JP2005508337A - 化合物 - Google Patents
化合物 Download PDFInfo
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- JP2005508337A JP2005508337A JP2003530699A JP2003530699A JP2005508337A JP 2005508337 A JP2005508337 A JP 2005508337A JP 2003530699 A JP2003530699 A JP 2003530699A JP 2003530699 A JP2003530699 A JP 2003530699A JP 2005508337 A JP2005508337 A JP 2005508337A
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- Prior art keywords
- compound
- physiologically functional
- disease
- alkyl
- compounds
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 125
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- -1 3-bromo-4-hydroxy-5- (2′methoxyphenyl) -benzylidene Chemical group 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 34
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- 239000001257 hydrogen Substances 0.000 claims description 14
- 229910052736 halogen Chemical group 0.000 claims description 11
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- 241000124008 Mammalia Species 0.000 claims description 9
- 125000001246 bromo group Chemical group Br* 0.000 claims description 7
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- 239000003085 diluting agent Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
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- MQUFHXHELBTYIX-WQLSENKSSA-N (3z)-3-(1h-indol-3-ylmethylidene)-1h-pyrrolo[3,2-b]pyridin-2-one Chemical compound C1=CC=C2C(/C=C3/C4=NC=CC=C4NC3=O)=CNC2=C1 MQUFHXHELBTYIX-WQLSENKSSA-N 0.000 claims 1
- NXNQLECPAXXYTR-LCYFTJDESA-N (3z)-3-[(1-methylindol-3-yl)methylidene]-1h-pyrrolo[3,2-b]pyridin-2-one Chemical compound C12=CC=CC=C2N(C)C=C1\C=C/1C2=NC=CC=C2NC\1=O NXNQLECPAXXYTR-LCYFTJDESA-N 0.000 claims 1
- UAFSJUAEOZQXJJ-UHFFFAOYSA-N 3-(1h-indol-3-ylmethylidene)-1h-pyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CC=C2C(C=C3C4=CC=CN=C4NC3=O)=CNC2=C1 UAFSJUAEOZQXJJ-UHFFFAOYSA-N 0.000 claims 1
- RJBBKRZRJMHITR-UHFFFAOYSA-N 3-[(1-methylindol-3-yl)methylidene]-1h-pyrrolo[2,3-b]pyridin-2-one Chemical compound C12=CC=CC=C2N(C)C=C1C=C1C2=CC=CN=C2NC1=O RJBBKRZRJMHITR-UHFFFAOYSA-N 0.000 claims 1
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- 125000003118 aryl group Chemical group 0.000 description 9
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- 125000001072 heteroaryl group Chemical group 0.000 description 6
- 125000000623 heterocyclic group Chemical group 0.000 description 6
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 5
- IHRRHTILSRVFPW-UHFFFAOYSA-N 1,3-dihydropyrrolo[3,2-b]pyridin-2-one Chemical group C1=CC=C2NC(=O)CC2=N1 IHRRHTILSRVFPW-UHFFFAOYSA-N 0.000 description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Diabetes (AREA)
- Immunology (AREA)
- Neurology (AREA)
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- Rheumatology (AREA)
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- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32601201P | 2001-09-27 | 2001-09-27 | |
| PCT/US2002/030150 WO2003027111A1 (en) | 2001-09-27 | 2002-09-24 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508337A true JP2005508337A (ja) | 2005-03-31 |
| JP2005508337A5 JP2005508337A5 (enExample) | 2005-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530699A Pending JP2005508337A (ja) | 2001-09-27 | 2002-09-24 | 化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7015231B2 (enExample) |
| EP (1) | EP1430053B1 (enExample) |
| JP (1) | JP2005508337A (enExample) |
| AT (1) | ATE343575T1 (enExample) |
| DE (1) | DE60215682T2 (enExample) |
| ES (1) | ES2275021T3 (enExample) |
