CN1308308C - (4－溴苯基)(4－哌啶)亚甲基－(z)－o－乙基肟及其盐的合成 - Google Patents

(4－溴苯基)(4－哌啶)亚甲基－(z)－o－乙基肟及其盐的合成 Download PDF

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Publication number
CN1308308C
CN1308308C CNB028203720A CN02820372A CN1308308C CN 1308308 C CN1308308 C CN 1308308C CN B028203720 A CNB028203720 A CN B028203720A CN 02820372 A CN02820372 A CN 02820372A CN 1308308 C CN1308308 C CN 1308308C
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CN
China
Prior art keywords
compound
formula
isomer
solvent
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028203720A
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English (en)
Chinese (zh)
Other versions
CN1571768A (zh
Inventor
G·S·K·王
J·白
W·童
R·拉哈文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1571768A publication Critical patent/CN1571768A/zh
Application granted granted Critical
Publication of CN1308308C publication Critical patent/CN1308308C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CNB028203720A 2001-10-15 2002-10-15 (4－溴苯基)(4－哌啶)亚甲基－(z)－o－乙基肟及其盐的合成 Expired - Fee Related CN1308308C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32956201P 2001-10-15 2001-10-15
US60/329,562 2001-10-15

Publications (2)

Publication Number Publication Date
CN1571768A CN1571768A (zh) 2005-01-26
CN1308308C true CN1308308C (zh) 2007-04-04

Family

ID=23285983

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028203720A Expired - Fee Related CN1308308C (zh) 2001-10-15 2002-10-15 (4－溴苯基)(4－哌啶)亚甲基－(z)－o－乙基肟及其盐的合成

Country Status (9)

Country Link
US (2) US6914142B2 (enExample)
EP (1) EP1436262A1 (enExample)
JP (2) JP2005506355A (enExample)
CN (1) CN1308308C (enExample)
AR (1) AR036882A1 (enExample)
CA (1) CA2463506C (enExample)
MX (1) MXPA04003478A (enExample)
WO (1) WO2003033465A1 (enExample)
ZA (1) ZA200402068B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6914142B2 (en) * 2001-10-15 2005-07-05 Schering Corporation Synthesis of (4-bromopnenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts
US10710977B2 (en) * 2017-02-08 2020-07-14 Nissan Chemical Corporation Method for producing geometrical isomer of oximino compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408054A (en) * 1981-11-12 1983-10-04 Hoechst-Roussel Pharmaceuticals Inc. Oximes of 4-benzoyl-piperidines
WO2000066559A1 (en) * 1999-05-04 2000-11-09 Schering Corporation Piperidine derivatives useful as ccr5 antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093341A (en) * 1987-12-17 1992-03-03 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine derivatives useful as antithrombolytic agents
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
US6642385B2 (en) * 2001-10-15 2003-11-04 Schering Corporation Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
US6914142B2 (en) * 2001-10-15 2005-07-05 Schering Corporation Synthesis of (4-bromopnenyl)(4-piperidyl)methanone-(Z)-O-ethyloxime and salts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408054A (en) * 1981-11-12 1983-10-04 Hoechst-Roussel Pharmaceuticals Inc. Oximes of 4-benzoyl-piperidines
US4408054B1 (enExample) * 1981-11-12 1987-06-02
WO2000066559A1 (en) * 1999-05-04 2000-11-09 Schering Corporation Piperidine derivatives useful as ccr5 antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SYNTHE SIS AND NEUROLEPTIC ACTIVITY OF 3 1-SUBSTITUTED-4-PIPERIDIN-YL-1 2-BENZISOXAZOLES STRUPCZEWSKI J T ET AL,JOURNAL OF MEDICIN AL CHEMISTRY,Vol.28 No.6 1985 *

Also Published As

Publication number Publication date
MXPA04003478A (es) 2004-07-30
US6914142B2 (en) 2005-07-05
US7524963B2 (en) 2009-04-28
CA2463506A1 (en) 2003-04-24
EP1436262A1 (en) 2004-07-14
US20050171159A1 (en) 2005-08-04
JP2005506355A (ja) 2005-03-03
US20030092731A1 (en) 2003-05-15
AR036882A1 (es) 2004-10-13
JP2009173688A (ja) 2009-08-06
CN1571768A (zh) 2005-01-26
ZA200402068B (en) 2005-04-28
WO2003033465A1 (en) 2003-04-24
CA2463506C (en) 2011-01-04

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070404

Termination date: 20111015