JP2005501857A5 - - Google Patents
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- Publication number
- JP2005501857A5 JP2005501857A5 JP2003521237A JP2003521237A JP2005501857A5 JP 2005501857 A5 JP2005501857 A5 JP 2005501857A5 JP 2003521237 A JP2003521237 A JP 2003521237A JP 2003521237 A JP2003521237 A JP 2003521237A JP 2005501857 A5 JP2005501857 A5 JP 2005501857A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- sodium salt
- temperature
- fusion
- crystalline sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940126062 Compound A Drugs 0.000 claims 13
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 13
- 159000000000 sodium salts Chemical class 0.000 claims 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 230000004927 fusion Effects 0.000 claims 8
- 239000013078 crystal Substances 0.000 claims 4
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31337301P | 2001-08-17 | 2001-08-17 | |
| PCT/US2002/025675 WO2003016315A1 (en) | 2001-08-17 | 2002-08-13 | Sodium salt of an hiv integrase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501857A JP2005501857A (ja) | 2005-01-20 |
| JP2005501857A5 true JP2005501857A5 (https=) | 2006-01-05 |
Family
ID=23215462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003521237A Withdrawn JP2005501857A (ja) | 2001-08-17 | 2002-08-13 | Ｈｉｖインテグラーゼ阻害剤のナトリウム塩 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6924282B2 (https=) |
| EP (1) | EP1430058A1 (https=) |
| JP (1) | JP2005501857A (https=) |
| AR (1) | AR036256A1 (https=) |
| CA (1) | CA2456206A1 (https=) |
| DO (1) | DOP2002000449A (https=) |
| WO (1) | WO2003016315A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL360944A1 (en) * | 2000-10-12 | 2004-09-20 | Merck & Co, Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| ATE409187T1 (de) * | 2002-03-15 | 2008-10-15 | Merck & Co Inc | N-(substituierte benzyl)-8-hydroxy-1,6- naphthyridin-7- carbonsäureamide als hiv- integrase-hemmer |
| WO2005009962A1 (en) * | 2003-07-15 | 2005-02-03 | Merck & Co., Inc. | Hydroxypyridine cgrp receptor antagonists |
| CA2537325A1 (en) * | 2003-09-19 | 2005-03-31 | Gilead Sciences, Inc. | Aza-quinolinol phosphonate integrase inhibitor compounds |
| WO2005117904A2 (en) * | 2004-04-14 | 2005-12-15 | Gilead Sciences, Inc. | Phosphonate analogs of hiv integrase inhibitor compounds |
| JP2010504978A (ja) | 2006-09-29 | 2010-02-18 | アイデニクス ファーマシューティカルズ，インコーポレーテッド | Ｈｉｖ阻害剤としての鏡像異性的に純粋なホスホインドール |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2632639B1 (fr) * | 1988-06-09 | 1990-10-05 | Sanofi Sa | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent |
| IL101860A0 (en) * | 1991-05-31 | 1992-12-30 | Ici Plc | Heterocyclic derivatives |
| US5681832A (en) | 1995-02-17 | 1997-10-28 | The United States Of America As Represented By The Department Of Health And Human Services | Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity |
| US5945431A (en) * | 1996-03-15 | 1999-08-31 | Biochem Therapeutics Incorporated | Cytomegalovirus inhibiting compounds |
| US6310211B1 (en) * | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| WO1998013350A1 (en) | 1996-09-25 | 1998-04-02 | Zeneca Limited | Qinoline derivatives inhibiting the effect of growth factors such as vegf |
| DE69828284T2 (de) * | 1997-06-30 | 2005-12-08 | Nippon Kayaku K.K. | Naphthyridinderivate oder salze davon |
| KR20010023313A (ko) | 1997-08-25 | 2001-03-26 | 해피 페너 ; 해리 에이치. 페너 2세 | Ｇａｂａ 뇌 수용체 리간드로서의 치환된4-옥소-나프티리딘-3-카르복스아미드 |
| PL341364A1 (en) | 1997-12-22 | 2001-04-09 | Upjohn Co | 4-hydroxyqinoline-3-carboxamides and hydrazides as antiviral agents |
| US6306891B1 (en) * | 1998-06-03 | 2001-10-23 | Merck & Co., Inc. | HIV integrase inhibitors |
| US6262055B1 (en) * | 1998-06-03 | 2001-07-17 | Merck & Co., Inc. | HIV integrase inhibitors |
| US6380249B1 (en) * | 1998-06-03 | 2002-04-30 | Merck & Co., Inc. | HIV integrase inhibitors |
| AU5880600A (en) | 1999-06-25 | 2001-01-31 | Merck & Co., Inc. | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
| US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| PL360944A1 (en) * | 2000-10-12 | 2004-09-20 | Merck & Co, Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| IL161337A0 (en) | 2001-10-26 | 2004-09-27 | Angeletti P Ist Richerche Bio | N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase |
| ATE355064T1 (de) | 2001-10-26 | 2006-03-15 | Angeletti P Ist Richerche Bio | Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase |
-
2002
- 2002-08-09 AR ARP020103023A patent/AR036256A1/es unknown
- 2002-08-13 CA CA002456206A patent/CA2456206A1/en not_active Abandoned
- 2002-08-13 JP JP2003521237A patent/JP2005501857A/ja not_active Withdrawn
- 2002-08-13 EP EP02794880A patent/EP1430058A1/en not_active Withdrawn
- 2002-08-13 WO PCT/US2002/025675 patent/WO2003016315A1/en not_active Ceased
- 2002-08-14 US US10/218,537 patent/US6924282B2/en not_active Expired - Fee Related
- 2002-08-15 DO DO2002000449A patent/DOP2002000449A/es unknown
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