JP2005503434A - ３−デスオキシ−ビタミンｄ３類似体 - Google Patents

３−デスオキシ−ビタミンｄ３類似体 Download PDF

Info

Publication number
JP2005503434A
JP2005503434A JP2003530656A JP2003530656A JP2005503434A JP 2005503434 A JP2005503434 A JP 2005503434A JP 2003530656 A JP2003530656 A JP 2003530656A JP 2003530656 A JP2003530656 A JP 2003530656A JP 2005503434 A JP2005503434 A JP 2005503434A
Authority
JP
Japan
Prior art keywords
compound
group
formula
alkyl
desoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003530656A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005503434A5 (ru
Inventor
ウスココヴィック，ミラン・ラドージェ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2005503434A publication Critical patent/JP2005503434A/ja
Publication of JP2005503434A5 publication Critical patent/JP2005503434A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2003530656A 2001-09-21 2002-09-12 ３−デスオキシ−ビタミンｄ３類似体 Pending JP2005503434A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32395701P 2001-09-21 2001-09-21
US32387001P 2001-09-21 2001-09-21
PCT/EP2002/010233 WO2003027065A1 (en) 2001-09-21 2002-09-12 3-desoxy-vitamin d3 analog esters

Publications (2)

Publication Number Publication Date
JP2005503434A true JP2005503434A (ja) 2005-02-03
JP2005503434A5 JP2005503434A5 (ru) 2005-12-08

Family

ID=26984180

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003530656A Pending JP2005503434A (ja) 2001-09-21 2002-09-12 ３−デスオキシ−ビタミンｄ３類似体

Country Status (14)

Country Link
EP (1) EP1430026A1 (ru)
JP (1) JP2005503434A (ru)
KR (1) KR100628586B1 (ru)
CN (1) CN1285573C (ru)
AU (1) AU2002338672B2 (ru)
BR (1) BR0212719A (ru)
CA (1) CA2459789A1 (ru)
MX (1) MXPA04002640A (ru)
PA (1) PA8554901A1 (ru)
PE (1) PE20030429A1 (ru)
PL (1) PL370352A1 (ru)
RU (1) RU2296121C2 (ru)
UY (1) UY27448A1 (ru)
WO (1) WO2003027065A1 (ru)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503880A (ja) * 2002-10-23 2006-02-02 レオ・ファーマ・アクティーゼルスカブ ビタミンｄ類似体、該類似体を含んで成る組成物およびその使用
JP2008514621A (ja) * 2004-09-24 2008-05-08 ビオクセル エッセ ピ ア ２０−シクロアルキル，２６，２７−アルキル／ハロアルキル−ビタミンｄ３化合物及びその使用方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
CN102124301B (zh) 2008-08-22 2014-04-02 Nxp股份有限公司 基于位置的服务
CN110339205B (zh) * 2019-08-19 2021-08-24 山东德信生物科技有限公司 富氢水组合物在抑制六价铬诱导的df-1细胞内质网应激及自噬中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006503880A (ja) * 2002-10-23 2006-02-02 レオ・ファーマ・アクティーゼルスカブ ビタミンｄ類似体、該類似体を含んで成る組成物およびその使用
JP2008514621A (ja) * 2004-09-24 2008-05-08 ビオクセル エッセ ピ ア ２０−シクロアルキル，２６，２７−アルキル／ハロアルキル−ビタミンｄ３化合物及びその使用方法

Also Published As

Publication number Publication date
UY27448A1 (es) 2003-03-31
RU2004112217A (ru) 2005-07-10
BR0212719A (pt) 2004-08-03
PE20030429A1 (es) 2003-05-15
CN1285573C (zh) 2006-11-22
PA8554901A1 (es) 2003-12-10
CN1556795A (zh) 2004-12-22
AU2002338672B2 (en) 2006-03-09
MXPA04002640A (es) 2004-06-07
EP1430026A1 (en) 2004-06-23
PL370352A1 (en) 2005-05-16
WO2003027065A1 (en) 2003-04-03
CA2459789A1 (en) 2003-04-03
KR20040035853A (ko) 2004-04-29
RU2296121C2 (ru) 2007-03-27
KR100628586B1 (ko) 2006-09-26

Similar Documents

Publication Publication Date Title
JP4493340B2 (ja) １α−ヒドロキシ−２−メチレン−１９−ノル−プレグナカルシフェロール及びその使用
US5872113A (en) Fluorinated vitamin D3 analogs
JP2004505022A (ja) 骨強度を増加するための２−メチレン−１９−ノル−２０（Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用
EP1015423B1 (en) 1,3-dihydroxy-20,20-dialkyl-vitamin d 3? analogs
HRP980224A2 (en) Vitamin d3 analogs with bis c-20 side chains
JP2007530421A (ja) （２０Ｓ）−１α−ヒドロキシ−２−メチレン−１９−ノル−ビタミンＤ３及びその使用
KR100351490B1 (ko) 비스 씨-20 측쇄를 갖는 비타민 디3 유사체
JP2005503434A (ja) ３−デスオキシ−ビタミンｄ３類似体
US6559138B1 (en) 3-Desoxy-vitamin D3 analog esters
CA2205315C (en) Fluorinated vitamin d3 analogs
AU2002338672A1 (en) 3-desoxy-vitamin D3 analog esters
US7491711B2 (en) Methods of treatment using 3-desoxy vitamin D3 analogs
RU2223953C2 (ru) Аналоги витамина D, фармацевтическая композиция, соединения
US5696103A (en) Method for treating osteoporosis
JP4619360B2 (ja) ２−メチレン−１９−ノル−２０（Ｓ）−２５−メチル−１α−ヒドロキシカルシフェロール及びその使用
Manchand et al. Method of using Vitamin D3 analogs with BIS C-20 side chains
Manchand et al. Vitamin D3 analogs with BIS C-20 side chains

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070410

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070709

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070717

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20071211