JP2005506355A - （４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成 - Google Patents

（４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成 Download PDF

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Publication number
JP2005506355A
JP2005506355A JP2003536205A JP2003536205A JP2005506355A JP 2005506355 A JP2005506355 A JP 2005506355A JP 2003536205 A JP2003536205 A JP 2003536205A JP 2003536205 A JP2003536205 A JP 2003536205A JP 2005506355 A JP2005506355 A JP 2005506355A
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JP
Japan
Prior art keywords
formula
compound
acid
solvent
isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003536205A
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English (en)
Japanese (ja)
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JP2005506355A5 (enExample
Inventor
ジョージ エス． ケー． ウォン，
ジェオンハン パーク，
ウェイドン トン，
ラマニ ラグハバン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2005506355A publication Critical patent/JP2005506355A/ja
Publication of JP2005506355A5 publication Critical patent/JP2005506355A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
JP2003536205A 2001-10-15 2002-10-15 （４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成 Pending JP2005506355A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32956201P 2001-10-15 2001-10-15
PCT/US2002/032761 WO2003033465A1 (en) 2001-10-15 2002-10-15 Synthesis of (4-bromophenyl) (4-piperidyl)methanone-(z)-o-ethyloxime and salts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009119322A Division JP2009173688A (ja) 2001-10-15 2009-05-15 （４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成

Publications (2)

Publication Number Publication Date
JP2005506355A true JP2005506355A (ja) 2005-03-03
JP2005506355A5 JP2005506355A5 (enExample) 2006-01-05

Family

ID=23285983

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003536205A Pending JP2005506355A (ja) 2001-10-15 2002-10-15 （４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成
JP2009119322A Withdrawn JP2009173688A (ja) 2001-10-15 2009-05-15 （４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009119322A Withdrawn JP2009173688A (ja) 2001-10-15 2009-05-15 （４−ブロモフェニル）（４−ピペリジル）メタノン−（ｚ）−ｏ−エチルオキシムおよび塩の合成

Country Status (9)

Country Link
US (2) US6914142B2 (enExample)
EP (1) EP1436262A1 (enExample)
JP (2) JP2005506355A (enExample)
CN (1) CN1308308C (enExample)
AR (1) AR036882A1 (enExample)
CA (1) CA2463506C (enExample)
MX (1) MXPA04003478A (enExample)
WO (1) WO2003033465A1 (enExample)
ZA (1) ZA200402068B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6914142B2 (en) * 2001-10-15 2005-07-05 Schering Corporation Synthesis of (4-bromopnenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts
US10710977B2 (en) * 2017-02-08 2020-07-14 Nissan Chemical Corporation Method for producing geometrical isomer of oximino compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197469A (ja) * 1987-12-17 1989-08-09 Merrell Dow Pharmaceut Inc ピペリジニル化合物類
WO2000066559A1 (en) * 1999-05-04 2000-11-09 Schering Corporation Piperidine derivatives useful as ccr5 antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408054A (en) * 1981-11-12 1983-10-04 Hoechst-Roussel Pharmaceuticals Inc. Oximes of 4-benzoyl-piperidines
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
US6642385B2 (en) * 2001-10-15 2003-11-04 Schering Corporation Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
US6914142B2 (en) * 2001-10-15 2005-07-05 Schering Corporation Synthesis of (4-bromopnenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197469A (ja) * 1987-12-17 1989-08-09 Merrell Dow Pharmaceut Inc ピペリジニル化合物類
WO2000066559A1 (en) * 1999-05-04 2000-11-09 Schering Corporation Piperidine derivatives useful as ccr5 antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6009001281, Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 2001, Ｖｏｌ．４４， Ｎｏ．２１, ｐ．３３３９−３３４２ *

Also Published As

Publication number Publication date
MXPA04003478A (es) 2004-07-30
US7524963B2 (en) 2009-04-28
JP2009173688A (ja) 2009-08-06
EP1436262A1 (en) 2004-07-14
WO2003033465A1 (en) 2003-04-24
AR036882A1 (es) 2004-10-13
CN1571768A (zh) 2005-01-26
CN1308308C (zh) 2007-04-04
US20050171159A1 (en) 2005-08-04
CA2463506A1 (en) 2003-04-24
CA2463506C (en) 2011-01-04
US20030092731A1 (en) 2003-05-15
ZA200402068B (en) 2005-04-28
US6914142B2 (en) 2005-07-05

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