JP2005508348A5 - - Google Patents

Info

Publication number

JP2005508348A5

JP2005508348A5 JP2003533908A JP2003533908A JP2005508348A5 JP 2005508348 A5 JP2005508348 A5 JP 2005508348A5 JP 2003533908 A JP2003533908 A JP 2003533908A JP 2003533908 A JP2003533908 A JP 2003533908A JP 2005508348 A5 JP2005508348 A5 JP 2005508348A5

Authority

JP

Japan

Prior art keywords

composition

saccharide

mouth

dissolving

additive

Prior art date

2002-10-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 18
• 150000001720 carbohydrates Chemical class 0.000 claims 12
• 210000000214 mouth Anatomy 0.000 claims 12
• 239000000654 additive Substances 0.000 claims 11
• 230000000996 additive effect Effects 0.000 claims 11
• 238000000034 method Methods 0.000 claims 7
• LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims 6
• 229960002004 valdecoxib Drugs 0.000 claims 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
• 230000001747 exhibiting effect Effects 0.000 claims 4
• 238000001694 spray drying Methods 0.000 claims 4
• 238000009472 formulation Methods 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000007921 spray Substances 0.000 claims 2
• 239000000080 wetting agent Substances 0.000 claims 2
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 1
• 238000010438 heat treatment Methods 0.000 claims 1
• 239000008101 lactose Substances 0.000 claims 1
• 239000000845 maltitol Substances 0.000 claims 1
• VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
• 235000010449 maltitol Nutrition 0.000 claims 1
• 229940035436 maltitol Drugs 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 239000000600 sorbitol Substances 0.000 claims 1
• 239000007916 tablet composition Substances 0.000 claims 1