| WO (1) | WO2003027111A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2002020479A1 (en) | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
| EP1317446A1 (en) | 2000-09-01 | 2003-06-11 | Glaxo Group Limited | Oxindole derivatives |
| JP2005508337A (ja) * | 2001-09-27 | 2005-03-31 | スミスクライン ビーチャム コーポレーション | 化合物 |
| CA2595834C (en) | 2005-02-04 | 2013-04-30 | Astrazeneca Ab | Pyrazolylaminopyridine derivatives useful as kinase inhibitors |
| WO2006087530A1 (en) | 2005-02-16 | 2006-08-24 | Astrazeneca Ab | Chemical compounds |
| ES2347172T3 (es) * | 2005-02-16 | 2010-10-26 | Astrazeneca Ab | Compuestos quimicos. |
| EP2388259A1 (en) | 2005-10-28 | 2011-11-23 | AstraZeneca AB | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| US7514435B2 (en) | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| CN101426774B (zh) | 2006-04-19 | 2012-04-25 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| WO2009054468A1 (ja) | 2007-10-24 | 2009-04-30 | Astellas Pharma Inc. | アゾールカルボキサミド化合物又はその塩 |
| US8426673B2 (en) | 2008-01-11 | 2013-04-23 | Astellas Pharma, Inc. | Pathological animal model for pelvic pain syndrome |
| EP2376495A4 (en) | 2008-12-08 | 2012-10-31 | Vm Pharma Llc | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS |
| AU2011240367B2 (en) * | 2010-04-15 | 2015-07-16 | Merck Patent Gmbh | Process for the preparation of hydroquinones |
| US8999992B2 (en) | 2013-03-15 | 2015-04-07 | Vm Pharma Llc | Crystalline forms of tryosine kinase inhibitors and their salts |
| CN103804273B (zh) * | 2014-01-27 | 2016-06-15 | 贵州大学 | 氧化吲哚与茚三酮双季碳拼接衍生物及其制备方法 |
| US10231965B2 (en) | 2014-02-20 | 2019-03-19 | Ignyta, Inc. | Molecules for administration to ROS1 mutant cancer cells |
| US10301271B2 (en) | 2014-09-17 | 2019-05-28 | Purdue Pharma L.P. | Crystalline forms of tyrosine kinase inhibitors and their salts |
| CA2969540C (en) | 2014-12-02 | 2023-03-21 | Ignyta, Inc. | Combinations for the treatment of neuroblastoma |
| WO2017106492A1 (en) | 2015-12-18 | 2017-06-22 | Ignyta, Inc. | Combinations for the treatment of cancer |
| KR102718538B1 (ko) | 2017-07-19 | 2024-10-21 | 이그니타, 인코포레이티드 | 엔트렉티닙을 포함하는 약학적 조성물 |
| CN111225662B (zh) | 2017-10-17 | 2022-11-22 | 伊尼塔公司 | 药物组合物和剂型 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (5)
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| GB9423997D0 (en) * | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| AU5468499A (en) * | 1998-08-04 | 2000-02-28 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
| JP2005508337A (ja) * | 2001-09-27 | 2005-03-31 | スミスクライン ビーチャム コーポレーション | 化合物 |
-
2002
- 2002-09-24 JP JP2003530699A patent/JP2005508337A/ja active Pending
- 2002-09-24 ES ES02799606T patent/ES2275021T3/es not_active Expired - Lifetime
- 2002-09-24 US US10/490,831 patent/US7015231B2/en not_active Expired - Fee Related
- 2002-09-24 EP EP02799606A patent/EP1430053B1/en not_active Expired - Lifetime
- 2002-09-24 DE DE60215682T patent/DE60215682T2/de not_active Expired - Fee Related
- 2002-09-24 AT AT02799606T patent/ATE343575T1/de not_active IP Right Cessation
- 2002-09-24 WO PCT/US2002/030150 patent/WO2003027111A1/en not_active Ceased
-
2006
- 2006-01-20 US US11/336,010 patent/US20060128745A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040198766A1 (en) | 2004-10-07 |
| EP1430053A1 (en) | 2004-06-23 |
| US7015231B2 (en) | 2006-03-21 |
| US20060128745A1 (en) | 2006-06-15 |
| WO2003027111A1 (en) | 2003-04-03 |
| DE60215682T2 (de) | 2007-09-06 |
| ATE343575T1 (de) | 2006-11-15 |
| EP1430053B1 (en) | 2006-10-25 |
| ES2275021T3 (es) | 2007-06-01 |
| DE60215682D1 (de) | 2006-12-07 |
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