DE60215682T2 - AZAOXOINDOL DERIVATE ALS Trk PROTEIN KINASE HEMMSTOFFE ZUR BEHANDLUNG VON KREBS UND CHRONISCHEM SCHMERZ - Google Patents
AZAOXOINDOL DERIVATE ALS Trk PROTEIN KINASE HEMMSTOFFE ZUR BEHANDLUNG VON KREBS UND CHRONISCHEM SCHMERZ Download PDFInfo
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- DE60215682T2 DE60215682T2 DE60215682T DE60215682T DE60215682T2 DE 60215682 T2 DE60215682 T2 DE 60215682T2 DE 60215682 T DE60215682 T DE 60215682T DE 60215682 T DE60215682 T DE 60215682T DE 60215682 T2 DE60215682 T2 DE 60215682T2
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32601201P | 2001-09-27 | 2001-09-27 | |
| US326012P | 2001-09-27 | ||
| PCT/US2002/030150 WO2003027111A1 (en) | 2001-09-27 | 2002-09-24 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60215682D1 DE60215682D1 (de) | 2006-12-07 |
| DE60215682T2 true DE60215682T2 (de) | 2007-09-06 |
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| DE60215682T Expired - Fee Related DE60215682T2 (de) | 2001-09-27 | 2002-09-24 | AZAOXOINDOL DERIVATE ALS Trk PROTEIN KINASE HEMMSTOFFE ZUR BEHANDLUNG VON KREBS UND CHRONISCHEM SCHMERZ |
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|---|---|
| US (2) | US7015231B2 (enExample) |
| EP (1) | EP1430053B1 (enExample) |
| JP (1) | JP2005508337A (enExample) |
| AT (1) | ATE343575T1 (enExample) |
| DE (1) | DE60215682T2 (enExample) |
| ES (1) | ES2275021T3 (enExample) |
| WO (1) | WO2003027111A1 (enExample) |
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| WO2002020479A1 (en) | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
| EP1317446A1 (en) | 2000-09-01 | 2003-06-11 | Glaxo Group Limited | Oxindole derivatives |
| JP2005508337A (ja) * | 2001-09-27 | 2005-03-31 | スミスクライン ビーチャム コーポレーション | 化合物 |
| CA2595834C (en) | 2005-02-04 | 2013-04-30 | Astrazeneca Ab | Pyrazolylaminopyridine derivatives useful as kinase inhibitors |
| WO2006087530A1 (en) | 2005-02-16 | 2006-08-24 | Astrazeneca Ab | Chemical compounds |
| ES2347172T3 (es) * | 2005-02-16 | 2010-10-26 | Astrazeneca Ab | Compuestos quimicos. |
| EP2388259A1 (en) | 2005-10-28 | 2011-11-23 | AstraZeneca AB | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| US7514435B2 (en) | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| CN101426774B (zh) | 2006-04-19 | 2012-04-25 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| WO2009054468A1 (ja) | 2007-10-24 | 2009-04-30 | Astellas Pharma Inc. | アゾールカルボキサミド化合物又はその塩 |
| US8426673B2 (en) | 2008-01-11 | 2013-04-23 | Astellas Pharma, Inc. | Pathological animal model for pelvic pain syndrome |
| EP2376495A4 (en) | 2008-12-08 | 2012-10-31 | Vm Pharma Llc | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS |
| AU2011240367B2 (en) * | 2010-04-15 | 2015-07-16 | Merck Patent Gmbh | Process for the preparation of hydroquinones |
| US8999992B2 (en) | 2013-03-15 | 2015-04-07 | Vm Pharma Llc | Crystalline forms of tryosine kinase inhibitors and their salts |
| CN103804273B (zh) * | 2014-01-27 | 2016-06-15 | 贵州大学 | 氧化吲哚与茚三酮双季碳拼接衍生物及其制备方法 |
| US10231965B2 (en) | 2014-02-20 | 2019-03-19 | Ignyta, Inc. | Molecules for administration to ROS1 mutant cancer cells |
| US10301271B2 (en) | 2014-09-17 | 2019-05-28 | Purdue Pharma L.P. | Crystalline forms of tyrosine kinase inhibitors and their salts |
| CA2969540C (en) | 2014-12-02 | 2023-03-21 | Ignyta, Inc. | Combinations for the treatment of neuroblastoma |
| WO2017106492A1 (en) | 2015-12-18 | 2017-06-22 | Ignyta, Inc. | Combinations for the treatment of cancer |
| KR102718538B1 (ko) | 2017-07-19 | 2024-10-21 | 이그니타, 인코포레이티드 | 엔트렉티닙을 포함하는 약학적 조성물 |
| CN111225662B (zh) | 2017-10-17 | 2022-11-22 | 伊尼塔公司 | 药物组合物和剂型 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9423997D0 (en) * | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| AU5468499A (en) * | 1998-08-04 | 2000-02-28 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
| JP2005508337A (ja) * | 2001-09-27 | 2005-03-31 | スミスクライン ビーチャム コーポレーション | 化合物 |
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2002
- 2002-09-24 JP JP2003530699A patent/JP2005508337A/ja active Pending
- 2002-09-24 ES ES02799606T patent/ES2275021T3/es not_active Expired - Lifetime
- 2002-09-24 US US10/490,831 patent/US7015231B2/en not_active Expired - Fee Related
- 2002-09-24 EP EP02799606A patent/EP1430053B1/en not_active Expired - Lifetime
- 2002-09-24 DE DE60215682T patent/DE60215682T2/de not_active Expired - Fee Related
- 2002-09-24 AT AT02799606T patent/ATE343575T1/de not_active IP Right Cessation
- 2002-09-24 WO PCT/US2002/030150 patent/WO2003027111A1/en not_active Ceased
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2006
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| US20040198766A1 (en) | 2004-10-07 |
| EP1430053A1 (en) | 2004-06-23 |
| US7015231B2 (en) | 2006-03-21 |
| US20060128745A1 (en) | 2006-06-15 |
| WO2003027111A1 (en) | 2003-04-03 |
| JP2005508337A (ja) | 2005-03-31 |
| ATE343575T1 (de) | 2006-11-15 |
| EP1430053B1 (en) | 2006-10-25 |
| ES2275021T3 (es) | 2007-06-01 |
| DE60215682D1 (de) | 2006-12-07 |
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