JP2005505621A5 - - Google Patents
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- Publication number
- JP2005505621A5 JP2005505621A5 JP2003536206A JP2003536206A JP2005505621A5 JP 2005505621 A5 JP2005505621 A5 JP 2005505621A5 JP 2003536206 A JP2003536206 A JP 2003536206A JP 2003536206 A JP2003536206 A JP 2003536206A JP 2005505621 A5 JP2005505621 A5 JP 2005505621A5
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydropyridine
- trifluoromethylphenyl
- ethyl
- formula
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000012453 solvate Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- PDVIVNQWSPMKSC-UHFFFAOYSA-N 1-[2-(2,3-dihydro-1h-inden-5-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4CCCC4=CC=3)CC=2)=C1 PDVIVNQWSPMKSC-UHFFFAOYSA-N 0.000 claims description 2
- -1 2,3-dihydro-1H-cyclopenta [b] naphthalen-6-yl Chemical group 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 150000001204 N-oxides Chemical class 0.000 claims 7
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- UVWNGBKIJKCUIE-UHFFFAOYSA-N 1-[2-(2,3-dihydro-1h-cyclopenta[a]naphthalen-8-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=5CCCC=5C=CC4=CC=3)CC=2)=C1 UVWNGBKIJKCUIE-UHFFFAOYSA-N 0.000 claims 1
- HZRQALJMGLKQNH-UHFFFAOYSA-N 1-[2-(2,3-dihydro-1h-cyclopenta[b]naphthalen-6-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=C5CCCC5=CC4=CC=3)CC=2)=C1 HZRQALJMGLKQNH-UHFFFAOYSA-N 0.000 claims 1
- LZCZYYPTSZSHTO-UHFFFAOYSA-N 1-[2-(5,6,7,8-tetrahydroanthracen-2-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=C5CCCCC5=CC4=CC=3)CC=2)=C1 LZCZYYPTSZSHTO-UHFFFAOYSA-N 0.000 claims 1
- NECUMARVLDJDAX-UHFFFAOYSA-N 1-[2-(5,6,7,8-tetrahydronaphthalen-2-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4CCCCC4=CC=3)CC=2)=C1 NECUMARVLDJDAX-UHFFFAOYSA-N 0.000 claims 1
- CEURLLWBMBECFZ-UHFFFAOYSA-N 1-[2-(5,6,7,8-tetrahydrophenanthren-3-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=5CCCCC=5C=CC4=CC=3)CC=2)=C1 CEURLLWBMBECFZ-UHFFFAOYSA-N 0.000 claims 1
- KJOBKJBALVLTTK-UHFFFAOYSA-N 1-[2-(9,10-dihydrophenanthren-2-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C(C5=CC=CC=C5CC4)=CC=3)CC=2)=C1 KJOBKJBALVLTTK-UHFFFAOYSA-N 0.000 claims 1
- PGGACCXMNDVRAG-UHFFFAOYSA-N 1-[2-(9h-fluoren-2-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C(C5=CC=CC=C5C4)=CC=3)CC=2)=C1 PGGACCXMNDVRAG-UHFFFAOYSA-N 0.000 claims 1
- SHTVDYCXLBULOF-UHFFFAOYSA-N 1-[2-(9h-fluoren-3-yl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C5=CC=CC=C5CC4=CC=3)CC=2)=C1 SHTVDYCXLBULOF-UHFFFAOYSA-N 0.000 claims 1
- AGQPGLHGZIFSPE-UHFFFAOYSA-N 1-[3-(2,3-dihydro-1h-inden-5-yl)propyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCCC=3C=C4CCCC4=CC=3)CC=2)=C1 AGQPGLHGZIFSPE-UHFFFAOYSA-N 0.000 claims 1
- FCMYDFIHAZCWBF-UHFFFAOYSA-N 1-[4-(2,3-dihydro-1h-inden-5-yl)butyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCCCC=3C=C4CCCC4=CC=3)CC=2)=C1 FCMYDFIHAZCWBF-UHFFFAOYSA-N 0.000 claims 1
- ZVSARLBVFTYSTB-UHFFFAOYSA-N 2-[1-[2-(2,3-dihydro-1h-cyclopenta[b]naphthalen-6-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=C5CCCC5=CC4=CC=3)CC=2)=N1 ZVSARLBVFTYSTB-UHFFFAOYSA-N 0.000 claims 1
