CA2463506C - Synthesis of (4-bromophenyl) (4-piperidyl)methanone-(z)-o-ethyloxime and salts - Google Patents

Synthesis of (4-bromophenyl) (4-piperidyl)methanone-(z)-o-ethyloxime and salts Download PDF

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Publication number
CA2463506C
CA2463506C CA2463506A CA2463506A CA2463506C CA 2463506 C CA2463506 C CA 2463506C CA 2463506 A CA2463506 A CA 2463506A CA 2463506 A CA2463506 A CA 2463506A CA 2463506 C CA2463506 C CA 2463506C
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CA
Canada
Prior art keywords
compound
formula
acid
solvent
isomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2463506A
Other languages
English (en)
French (fr)
Other versions
CA2463506A1 (en
Inventor
George S. K. Wong
Jeonghan Park
Weidong Tong
Ramani Raghavan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2463506A1 publication Critical patent/CA2463506A1/en
Application granted granted Critical
Publication of CA2463506C publication Critical patent/CA2463506C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CA2463506A 2001-10-15 2002-10-15 Synthesis of (4-bromophenyl) (4-piperidyl)methanone-(z)-o-ethyloxime and salts Expired - Fee Related CA2463506C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32956201P 2001-10-15 2001-10-15
US60/329,562 2001-10-15
PCT/US2002/032761 WO2003033465A1 (en) 2001-10-15 2002-10-15 Synthesis of (4-bromophenyl) (4-piperidyl)methanone-(z)-o-ethyloxime and salts

Publications (2)

Publication Number Publication Date
CA2463506A1 CA2463506A1 (en) 2003-04-24
CA2463506C true CA2463506C (en) 2011-01-04

Family

ID=23285983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2463506A Expired - Fee Related CA2463506C (en) 2001-10-15 2002-10-15 Synthesis of (4-bromophenyl) (4-piperidyl)methanone-(z)-o-ethyloxime and salts

Country Status (9)

Country Link
US (2) US6914142B2 (enExample)
EP (1) EP1436262A1 (enExample)
JP (2) JP2005506355A (enExample)
CN (1) CN1308308C (enExample)
AR (1) AR036882A1 (enExample)
CA (1) CA2463506C (enExample)
MX (1) MXPA04003478A (enExample)
WO (1) WO2003033465A1 (enExample)
ZA (1) ZA200402068B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6914142B2 (en) * 2001-10-15 2005-07-05 Schering Corporation Synthesis of (4-bromopnenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts
US10710977B2 (en) * 2017-02-08 2020-07-14 Nissan Chemical Corporation Method for producing geometrical isomer of oximino compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408054A (en) * 1981-11-12 1983-10-04 Hoechst-Roussel Pharmaceuticals Inc. Oximes of 4-benzoyl-piperidines
US5093341A (en) * 1987-12-17 1992-03-03 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine derivatives useful as antithrombolytic agents
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
CN1524527A (zh) 1999-05-04 2004-09-01 ���鹫˾ 用作ccr5拮抗剂的哌啶衍生物
US6642385B2 (en) * 2001-10-15 2003-11-04 Schering Corporation Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
US6914142B2 (en) * 2001-10-15 2005-07-05 Schering Corporation Synthesis of (4-bromopnenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts

Also Published As

Publication number Publication date
MXPA04003478A (es) 2004-07-30
US7524963B2 (en) 2009-04-28
JP2009173688A (ja) 2009-08-06
EP1436262A1 (en) 2004-07-14
WO2003033465A1 (en) 2003-04-24
AR036882A1 (es) 2004-10-13
JP2005506355A (ja) 2005-03-03
CN1571768A (zh) 2005-01-26
CN1308308C (zh) 2007-04-04
US20050171159A1 (en) 2005-08-04
CA2463506A1 (en) 2003-04-24
US20030092731A1 (en) 2003-05-15
ZA200402068B (en) 2005-04-28
US6914142B2 (en) 2005-07-05

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