JP2005505286A5 - - Google Patents

Info

Publication number

JP2005505286A5

JP2005505286A5 JP2003534559A JP2003534559A JP2005505286A5 JP 2005505286 A5 JP2005505286 A5 JP 2005505286A5 JP 2003534559 A JP2003534559 A JP 2003534559A JP 2003534559 A JP2003534559 A JP 2003534559A JP 2005505286 A5 JP2005505286 A5 JP 2005505286A5

Authority

JP

Japan

Prior art keywords

region

base pairs

nucleic acid

seq

linked

Prior art date

2002-10-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000007523 nucleic acids Chemical class 0.000 claims 71
• 108020004707 nucleic acids Proteins 0.000 claims 70
• 102000039446 nucleic acids Human genes 0.000 claims 70
• 241000701161 unidentified adenovirus Species 0.000 claims 30
• 230000014509 gene expression Effects 0.000 claims 25
• 239000002773 nucleotide Substances 0.000 claims 24
• 125000003729 nucleotide group Chemical group 0.000 claims 24
• 230000008488 polyadenylation Effects 0.000 claims 14
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 13
• 229920001184 polypeptide Polymers 0.000 claims 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims 10
• 108091026890 Coding region Proteins 0.000 claims 9
• 108010006025 bovine growth hormone Proteins 0.000 claims 8
• 239000013612 plasmid Substances 0.000 claims 8
• 241000701022 Cytomegalovirus Species 0.000 claims 7
• 239000003550 marker Substances 0.000 claims 5
• 230000010076 replication Effects 0.000 claims 5
• 108010076039 Polyproteins Proteins 0.000 claims 4
• 101800001554 RNA-directed RNA polymerase Proteins 0.000 claims 4
• 238000012217 deletion Methods 0.000 claims 4
• 230000037430 deletion Effects 0.000 claims 4
• 239000013598 vector Substances 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 2
• 230000006801 homologous recombination Effects 0.000 claims 2
• 238000002744 homologous recombination Methods 0.000 claims 2
• 210000005260 human cell Anatomy 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000013605 shuttle vector Substances 0.000 claims 2
• 230000003612 virological effect Effects 0.000 claims 2
• 241000282412 Homo Species 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 108020004412 RNA 3' Polyadenylation Signals Proteins 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 229940065638 intron a Drugs 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1