JP2005504790A5 - - Google Patents
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- Publication number
- JP2005504790A5 JP2005504790A5 JP2003526409A JP2003526409A JP2005504790A5 JP 2005504790 A5 JP2005504790 A5 JP 2005504790A5 JP 2003526409 A JP2003526409 A JP 2003526409A JP 2003526409 A JP2003526409 A JP 2003526409A JP 2005504790 A5 JP2005504790 A5 JP 2005504790A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- group
- unsubstituted
- alkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000001931 aliphatic group Chemical group 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 7
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- -1 N-morpholino, pyrimidyl Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32202201P | 2001-09-13 | 2001-09-13 | |
| PCT/US2002/027513 WO2003022280A2 (en) | 2001-09-13 | 2002-08-28 | 3-glyoxlylamideindoles for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504790A JP2005504790A (ja) | 2005-02-17 |
| JP2005504790A5 true JP2005504790A5 (enExample) | 2006-01-05 |
Family
ID=23253062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003526409A Pending JP2005504790A (ja) | 2001-09-13 | 2002-08-28 | 癌を治療するための３−グリオキシリルアミドインドール |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6958348B2 (enExample) |
| EP (1) | EP1427416A2 (enExample) |
| JP (1) | JP2005504790A (enExample) |
| AU (1) | AU2002323474B2 (enExample) |
| CA (1) | CA2460347A1 (enExample) |
| WO (1) | WO2003022280A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10022925A1 (de) * | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
| AU2002323474B2 (en) * | 2001-09-13 | 2006-10-05 | Synta Pharmaceuticals Corp | 3-glyoxlylamideindoles for treating cancer |
| US6903104B2 (en) | 2001-12-06 | 2005-06-07 | National Health Research Institutes | Indol-3-YL-2-oxoacetamide compounds and methods of use thereof |
| EP1484329A1 (de) * | 2003-06-06 | 2004-12-08 | Zentaris GmbH | Indolderivate mit Apoptose induzierender Wirkung |
| EP1595878A1 (de) * | 2004-05-15 | 2005-11-16 | Zentaris GmbH | Indolderivate mit Apoptose induzierender Wirkung |
| JP4878285B2 (ja) * | 2003-06-05 | 2012-02-15 | エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | アポトーシス誘発作用を有するインドール誘導体 |
| US7205299B2 (en) | 2003-06-05 | 2007-04-17 | Zentaris Gmbh | Indole derivatives having an apoptosis-inducing effect |
| DE10334040A1 (de) * | 2003-07-25 | 2005-03-10 | Zentaris Gmbh | Neue N-substituierte Indolyl-3-glyoxylsäureamide, deren Verwendung als Arzneimittel und Verfahren zu deren Herstellung |
| US7211588B2 (en) | 2003-07-25 | 2007-05-01 | Zentaris Gmbh | N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation |
| DE102005026194A1 (de) * | 2005-06-06 | 2006-12-07 | Grünenthal GmbH | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| CA2660704A1 (en) * | 2006-08-07 | 2008-02-14 | Ironwood Pharmaceuticals, Inc. | Indole compounds |
| CA2759176C (en) | 2009-04-29 | 2016-03-15 | Amarin Corporation Plc | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| CN112574192B (zh) * | 2020-12-24 | 2021-10-01 | 烟台大学 | 氨基酸衍生联噻唑-色胺类抗癌化合物和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965582A (en) * | 1994-08-03 | 1999-10-12 | Asta Medica Aktiengesellschaft | N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect |
| DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
| EA003876B1 (ru) | 1998-02-25 | 2003-10-30 | Дженетикс Инститьют, Ллс | Ингибиторы фосфолипазных ферментов |
| US6500853B1 (en) * | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| WO2000021563A1 (en) | 1998-10-14 | 2000-04-20 | Shionogi & Co., Ltd. | Remedies or preventives for ischemic reflow failure |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| WO2000067802A1 (en) * | 1999-05-10 | 2000-11-16 | Protarga, Inc. | Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof |
| CN1310906C (zh) * | 1999-05-21 | 2007-04-18 | 肖斯公司 | 用作p38激酶抑制剂的吲哚类型的衍生物 |
| US6500583B1 (en) * | 2000-07-17 | 2002-12-31 | Energy Conversion Devices, Inc. | Electrochemical hydrogen storage alloys for nickel metal hydride batteries, fuel cells and methods of manufacturing same |
| IT1318641B1 (it) * | 2000-07-25 | 2003-08-27 | Novuspharma Spa | Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale. |
| DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
| AU2002323474B2 (en) * | 2001-09-13 | 2006-10-05 | Synta Pharmaceuticals Corp | 3-glyoxlylamideindoles for treating cancer |
| US6903104B2 (en) * | 2001-12-06 | 2005-06-07 | National Health Research Institutes | Indol-3-YL-2-oxoacetamide compounds and methods of use thereof |
-
2002
- 2002-08-28 AU AU2002323474A patent/AU2002323474B2/en not_active Ceased
- 2002-08-28 EP EP02757457A patent/EP1427416A2/en not_active Withdrawn
- 2002-08-28 WO PCT/US2002/027513 patent/WO2003022280A2/en not_active Ceased
- 2002-08-28 JP JP2003526409A patent/JP2005504790A/ja active Pending
- 2002-08-28 CA CA002460347A patent/CA2460347A1/en not_active Abandoned
- 2002-08-29 US US10/232,394 patent/US6958348B2/en not_active Expired - Fee Related
-
2005
- 2005-05-24 US US11/136,074 patent/US20060004044A1/en not_active Abandoned
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