- YYHUTONOCGMNPE-UHFFFAOYSA-N 2-chloro-6-[1-[2-(2,3-dihydro-1h-cyclopenta[b]naphthalen-6-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]pyridine Chemical compound ClC1=CC=CC(C=2CCN(CCC=3C=C4C=C5CCCC5=CC4=CC=3)CC=2)=N1 YYHUTONOCGMNPE-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical compound ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 150000008065 acid anhydrides Chemical class 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- RTZOHLHIHBLFAU-UHFFFAOYSA-N 2-(9h-fluoren-3-yl)acetonitrile Chemical compound C1=CC=C2C3=CC(CC#N)=CC=C3CC2=C1 RTZOHLHIHBLFAU-UHFFFAOYSA-N 0.000 description 1
- IFYKRMQORZOMNY-UHFFFAOYSA-N 4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine Chemical class FC(F)(F)C1=CC=CC(C=2CCNCC=2)=C1 IFYKRMQORZOMNY-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0113469A FR2831166B1 (fr) | 2001-10-18 | 2001-10-18 | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
| PCT/FR2002/003508 WO2003033466A1 (fr) | 2001-10-18 | 2002-10-14 | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010033642A Division JP2010120961A (ja) | 2001-10-18 | 2010-02-18 | アラルキルテトラヒドロピリジンを含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005505621A JP2005505621A (ja) | 2005-02-24 |
| JP2005505621A5 true JP2005505621A5 (cg-RX-API-DMAC10.html) | 2006-01-05 |
| JP4524107B2 JP4524107B2 (ja) | 2010-08-11 |
Family
ID=8868455
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003536206A Expired - Fee Related JP4524107B2 (ja) | 2001-10-18 | 2002-10-14 | アラルキルテトラヒドロピリジン、それらの製造およびそれらを含む医薬組成物 |
| JP2010033642A Withdrawn JP2010120961A (ja) | 2001-10-18 | 2010-02-18 | アラルキルテトラヒドロピリジンを含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010033642A Withdrawn JP2010120961A (ja) | 2001-10-18 | 2010-02-18 | アラルキルテトラヒドロピリジンを含む医薬組成物 |
Country Status (21)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA75980C2 (en) | 2001-10-15 | 2006-06-15 | Janssen Pharmaceutica Nv | Substituted 4-pheny1-4-[1h-imidazol-2-yl] piperidine derivative for reducing ischaemic damages |
| MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
| CN100526301C (zh) * | 2003-12-26 | 2009-08-12 | 卫材R&D管理有限公司 | 1,2-二(环式基)取代苯化合物 |
| US20060276465A1 (en) * | 2003-12-26 | 2006-12-07 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic) substituted benzene compounds |
| US7410971B2 (en) | 2003-12-26 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
| CN101068798B (zh) | 2004-12-20 | 2010-05-12 | 卫材R&D管理有限公司 | 1-环丙基甲基-4-[2-(3,3,5,5-四甲基环己基)苯基]哌嗪的盐及结晶 |
| MY144974A (en) * | 2005-06-14 | 2011-11-30 | Eisai R&D Man Co Ltd | 1,2-di(cyclic) substituted benzene derivatives |
| US9608205B2 (en) | 2005-09-15 | 2017-03-28 | Lg Chem, Ltd. | Organic compound and organic light emitting device using the same |
| US8298683B2 (en) * | 2005-09-15 | 2012-10-30 | Lg Chem, Ltd. | Organic compound and organic light emitting device using the same |
| US9493383B2 (en) | 2005-09-15 | 2016-11-15 | Lg Chem, Ltd. | Organic compound and organic light emitting device using the same |
| CN102099458A (zh) * | 2008-06-05 | 2011-06-15 | 威斯康星医学院公司 | 用于高通量试验的三维组织 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3804878A (en) * | 1969-09-08 | 1974-04-16 | Ciba Geigy Corp | Hydrogenated araliphatic acids |
| EP0447116B1 (en) * | 1990-03-12 | 1994-12-14 | Yamanouchi Pharmaceutical Co. Ltd. | Urea derivatives, their production, and pharmaceutical compositions containing them |
| FR2662442A1 (fr) * | 1990-05-23 | 1991-11-29 | Midy Spa | Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant. |
