JP2005508306A5 - - Google Patents
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- Publication number
- JP2005508306A5 JP2005508306A5 JP2003515539A JP2003515539A JP2005508306A5 JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5 JP 2003515539 A JP2003515539 A JP 2003515539A JP 2003515539 A JP2003515539 A JP 2003515539A JP 2005508306 A5 JP2005508306 A5 JP 2005508306A5
- Authority
- JP
- Japan
- Prior art keywords
- embryo
- mammal
- adult
- immature body
- immature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 241000124008 Mammalia Species 0.000 claims 2
- 210000001161 mammalian embryo Anatomy 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30741101P | 2001-07-23 | 2001-07-23 | |
| US36066402P | 2002-02-27 | 2002-02-27 | |
| PCT/US2002/022869 WO2003010180A1 (en) | 2001-07-23 | 2002-07-19 | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010249697A Division JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Division JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508306A JP2005508306A (ja) | 2005-03-31 |
| JP2005508306A5 true JP2005508306A5 (OSRAM) | 2006-01-05 |
Family
ID=26975733
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515539A Withdrawn JP2005508306A (ja) | 2001-07-23 | 2002-07-19 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2010249697A Expired - Lifetime JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Pending JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2016159918A Expired - Lifetime JP6247355B2 (ja) | 2001-07-23 | 2016-08-17 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010249697A Expired - Lifetime JP6055164B2 (ja) | 2001-07-23 | 2010-11-08 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2014187281A Pending JP2015044809A (ja) | 2001-07-23 | 2014-09-16 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
| JP2016159918A Expired - Lifetime JP6247355B2 (ja) | 2001-07-23 | 2016-08-17 | 哺乳類における遺伝子発現のRNAiによる阻害に関する方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20030153519A1 (OSRAM) |
| EP (2) | EP1409506B1 (OSRAM) |
| JP (4) | JP2005508306A (OSRAM) |
| AT (1) | ATE556720T1 (OSRAM) |
| CA (2) | CA2936534C (OSRAM) |
| DK (2) | DK1409506T3 (OSRAM) |
| ES (2) | ES2546829T3 (OSRAM) |
| PT (1) | PT2280070E (OSRAM) |
| WO (1) | WO2003010180A1 (OSRAM) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040138168A1 (en) * | 1999-04-21 | 2004-07-15 | Wyeth | Methods and compositions for inhibiting the function of polynucleotide sequences |
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| JP2003526367A (ja) | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Rna干渉の方法とrna干渉組成物 |
| US10590418B2 (en) * | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| CA2936534C (en) | 2001-07-23 | 2021-01-26 | The Board Of Trustees Of Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
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| US7148342B2 (en) * | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
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| US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
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| CN1780912B (zh) * | 2003-02-28 | 2011-06-15 | 肿瘤疗法科学股份有限公司 | 抑制细胞生长的组合物和方法 |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| NZ574973A (en) * | 2003-06-06 | 2010-10-29 | Senesco Technologies Inc | Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNAs as anti-inflammatory therapeutics |
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| US20050233994A1 (en) * | 2004-04-16 | 2005-10-20 | Ajamete Kaykas | Methods and vectors for expressing siRNA |
| WO2005118640A2 (en) | 2004-04-20 | 2005-12-15 | University Of Utah Research Foundation | A h+-gated ion channel |
