JP2005508381A - 非置換の１−アミノ−アルキルシクロヘキサンｎｍｄａ、５ｈｔ３及び神経性ニコチンレセプターアンタゴニスト - Google Patents

非置換の１−アミノ−アルキルシクロヘキサンｎｍｄａ、５ｈｔ３及び神経性ニコチンレセプターアンタゴニスト Download PDF

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JP2005508381A
JP2005508381A JP2003542132A JP2003542132A JP2005508381A JP 2005508381 A JP2005508381 A JP 2005508381A JP 2003542132 A JP2003542132 A JP 2003542132A JP 2003542132 A JP2003542132 A JP 2003542132A JP 2005508381 A JP2005508381 A JP 2005508381A
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linear
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cyclohexa
diene
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JP2005508381A5 (https=
Inventor
パーソンズ・クリストファー・グラハム・ラファエル
ヘンリヒ・マルクス
ダニシュ・ヴォイチェク
カルヴィンシュ・イヴァース
カオス・ヴァレーヤンス
イルゲンソンス・アイガース
ゴルト・マルクス
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メルツ・ファルマ・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト・アウフ・アクティーン
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Publication of JP2005508381A publication Critical patent/JP2005508381A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
JP2003542132A 2001-11-07 2002-11-07 非置換の１−アミノ−アルキルシクロヘキサンｎｍｄａ、５ｈｔ３及び神経性ニコチンレセプターアンタゴニスト Pending JP2005508381A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35097401P 2001-11-07 2001-11-07
US33785801P 2001-11-08 2001-11-08
PCT/GB2002/005038 WO2003040084A1 (en) 2001-11-07 2002-11-07 Unsaturated 1-amino-alkylcyclohexane nmda, 5ht3 and neuronal nicotinic receptor antagonists

Publications (2)

Publication Number Publication Date
JP2005508381A true JP2005508381A (ja) 2005-03-31
JP2005508381A5 JP2005508381A5 (https=) 2008-05-08

Family

ID=26990903

Family Applications (1)

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JP2003542132A Pending JP2005508381A (ja) 2001-11-07 2002-11-07 非置換の１−アミノ−アルキルシクロヘキサンｎｍｄａ、５ｈｔ３及び神経性ニコチンレセプターアンタゴニスト

Country Status (16)

Country Link
US (1) US6828462B2 (https=)
EP (1) EP1442008A1 (https=)
JP (1) JP2005508381A (https=)
KR (1) KR100655975B1 (https=)
CN (1) CN100390131C (https=)
AU (1) AU2002337389B2 (https=)
CA (1) CA2465738C (https=)
CO (1) CO5570696A2 (https=)
EA (1) EA010177B1 (https=)
GE (1) GEP20053714B (https=)
HU (1) HUP0402028A3 (https=)
IL (1) IL161801A0 (https=)
MX (1) MXPA04004412A (https=)
NO (1) NO20042338L (https=)
PL (1) PL370245A1 (https=)
WO (1) WO2003040084A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW593223B (en) * 2000-06-20 2004-06-21 Merz Pharma Gmbh & Co Kgaa 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists
AU2004258751C1 (en) * 2003-07-28 2008-07-17 Merz Pharma Gmbh & Co. Kgaa The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity
AR046314A1 (es) * 2003-11-05 2005-11-30 Merz Pharma Gmbh & Co Kgaa Composiciones que comprenden ciclohexilaminas y aminoadamantanos
TW200531680A (en) * 2004-03-03 2005-10-01 Merz Pharma Gmbh & Co Kgaa Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease
ES2483126T3 (es) * 2004-06-17 2014-08-05 Merz Pharma Gmbh & Co. Kgaa Formulaciones de formas de dosificación de neramexano
US7427601B2 (en) * 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
WO2008103421A1 (en) * 2007-02-21 2008-08-28 Ssv Therapeutics, Inc. Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids
EP2111858A1 (en) 2008-04-25 2009-10-28 EPFL Ecole Polytechnique Fédérale de Lausanne Novel treatment for alzheimer's disease
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
ME01898B (me) 2008-08-12 2014-12-20 Zinfandel Pharmaceuticals Inc Metoda za identifikaciju faktora rizika od alchajmerove bolesti
AU2012205798B2 (en) 2011-01-10 2016-02-25 Takeda Pharmaceutical Company Limited Methods and drug products for treating Alzheimer's disease
WO2014150318A1 (en) * 2013-03-15 2014-09-25 Mitochondrial Concepts Llc Therapeutic agent for enhancing mitochondrial function
EP3568388A4 (en) * 2017-01-10 2020-10-14 Owen-Barry Pharmaceuticals Inc. ANTICONVULSIVING COMPOUNDS
AU2024287244B1 (en) * 2024-12-28 2025-08-21 Lai, Meng Hong MR A device for relieving constipation and its preparation method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267366A (en) * 1977-12-14 1981-05-12 Scm Corporation Cyclic terpenoid amines, their preparation and uses
US6071966A (en) 1997-06-30 2000-06-06 Merz + Co. Gmbh & Co. 1-amino-alkylcyclohexane NMDA receptor antagonists
UA61962C2 (uk) * 1997-06-30 2003-12-15 Мерц Фарма Гмбх Унд Ко. Кгаа Сполука 1-аміноалкілциклогексану, фармацевтична композиція на її основі та спосіб лікування

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CA2465738C (en) 2009-01-20
CO5570696A2 (es) 2005-10-31
NO20042338L (no) 2004-07-21
WO2003040084A1 (en) 2003-05-15
CN1602292A (zh) 2005-03-30
HUP0402028A2 (hu) 2005-01-28
EA200400637A1 (ru) 2004-10-28
AU2002337389B2 (en) 2005-12-08
CA2465738A1 (en) 2003-05-15
CN100390131C (zh) 2008-05-28
EP1442008A1 (en) 2004-08-04
HUP0402028A3 (en) 2008-03-28
PL370245A1 (en) 2005-05-16
KR20050044354A (ko) 2005-05-12
HK1075037A1 (zh) 2005-12-02
EA010177B1 (ru) 2008-06-30
GEP20053714B (en) 2005-12-26
KR100655975B1 (ko) 2006-12-08
US6828462B2 (en) 2004-12-07
MXPA04004412A (es) 2005-05-16
US20030166634A1 (en) 2003-09-04
IL161801A0 (en) 2005-11-20

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