JP2005504086A - １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法 - Google Patents

１７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法 Download PDF

Info

Publication number
JP2005504086A
JP2005504086A JP2003530210A JP2003530210A JP2005504086A JP 2005504086 A JP2005504086 A JP 2005504086A JP 2003530210 A JP2003530210 A JP 2003530210A JP 2003530210 A JP2003530210 A JP 2003530210A JP 2005504086 A JP2005504086 A JP 2005504086A
Authority
JP
Japan
Prior art keywords
aag
protic solvent
ansamycin
volatile
melting point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003530210A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005504086A5 (OSRAM
Inventor
ジャン，リン
ボエーム，マーカス，エフ
ゼガー，シード
Original Assignee
コンフォーマ セラピューティクス コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by コンフォーマ セラピューティクス コーポレーション filed Critical コンフォーマ セラピューティクス コーポレーション
Publication of JP2005504086A publication Critical patent/JP2005504086A/ja
Publication of JP2005504086A5 publication Critical patent/JP2005504086A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2003530210A 2001-09-24 2002-09-18 １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法 Pending JP2005504086A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32663901P 2001-09-24 2001-09-24
US33189301P 2001-11-21 2001-11-21
PCT/US2002/029715 WO2003026571A2 (en) 2001-09-24 2002-09-18 Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins

Publications (2)

Publication Number Publication Date
JP2005504086A true JP2005504086A (ja) 2005-02-10
JP2005504086A5 JP2005504086A5 (OSRAM) 2005-12-22

Family

ID=26985493

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003530210A Pending JP2005504086A (ja) 2001-09-24 2002-09-18 １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法

Country Status (9)

Country Link
US (1) US7579462B2 (OSRAM)
EP (1) EP1435939B1 (OSRAM)
JP (1) JP2005504086A (OSRAM)
KR (1) KR20040054692A (OSRAM)
CN (1) CN100378079C (OSRAM)
AT (1) ATE387198T1 (OSRAM)
CA (1) CA2460498A1 (OSRAM)
DE (1) DE60225307T2 (OSRAM)
WO (1) WO2003026571A2 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010512397A (ja) * 2006-12-12 2010-04-22 インフィニティ・ディスカバリー・インコーポレイテッド アンサマイシン製剤およびその使用法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
JP2005504086A (ja) 2001-09-24 2005-02-10 コンフォーマ セラピューティクス コーポレーション １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法
WO2003037860A2 (en) 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
CA2474508A1 (en) 2002-02-08 2003-08-14 Conforma Therapeutics Corporation Ansamycins having improved pharmacological and biological properties
US7138401B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity
CN102643233B (zh) 2003-12-23 2015-11-25 无限发现公司 用于治疗癌症的包含苯醌的安沙霉素类似物
KR101045324B1 (ko) * 2004-08-11 2011-06-30 한국생명공학연구원 젤다나마이신 유도체 및 그 생합성 방법
US7371906B2 (en) * 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
WO2006089207A2 (en) * 2005-02-18 2006-08-24 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
CA2602257A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
CA2603462A1 (en) * 2005-04-07 2006-10-09 Conforma Therapeutics Corporation Phospholipid-based pharmaceutical formulations and methods for producing and using same
US7648976B2 (en) * 2005-11-23 2010-01-19 Bristol-Myers Squibb Company 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
US20090042847A1 (en) * 2005-11-23 2009-02-12 Kosan Biosciences Incorporated 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
CN101360492A (zh) * 2005-12-01 2009-02-04 康福玛医药公司 含安莎霉素的组合物
KR100796637B1 (ko) * 2006-09-29 2008-01-22 한국생명공학연구원 젤다나마이신 유도체, 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 및치료제
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
KR100861697B1 (ko) * 2007-01-30 2008-10-07 한국생명공학연구원 Ａｈｂａ 생합성 유전자 변이주를 이용한 안사마이신유도체의 생산 방법 및 신규한 안사마이신 유도체
WO2010045442A1 (en) 2008-10-15 2010-04-22 Infinity Discovery, Inc. Ansamycin hydroquinone compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
CA2127457A1 (en) 1992-01-06 1993-07-22 Walter P. Cullen Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
EP0706516A1 (en) 1993-06-29 1996-04-17 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
EP1169319A4 (en) 1999-04-09 2005-02-09 Sloan Kettering Institutefor C METHODS AND COMPOSITIONS FOR DEGRADING AND / OR INHIBITING TYROSINE KINASES BELONGING TO THE HER FAMILY
JP2005504086A (ja) 2001-09-24 2005-02-10 コンフォーマ セラピューティクス コーポレーション １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010512397A (ja) * 2006-12-12 2010-04-22 インフィニティ・ディスカバリー・インコーポレイテッド アンサマイシン製剤およびその使用法

Also Published As

Publication number Publication date
DE60225307D1 (de) 2008-04-10
US20050176695A1 (en) 2005-08-11
WO2003026571A3 (en) 2003-10-02
EP1435939A2 (en) 2004-07-14
ATE387198T1 (de) 2008-03-15
CA2460498A1 (en) 2003-04-03
EP1435939B1 (en) 2008-02-27
WO2003026571A2 (en) 2003-04-03
CN1558757A (zh) 2004-12-29
CN100378079C (zh) 2008-04-02
US7579462B2 (en) 2009-08-25
KR20040054692A (ko) 2004-06-25
EP1435939A4 (en) 2004-12-29
DE60225307T2 (de) 2009-03-19

Similar Documents

Publication Publication Date Title
JP2005504086A (ja) １７−アリルアミノゲルダナマイシン（１７−ａａｇ）および他のアンサマイシン類を製造する方法
US20080214617A1 (en) Carbamate compounds
CN114149476B (zh) 一种核糖核苷类似物的多晶型物、其制备方法及应用
WO2024008129A1 (zh) 作为kat6抑制剂的化合物
CN111196790B (zh) 新型紫杉烷类衍生物及其药物组合物和用途
US20080027223A1 (en) Polymorphs of eszopiclone malate
US20210214309A1 (en) New Crystal Form Of Lenvatinib Mesylate And Preparation Method Therefor
CN111689905A (zh) 一种奥拉帕尼与马来酸的共晶及其制备方法
RU2719484C2 (ru) Натриевая соль ингибитора транспортера мочевой кислоты и его кристаллическая форма
EP2688649B1 (en) A polymorph of lenalidomide
Feth et al. From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor
EP1923061A1 (en) Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins
CN114437076A (zh) 一种酮咯酸与异烟肼共晶及其制备方法
WO2010146595A2 (en) Novel polymorphs of flibanserin hydrochloride
WO2016101412A1 (zh) 一种无结晶水二丁酰环磷腺苷钙晶型及其制备方法和应用
AU2002326973A1 (en) Process for preparing 17-allyl amino geldanamycin (17-AAG) and other ansamycins
HK1120411A (en) Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
KR102665004B1 (ko) 5-메틸-(6s)-테트라히드로폴산의 결정질 소듐 염
EP1548015A1 (en) Novel crystals
EP3098220A1 (en) Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
Chen et al. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on related heterocycle-fused naphthoquinones for cancer therapy
WO2011055233A2 (en) Improved process for preparing celecoxib polymorph
CN109232585B (zh) 一种多取代嘧啶并二吲哚酮衍生物的制备方法
EP3636655A1 (en) Crystal form of fatty acid bile acid conjugate, method for preparing same, and application
CN101230040A (zh) 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050915

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090526

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20091201