JP2005507635A5 - - Google Patents
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- Publication number
- JP2005507635A5 JP2005507635A5 JP2002564963A JP2002564963A JP2005507635A5 JP 2005507635 A5 JP2005507635 A5 JP 2005507635A5 JP 2002564963 A JP2002564963 A JP 2002564963A JP 2002564963 A JP2002564963 A JP 2002564963A JP 2005507635 A5 JP2005507635 A5 JP 2005507635A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- human
- antigen
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 23
- 108091007433 antigens Proteins 0.000 claims 23
- 102000036639 antigens Human genes 0.000 claims 23
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 13
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 13
- 125000000539 amino acid group Chemical group 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 108700019146 Transgenes Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 102000001301 EGF receptor Human genes 0.000 claims 7
- 108060006698 EGF receptor Proteins 0.000 claims 7
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 6
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 6
- 230000009261 transgenic effect Effects 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims 5
- 210000004408 hybridoma Anatomy 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 4
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 4
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 4
- 102000009109 Fc receptors Human genes 0.000 claims 4
- 108010087819 Fc receptors Proteins 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 3
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 3
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 3
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 3
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 3
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108010073466 Bombesin Receptors Proteins 0.000 claims 2
- 102000047481 Gastrin-releasing peptide receptors Human genes 0.000 claims 2
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 108010063954 Mucins Proteins 0.000 claims 2
- 102000015728 Mucins Human genes 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 208000015446 immunoglobulin a vasculitis Diseases 0.000 claims 2
- 238000012737 microarray-based gene expression Methods 0.000 claims 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims 2
- 101150047061 tag-72 gene Proteins 0.000 claims 2
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000002637 immunotoxin Effects 0.000 claims 1
- 229940051026 immunotoxin Drugs 0.000 claims 1
- 239000002596 immunotoxin Substances 0.000 claims 1
- 231100000608 immunotoxin Toxicity 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26807501P | 2001-02-12 | 2001-02-12 | |
| US33895601P | 2001-11-05 | 2001-11-05 | |
| PCT/US2002/004024 WO2002064634A2 (en) | 2001-02-12 | 2002-02-11 | Human monoclonal antibodies to fc alpha receptor (cd89) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009187733A Division JP2010004888A (ja) | 2001-02-12 | 2009-08-13 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005507635A JP2005507635A (ja) | 2005-03-24 |
| JP2005507635A5 true JP2005507635A5 (cg-RX-API-DMAC7.html) | 2005-12-22 |
Family
ID=26952868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002564963A Pending JP2005507635A (ja) | 2001-02-12 | 2002-02-11 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
| JP2009187733A Withdrawn JP2010004888A (ja) | 2001-02-12 | 2009-08-13 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009187733A Withdrawn JP2010004888A (ja) | 2001-02-12 | 2009-08-13 | Ｆｃα受容体（ＣＤ８９）に対するヒトモノクローナル抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7192582B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1370588A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2005507635A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100890088B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1312181C (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002240338C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2437814C (cg-RX-API-DMAC7.html) |