| AU2808495A (en) * | 1994-07-04 | 1996-01-25 | Takeda Chemical Industries Ltd. | Phosphonic acid compounds, their production and use |
| FR2734819B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
| FR2762514B1 (fr) * | 1997-04-29 | 1999-10-22 | Sanofi Sa | Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation |
| FR2763847B1 (fr) * | 1997-05-28 | 2003-06-06 | Sanofi Sa | Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1 |
| US6070784A (en) * | 1998-07-08 | 2000-06-06 | The Boeing Company | Contact backup roller approach to FSW process |
| US6509351B1 (en) * | 1999-10-22 | 2003-01-21 | Sanofi-Syntelabo | Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity |
| ES2302992T3 (es) * | 1999-12-30 | 2008-08-01 | H. Lundbeck A/S | Derivados de 4-fenil-piperazinil, -piperidinil y tetrahidropiridil como antagonistas de dopamina d4. |
| FR2803593B1 (fr) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| DE60220779T2 (de) * | 2001-04-20 | 2008-03-06 | Sanofi-Aventis | Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten |
| FR2823749B1 (fr) * | 2001-04-20 | 2004-02-20 | Sanofi Synthelabo | Phenyl- et pyridyl-piperidines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| JP3687912B2 (ja) * | 2002-08-29 | 2005-08-24 | 東芝テック株式会社 | プリンタユニット |
-
2001
- 2001-10-18 FR FR0113469A patent/FR2831166B1/fr not_active Expired - Fee Related
-
2002
- 2002-10-14 EP EP02795311A patent/EP1438291B1/fr not_active Expired - Lifetime
- 2002-10-14 WO PCT/FR2002/003508 patent/WO2003033466A1/fr not_active Ceased
- 2002-10-14 AU AU2002360117A patent/AU2002360117B2/en not_active Ceased
- 2002-10-14 HU HU0401713A patent/HUP0401713A3/hu unknown
- 2002-10-14 KR KR1020047005587A patent/KR100935787B1/ko not_active Expired - Fee Related
- 2002-10-14 BR BR0213359-8A patent/BR0213359A/pt not_active Application Discontinuation
- 2002-10-14 JP JP2003536206A patent/JP4524107B2/ja not_active Expired - Fee Related
- 2002-10-14 CN CNA2007101368627A patent/CN101096337A/zh active Pending
- 2002-10-14 US US10/492,770 patent/US7326723B2/en not_active Expired - Fee Related
- 2002-10-14 CA CA2460822A patent/CA2460822C/en not_active Expired - Fee Related
- 2002-10-14 DE DE60206068T patent/DE60206068T2/de not_active Expired - Lifetime
- 2002-10-14 PL PL02368802A patent/PL368802A1/xx not_active IP Right Cessation
- 2002-10-14 NZ NZ531846A patent/NZ531846A/en not_active IP Right Cessation
- 2002-10-14 EA EA200400323A patent/EA007324B1/ru not_active IP Right Cessation
- 2002-10-14 IL IL16082002A patent/IL160820A0/xx unknown
- 2002-10-14 AT AT02795311T patent/ATE303991T1/de not_active IP Right Cessation
- 2002-10-14 CN CNB028207548A patent/CN100335464C/zh not_active Expired - Fee Related
- 2002-10-14 MX MXPA04003568A patent/MXPA04003568A/es active IP Right Grant
-
2004
- 2004-03-10 IL IL160820A patent/IL160820A/en not_active IP Right Cessation
- 2004-03-11 IS IS7181A patent/IS2486B/is unknown
- 2004-03-15 ZA ZA200402059A patent/ZA200402059B/en unknown
- 2004-04-16 NO NO20041573A patent/NO326490B1/no not_active IP Right Cessation
-
2007
- 2007-12-18 US US11/958,476 patent/US7858824B2/en not_active Expired - Fee Related
-
2010
- 2010-02-18 JP JP2010033642A patent/JP2010120961A/ja not_active Withdrawn
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