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| WO2006060743A2 (en) * | 2004-12-02 | 2006-06-08 | University Of Massachusetts | Glucose-transport related genes, polypeptides, and methods of use thereof |
| US20060142228A1 (en) * | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
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| EP1714970A1 (en) * | 2005-04-22 | 2006-10-25 | Universität des Saarlandes | Use of inhibitors of RNAse A-family enzymes for stabilizing oligonucleotides having RNA interfering activity |
| TW200741009A (en) | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
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| US7723314B1 (en) | 2005-10-28 | 2010-05-25 | Transderm, Inc. | Methods and compositions for treating pachyonychia congenita |
| JPWO2007080902A1 (ja) | 2006-01-11 | 2009-06-11 | 協和発酵キリン株式会社 | 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤 |
| WO2008016391A2 (en) * | 2006-01-31 | 2008-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Self-complementary parvoviral vectors, and methods for making and using the same |
| EP1991008A4 (en) * | 2006-02-27 | 2012-04-18 | Nikon Corp | IMAGE PROCESSING DEVICE FOR CORRECTING MASSIVE IMAGE PERCEPTION, IMAGE PROCESSING PROGRAM AND METHOD, AND ELECTRONIC CAMERA |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| EP2035439A4 (en) | 2006-06-05 | 2010-01-13 | Cancer Care Ontario | ASSESSMENT OF THE RISK OF COLORECTAL CANCER |
| EP2029746B1 (en) * | 2006-06-12 | 2012-07-04 | Exegenics, Inc., D/b/a Opko Health, Inc. | Compositions and methods for sirna inhibition of angiogenesis |
| US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| CA2679954A1 (en) | 2007-03-05 | 2008-09-12 | Cancer Care Ontario | Assessment of risk for colorectal cancer |
| TW200909587A (en) | 2007-06-14 | 2009-03-01 | Oncotherapy Science Inc | Methods of identifying agents that modulate methylation of VEGFR1 by SMYD3 |
| WO2009005813A1 (en) * | 2007-07-02 | 2009-01-08 | Wyeth | Modulators of axl for use in treating bone disorders |
| WO2010008562A2 (en) * | 2008-07-16 | 2010-01-21 | Recombinetics | Methods and materials for producing transgenic animals |
| CN105030809A (zh) * | 2008-08-01 | 2015-11-11 | 协和发酵麒麟株式会社 | 抑制靶基因表达的组合物 |
| SG171952A1 (en) | 2008-12-04 | 2011-07-28 | Opko Ophthalmics Llc | Compositions and methods for selective inhibition of pro-angiogenic vegf isoforms |
| CA2764158A1 (en) | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| US8871730B2 (en) | 2009-07-13 | 2014-10-28 | Somagenics Inc. | Chemical modification of short small hairpin RNAs for inhibition of gene expression |
| JP5952197B2 (ja) | 2011-01-19 | 2016-07-13 | 協和発酵キリン株式会社 | 標的遺伝子の発現を抑制する組成物 |
| JP6347743B2 (ja) | 2011-05-05 | 2018-06-27 | マティナス バイオファーマ ナノテクノロジーズ,インコーポレーテッド | コクリエート組成物およびその製造および使用方法 |
| WO2014013995A1 (ja) | 2012-07-16 | 2014-01-23 | 協和発酵キリン株式会社 | KRAS遺伝子発現抑制RNAi医薬組成物 |
| AU2013308519A1 (en) | 2012-08-31 | 2015-04-09 | The General Hospital Corporation | Biotin complexes for treatment and diagnosis of Alzheimer's disease |
| CN104342453A (zh) | 2013-08-06 | 2015-02-11 | 深圳先进技术研究院 | 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用 |
| US9545417B2 (en) | 2014-05-01 | 2017-01-17 | The Johns Hopkins University | Methods of inhibiting cancer stem cells with HMGA1 inhibitors |
| CN106794194A (zh) * | 2014-06-30 | 2017-05-31 | 中央研究院 | 用于癌症治疗的介白素‑17受体b(il‑17rb)及其配体il‑17b之拮抗剂 |
| US20170216363A1 (en) | 2014-08-07 | 2017-08-03 | The Johns Hopkins University | Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases |
| WO2016025629A1 (en) | 2014-08-12 | 2016-02-18 | The Regents Of The University Of California | Molecular composition for enhancing and rejuvenating maintenance and repair of mammalian tissues |