| IL (2) | IL157274A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA03007144A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ527977A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002064634A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200305996B (cg-RX-API-DMAC7.html) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192584B2 (en) * | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| EP1372717A2 (en) * | 2001-03-23 | 2004-01-02 | Aphton Corporation | Combination treatment of pancreatic cancer |
| US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| US20030021786A1 (en) * | 2001-07-09 | 2003-01-30 | Gevas Philip C. | Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus |
| US20060165675A1 (en) * | 2002-08-02 | 2006-07-27 | Richman-Eisenstat Janice Beth | Modulation of mesenchymal cells via iga-receptors |
| EP1608984A2 (en) * | 2003-03-28 | 2005-12-28 | Aphton Corporation | Gastrin hormone immunoassays |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| EP1570858A1 (en) | 2004-03-05 | 2005-09-07 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Monovalent ligand of the FCalphaRi receptor as an anti-inflammatory agent |
| AU2005228897B2 (en) * | 2004-03-29 | 2009-12-10 | Cancer Advances, Inc. | Monoclonal antibodies to gastrin hormone |
| US8158128B2 (en) | 2004-09-22 | 2012-04-17 | Cancer Advances, Inc. | Monoclonal antibodies to progastrin |
| DK1874821T3 (da) | 2005-04-26 | 2013-07-08 | Trion Pharma Gmbh | Kombination af antistoffer med glykokortikoider til behandling af kræft |
| DK2298815T3 (en) | 2005-07-25 | 2015-06-15 | Emergent Product Dev Seattle | B-CELL REDUCTION USING CD37 SPECIFIC AND CD20 SPECIFIC BINDING MOLECULES |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| WO2009025364A1 (ja) | 2007-08-23 | 2009-02-26 | Mitsubishi Kagaku Iatron, Inc. | 非特異反応抑制剤 |
| RS51975B (sr) | 2008-04-11 | 2012-02-29 | Emergent Product Development Seattle Llc. | Cd37 imunoterapeutski proizvod i njegova kombinacija sa bifunkcionalnim hemoterapeutskim sredstvom |
| EP2127666A1 (en) | 2008-05-28 | 2009-12-02 | Drug Discovery Factory B.V. | Method for the treatment or prophylaxis of chronic inflammatory diseases |
| WO2011088219A2 (en) * | 2010-01-13 | 2011-07-21 | The Uab Research Foundation | Therapeutics and processes for treatment of immune disorders |
| US9169325B2 (en) | 2010-04-13 | 2015-10-27 | Celldex Therapeutics, Inc. | Antibodies that bind human CD27 and uses thereof |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9518087B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| EP2465536A1 (en) * | 2010-12-14 | 2012-06-20 | CSL Behring AG | CD89 activation in therapy |
| AU2013216863B2 (en) * | 2012-02-10 | 2018-09-06 | Seagen Inc. | Detection and treatment of CD30+ cancers |
| EP2636684A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Prevention of infection |
| PL2822967T3 (pl) | 2012-03-09 | 2020-01-31 | Csl Behring Ag | Kompozycje zawierające immunoglobuliny typu wydzielniczego |
| EP2636681A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Process for enriching IgA |
| CN106456743A (zh) | 2014-02-21 | 2017-02-22 | 洛桑聚合联合学院 | 糖靶向性治疗剂 |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| WO2016150496A1 (en) * | 2015-03-25 | 2016-09-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anti-cd89 cytotoxic complex |
| JOP20200312A1 (ar) | 2015-06-26 | 2017-06-16 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
| EP3352760A4 (en) | 2015-09-21 | 2019-03-06 | Aptevo Research and Development LLC | CD3-BINDING POLYPEPTIDES |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| JP7083819B2 (ja) * | 2016-09-30 | 2022-06-13 | セントレ ナショナル デ ラ レセルシュ シャンティフィク | 細胞マーカー |
| US12188935B2 (en) | 2016-09-30 | 2025-01-07 | Centre National De La Recherche Scientifique | Method for the evaluation of antiretroviral therapy (ART) effectiveness in HIV-1 CD4+CD89+ cellular reservoirs |
| CN110087530A (zh) | 2016-12-07 | 2019-08-02 | 普罗根尼蒂公司 | 胃肠道检测方法、装置和系统 |
