999-03-02 | 1999-04-28 | Microbiological Res Authority | Culture of mycobacteria |
| US6573361B1 (en) * | 1999-12-06 | 2003-06-03 | Monsanto Technology Llc | Antifungal proteins and methods for their use |
| US6613553B1 (en) * | 2000-02-04 | 2003-09-02 | St. Jude Children's Research Hospital | Enoyl reductases and methods of use thereof |
| WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| US7393539B2 (en) * | 2001-06-22 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed under low oxygen tension |
| EP2196473A1 (en) * | 2001-07-04 | 2010-06-16 | Health Protection Agency | Mycobacterial antigens expressed during latency |
| GB0125535D0 (en) | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
-
2002
- 2002-06-21 US US10/481,265 patent/US7393539B2/en not_active Expired - Fee Related
- 2002-06-21 EP EP02747549A patent/EP1401867A2/en not_active Withdrawn
- 2002-06-21 WO PCT/GB2002/002845 patent/WO2003000721A2/en not_active Ceased
- 2002-06-21 JP JP2003507124A patent/JP2005504523A/ja active Pending
- 2002-06-21 AU AU2002317940A patent/AU2002317940B9/en not_active Ceased
- 2002-06-21 CA CA2451026A patent/CA2451026C/en not_active Expired - Fee Related
-
2008
- 2008-06-17 US US12/140,939 patent/US8017753B2/en not_active Expired - Fee Related
-
2011
- 2011-08-30 US US13/220,894 patent/US8404826B2/en not_active Expired - Fee Related
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