CA2451026C - Mycobacterial antigens expressed under low oxygen tension - Google Patents
Mycobacterial antigens expressed under low oxygen tension Download PDFInfo
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- CA2451026C CA2451026C CA2451026A CA2451026A CA2451026C CA 2451026 C CA2451026 C CA 2451026C CA 2451026 A CA2451026 A CA 2451026A CA 2451026 A CA2451026 A CA 2451026A CA 2451026 C CA2451026 C CA 2451026C
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- ala
- leu
- val
- gly
- arg
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- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 1
- 108010072644 valyl-alanyl-prolyl-glycine Proteins 0.000 description 1
- 108010009962 valyltyrosine Proteins 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 108010027345 wheylin-1 peptide Proteins 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0115365A GB0115365D0 (en) | 2001-06-22 | 2001-06-22 | Mycobacterial antigens expressed under low oxygen tension |
| GB0115365.9 | 2001-06-22 | ||
| GB0121780A GB0121780D0 (en) | 2001-09-07 | 2001-09-07 | Mycobacterial antigens expressed under low oxygen tension |
| GB0121780.1 | 2001-09-07 | ||
| PCT/GB2002/002845 WO2003000721A2 (en) | 2001-06-22 | 2002-06-21 | Mycobacterial antigens expressed under low oxygen tension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2451026A1 CA2451026A1 (en) | 2003-01-03 |
| CA2451026C true CA2451026C (en) | 2013-12-10 |
Family
ID=26246235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2451026A Expired - Fee Related CA2451026C (en) | 2001-06-22 | 2002-06-21 | Mycobacterial antigens expressed under low oxygen tension |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7393539B2 (enExample) |
| EP (1) | EP1401867A2 (enExample) |
| JP (1) | JP2005504523A (enExample) |
| AU (1) | AU2002317940B9 (enExample) |
| CA (1) | CA2451026C (enExample) |
| WO (1) | WO2003000721A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1350546A (zh) | 1998-11-04 | 2002-05-22 | Isis创新有限公司 | 结核诊断测验 |
| US7393539B2 (en) | 2001-06-22 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed under low oxygen tension |
| EP2196473A1 (en) | 2001-07-04 | 2010-06-16 | Health Protection Agency | Mycobacterial antigens expressed during latency |
| GB0125535D0 (en) * | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
| US7850970B2 (en) | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| CN102124029A (zh) * | 2008-05-26 | 2011-07-13 | 泰里安诊断有限公司 | 诊断由分枝杆菌引起的感染的方法和针对其的试剂 |
| US20100159485A1 (en) * | 2008-12-19 | 2010-06-24 | Centre For Dna Fingerprinting And Diagnostics | Detection of mycobacterium tuberculosis |
| WO2010096882A1 (en) * | 2009-02-26 | 2010-09-02 | Tyrian Diagnostics Limited | Method of diagnosis of infection by mycobacteria and reagents therefor |
| US8367055B2 (en) | 2009-05-14 | 2013-02-05 | Wisconsin Alumni Research Foundation | Immunogenic compositions against tuberculosis |
| GB201008512D0 (en) | 2010-05-21 | 2010-07-07 | Health Prot Agency | Mycobacterial antigen composition |
| BR112013026929A2 (pt) * | 2011-04-20 | 2016-12-27 | Mico Bio Inc | composição e método para intensificação de uma resposta imune |
| US9938353B2 (en) | 2011-06-24 | 2018-04-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US10703784B2 (en) * | 2011-09-30 | 2020-07-07 | La Jolla Institute For Allergy And Immunology | Antigens and epitopes derived from Mycobacterium tuberculosis |
| US10478508B2 (en) | 2012-01-10 | 2019-11-19 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| WO2013170154A1 (en) * | 2012-05-10 | 2013-11-14 | Albert Einstein College Of Medicine Of Yeshiva University | Mycobacterium tuberculosis δesx-3 mutants |
| US10357555B2 (en) | 2012-07-10 | 2019-07-23 | Transgene Sa | Mycobacterial antigen vaccine |
| RU2695462C2 (ru) | 2014-01-09 | 2019-07-23 | Трансген Са | Гибридизация гетероолигомерных микобактериальных антигенов |
| CN106237317A (zh) * | 2015-06-15 | 2016-12-21 | 复旦大学 | 由结核分枝杆菌抗原组成的结核疫苗 |
| WO2019224673A1 (en) * | 2018-05-19 | 2019-11-28 | Jamia Hamdard University | Signature protein of mycobacterium tuberculosis and its methods of use |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB9024320D0 (en) | 1990-11-08 | 1990-12-19 | Univ London | Treatment of uveitis |
| DE4221858A1 (de) | 1992-07-03 | 1994-01-05 | Becker Carl Chemie Gmbh | Addukte von 0,0-Dialkyldithiophosphorsäuren an ungesättigte Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schmiermitteladditive |