| US11219670B2 (en) | 2014-09-05 | 2022-01-11 | The Johns Hopkins University | Targeting CAPN9/CAPNS2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies |
| AU2016265948B2 (en) | 2015-05-18 | 2018-12-06 | Alkahest, Inc. | Methods and compositions for treating aging-associated impairments |
| MX2018002090A (es) | 2015-08-24 | 2018-09-12 | Halo Bio Rnai Therapeutics Inc | Nanoparticulas de polinucleótido para modulación de expresión génica y sus usos. |
| AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| WO2018064119A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| EP4225904A4 (en) | 2020-10-09 | 2025-10-08 | Univ Massachusetts | TARGETING NRIP1 TO ALLEVIATE METABOLIC DISEASE |
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| DE69034078T2 (de) | 1989-03-21 | 2004-04-01 | Vical, Inc., San Diego | Expression von exogenen Polynukleotidsequenzen in Wirbeltieren |
| US5610050A (en) * | 1990-04-20 | 1997-03-11 | The General Hospital Corporation | Methods of preventing viral replication |
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| ES2040615B1 (es) * | 1991-05-27 | 1994-05-16 | Nebrda Fernando Javi Bartolome | Procedimiento para el aislamiento y clonaje de cdnas derivados del virus c de la hepatitis. |
| US6030954A (en) * | 1991-09-05 | 2000-02-29 | University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
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| AU6230594A (en) * | 1993-02-01 | 1994-08-29 | University Of Iowa Research Foundation, The | Quartenary amine surfactants and methods of using same in isolation of rna |
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| ES2606290T3 (es) | 2001-07-12 | 2017-03-23 | University Of Massachusetts | Producción in vivo de ARN de interferencia pequeños que median el silenciamiento génico |
| CA2936534C (en) | 2001-07-23 | 2021-01-26 | The Board Of Trustees Of Leland Stanford Junior University | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
| JP2005517427A (ja) | 2002-02-20 | 2005-06-16 | サーナ・セラピューティクス・インコーポレイテッド | 短干渉核酸(siNA)を用いるC型肝炎ウイルス(HCV)遺伝子発現のRNA干渉媒介性阻害 |
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2002
- 2002-07-19 CA CA2936534A patent/CA2936534C/en not_active Expired - Lifetime
- 2002-07-19 JP JP2003515539A patent/JP2005508306A/ja not_active Withdrawn
- 2002-07-19 DK DK02761123.5T patent/DK1409506T3/da active
- 2002-07-19 DK DK10178509.5T patent/DK2280070T3/en active
- 2002-07-19 PT PT101785095T patent/PT2280070E/pt unknown
- 2002-07-19 CA CA2454183A patent/CA2454183C/en not_active Expired - Lifetime
- 2002-07-19 ES ES10178509.5T patent/ES2546829T3/es not_active Expired - Lifetime
- 2002-07-19 WO PCT/US2002/022869 patent/WO2003010180A1/en not_active Ceased
- 2002-07-19 EP EP02761123A patent/EP1409506B1/en not_active Expired - Lifetime
- 2002-07-19 EP EP10178509.5A patent/EP2280070B1/en not_active Expired - Lifetime
- 2002-07-19 US US10/200,002 patent/US20030153519A1/en not_active Abandoned
- 2002-07-19 ES ES02761123T patent/ES2386775T3/es not_active Expired - Lifetime
- 2002-07-19 AT AT02761123T patent/ATE556720T1/de active
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2010
- 2010-11-08 JP JP2010249697A patent/JP6055164B2/ja not_active Expired - Lifetime
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2013
- 2013-07-12 US US13/941,262 patent/US10517887B2/en not_active Expired - Fee Related
-
2014
- 2014-09-16 JP JP2014187281A patent/JP2015044809A/ja active Pending
-
2016
- 2016-08-17 JP JP2016159918A patent/JP6247355B2/ja not_active Expired - Lifetime
-
2019
- 2019-12-20 US US16/723,744 patent/US20200246370A1/en not_active Abandoned
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