| AU2017383232B2 (en) | 2016-12-23 | 2024-09-12 | Novartis Ag | Factor XI antibodies and methods of use |
| EP4108183A1 (en) | 2017-03-30 | 2022-12-28 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| US12150978B2 (en) | 2017-06-15 | 2024-11-26 | Cancer Advances Inc. | Compositions and methods for preventing tumors and cancer |
| WO2018232230A1 (en) | 2017-06-15 | 2018-12-20 | Cancer Advances Inc. | Compositions and methods for inducing humoral and cellular immunities against tumors and cancer |
| EP3638296A1 (en) | 2017-06-16 | 2020-04-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| AU2018290228B2 (en) | 2017-06-21 | 2021-07-01 | Gilead Sciences, Inc. | Multispecific antibodies that target HIV gp120 and CD3 |
| KR20210011919A (ko) | 2018-04-17 | 2021-02-02 | 셀덱스 쎄라퓨틱스, 인크. | 항-cd27 항체 및 항-pd-l1 항체 및 이중특이적 작제물 |
| KR20210010879A (ko) | 2018-05-09 | 2021-01-28 | 더 유니버서티 오브 시카고 | 면역 관용 관여 조성물 및 방법 |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| CN116726362A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2021215919A1 (en) * | 2020-04-21 | 2021-10-28 | Polpharma Biologics Utrecht B.V. | Humanized anti-human cd89 antibodies and uses thereof |
| US20230365709A1 (en) | 2020-10-08 | 2023-11-16 | Affimed Gmbh | Trispecific binders |
| EP4242233A4 (en) * | 2020-11-06 | 2025-01-15 | Korea University Research and Business Foundation | FC ALPHA RECEPTOR BINDING ANTIBODIES |
| KR102855679B1 (ko) * | 2020-11-06 | 2025-09-04 | 고려대학교 산학협력단 | Fc 알파 수용체 결합 항체 |
| KR102766045B1 (ko) * | 2020-11-06 | 2025-02-10 | 고려대학교 산학협력단 | Fc 알파 수용체 결합력이 향상된 항체 |
| KR102853685B1 (ko) * | 2020-11-06 | 2025-09-01 | 고려대학교 산학협력단 | Fc 알파 수용체 결합력이 증진된 항체 |
| WO2023007023A1 (en) | 2021-07-30 | 2023-02-02 | Affimed Gmbh | Duplexbodies |
| WO2024218512A1 (en) | 2023-04-19 | 2024-10-24 | Centessa Pharmaceuticals (Uk) Limited | Activatable bispecific anti-cd89 and anti-pd-l1 proteins and uses thereof |
| CN117890576A (zh) * | 2023-12-12 | 2024-04-16 | 深圳市陆为生物技术有限公司 | 一种检测CD89-IgA免疫复合物的试剂、方法及其应用 |
| WO2025218725A1 (zh) * | 2024-04-18 | 2025-10-23 | 徕特康(苏州)生物制药有限公司 | 靶向cd20和cd89的髓细胞衔接子抗体及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005805A1 (en) * | 1989-10-20 | 1991-05-02 | Trustees Of Dartmouth College | MONOCLONAL ANTIBODY SPECIFIC FOR IgA RECEPTOR |
| US6018031A (en) * | 1989-10-20 | 2000-01-25 | Trustees Of Dartmouth College | Binding agents specific for IgA receptor |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5198342A (en) * | 1990-07-05 | 1993-03-30 | Immunex Corporation | DNA encoding IgA Fc receptors |
| WO1992003918A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5922845A (en) * | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| WO2001009186A2 (en) * | 1999-07-30 | 2001-02-08 | Medarex, Inc. | Therapeutic compounds comprised of anti-fc receptor binding agents |
| CA2408594A1 (en) | 2000-05-08 | 2001-11-15 | Medarex, Inc. | Human monoclonal antibodies to dendritic cells |
-
2002
- 2002-02-11 AU AU2002240338A patent/AU2002240338C1/en not_active Ceased
- 2002-02-11 MX MXPA03007144A patent/MXPA03007144A/es active IP Right Grant
- 2002-02-11 EP EP02706236A patent/EP1370588A2/en not_active Withdrawn
- 2002-02-11 JP JP2002564963A patent/JP2005507635A/ja active Pending
- 2002-02-11 US US10/073,644 patent/US7192582B2/en not_active Expired - Fee Related
- 2002-02-11 IL IL15727402A patent/IL157274A0/xx unknown
- 2002-02-11 KR KR1020037010590A patent/KR100890088B1/ko not_active Expired - Fee Related
- 2002-02-11 CN CNB028078381A patent/CN1312181C/zh not_active Expired - Fee Related
- 2002-02-11 WO PCT/US2002/004024 patent/WO2002064634A2/en not_active Ceased
- 2002-02-11 CA CA002437814A patent/CA2437814C/en not_active Expired - Fee Related
- 2002-02-11 NZ NZ527977A patent/NZ527977A/en unknown
-
2003
- 2003-08-04 ZA ZA2003/05996A patent/ZA200305996B/en unknown
- 2003-08-06 IL IL157274A patent/IL157274A/en not_active IP Right Cessation
-
2009
- 2009-08-13 JP JP2009187733A patent/JP2010004888A/ja not_active Withdrawn
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