| US6583266B1 (en) * | 1993-08-19 | 2003-06-24 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to mycobacterium tuberculosis and leprae for diagnostics and therapeutics |
| US5783386A (en) * | 1994-02-24 | 1998-07-21 | Agresearch, New Zealand Pastoral Agriculture Research Institute Ltd. | Mycobacteria virulence factors and a novel method for their identification |
| KR100445103B1 (ko) | 1994-12-09 | 2004-12-04 | 임페리얼 컬리지 이노베이션스 리미티드 | 유전자의동정 |
| US6572865B1 (en) * | 1995-06-15 | 2003-06-03 | University Of Victoria Innovation And Development Corporation | Mycobacterium tuberculosis DNA sequences encoding immunostimulatory peptides and methods for using same |
| US5998194A (en) * | 1995-12-21 | 1999-12-07 | Abbott Laboratories | Polyketide-associated sugar biosynthesis genes |
| CA2197524A1 (en) * | 1996-02-22 | 1997-08-22 | Bradley Stuart Dehoff | Polyketide synthase genes |
| EP0910403A1 (en) | 1996-03-27 | 1999-04-28 | The Johns-Hopkins University | Stationary phase, stress response sigma factor from mycobacterium tuberculosis, and regulation thereof |
| IL129389A0 (en) | 1996-10-11 | 2000-02-17 | Corixa Corp | Compounds and methods for diagnsosis of tuberculosis |
| US6555653B2 (en) | 1997-05-20 | 2003-04-29 | Corixa Corporation | Compounds for diagnosis of tuberculosis and methods for their use |
| GB9711389D0 (en) | 1997-06-04 | 1997-07-30 | Univ Wales The | Bacterial pheromones and uses therefor |
| EP1003870A1 (en) | 1997-07-16 | 2000-05-31 | Institut Pasteur | A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as methods using the same |
| AU9200398A (en) | 1997-08-22 | 1999-03-16 | Yale University | A process to study changes in gene expression in granulocytic cells |
| GB9723630D0 (en) | 1997-11-07 | 1998-01-07 | Stanford Rook Ltd | M.vaccae preparation and its use |
| US6183957B1 (en) * | 1998-04-16 | 2001-02-06 | Institut Pasteur | Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria |
| EP1075485A4 (en) | 1998-05-05 | 2004-12-15 | Gene Logic Inc | METHOD FOR STUDYING MODIFICATIONS OF GENE EXPRESSION IN T CELLS |
| US6892139B2 (en) * | 1999-01-29 | 2005-05-10 | The Regents Of The University Of California | Determining the functions and interactions of proteins by comparative analysis |
| GB9904773D0 (en) | 1999-03-02 | 1999-04-28 | Microbiological Res Authority | Culture of mycobacteria |
| US6573361B1 (en) * | 1999-12-06 | 2003-06-03 | Monsanto Technology Llc | Antifungal proteins and methods for their use |
| US6613553B1 (en) * | 2000-02-04 | 2003-09-02 | St. Jude Children's Research Hospital | Enoyl reductases and methods of use thereof |
| WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| US7393539B2 (en) * | 2001-06-22 | 2008-07-01 | Health Protection Agency | Mycobacterial antigens expressed under low oxygen tension |
| EP2196473A1 (en) * | 2001-07-04 | 2010-06-16 | Health Protection Agency | Mycobacterial antigens expressed during latency |
| GB0125535D0 (en) | 2001-10-24 | 2001-12-12 | Microbiological Res Authority | Mycobacterial genes down-regulated during latency |
-
2002
- 2002-06-21 US US10/481,265 patent/US7393539B2/en not_active Expired - Fee Related
- 2002-06-21 EP EP02747549A patent/EP1401867A2/en not_active Withdrawn
- 2002-06-21 WO PCT/GB2002/002845 patent/WO2003000721A2/en not_active Ceased
- 2002-06-21 JP JP2003507124A patent/JP2005504523A/ja active Pending
- 2002-06-21 AU AU2002317940A patent/AU2002317940B9/en not_active Ceased
- 2002-06-21 CA CA2451026A patent/CA2451026C/en not_active Expired - Fee Related
-
2008
- 2008-06-17 US US12/140,939 patent/US8017753B2/en not_active Expired - Fee Related
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2011
- 2011-08-30 US US13/220,894 patent/US8404826B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7393539B2 (en) | 2008-07-01 |
| WO2003000721A2 (en) | 2003-01-03 |
| WO2003000721A3 (en) | 2003-06-26 |
| US8404826B2 (en) | 2013-03-26 |
| AU2002317940B9 (en) | 2008-06-05 |
| AU2002317940B2 (en) | 2007-12-20 |
| US20090054367A1 (en) | 2009-02-26 |
| US20120088297A1 (en) | 2012-04-12 |
| CA2451026A1 (en) | 2003-01-03 |
| US20040254349A1 (en) | 2004-12-16 |
| US8017753B2 (en) | 2011-09-13 |
| EP1401867A2 (en) | 2004-03-31 |
| JP2005504523A (ja) | 2005-02-17 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150622 |