JP2005501857A - Ｈｉｖインテグラーゼ阻害剤のナトリウム塩 - Google Patents

Ｈｉｖインテグラーゼ阻害剤のナトリウム塩 Download PDF

Info

Publication number
JP2005501857A
JP2005501857A JP2003521237A JP2003521237A JP2005501857A JP 2005501857 A JP2005501857 A JP 2005501857A JP 2003521237 A JP2003521237 A JP 2003521237A JP 2003521237 A JP2003521237 A JP 2003521237A JP 2005501857 A JP2005501857 A JP 2005501857A
Authority
JP
Japan
Prior art keywords
compound
sodium salt
subject
aids
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2003521237A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005501857A5 (enExample
Inventor
アンソニー，ネビル・ジエイ
シユー，ウエイ
レポー，ジヨン・ブイ
マハジヤン，アマール・ジエイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2005501857A publication Critical patent/JP2005501857A/ja
Publication of JP2005501857A5 publication Critical patent/JP2005501857A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2003521237A 2001-08-17 2002-08-13 Ｈｉｖインテグラーゼ阻害剤のナトリウム塩 Withdrawn JP2005501857A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31337301P 2001-08-17 2001-08-17
PCT/US2002/025675 WO2003016315A1 (en) 2001-08-17 2002-08-13 Sodium salt of an hiv integrase inhibitor

Publications (2)

Publication Number Publication Date
JP2005501857A true JP2005501857A (ja) 2005-01-20
JP2005501857A5 JP2005501857A5 (enExample) 2006-01-05

Family

ID=23215462

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003521237A Withdrawn JP2005501857A (ja) 2001-08-17 2002-08-13 Ｈｉｖインテグラーゼ阻害剤のナトリウム塩

Country Status (7)

Country Link
US (1) US6924282B2 (enExample)
EP (1) EP1430058A1 (enExample)
JP (1) JP2005501857A (enExample)
AR (1) AR036256A1 (enExample)
CA (1) CA2456206A1 (enExample)
DO (1) DOP2002000449A (enExample)
WO (1) WO2003016315A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ525088A (en) * 2000-10-12 2004-11-26 Merck & Co Inc Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
AU2003220170B2 (en) * 2002-03-15 2008-12-11 Merck Sharp & Dohme Corp. N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as HIV integrase inhibitors
CA2532064A1 (en) * 2003-07-15 2005-02-03 Merck & Co., Inc. Hydroxypyridine cgrp receptor antagonists
US20070185007A1 (en) * 2003-09-19 2007-08-09 Haolun Jin Aza-quinolinol phosphonate integrase inhibitor compounds
DE602005010413D1 (de) * 2004-04-14 2008-11-27 Zhenhong R Cai Phosphonatanaloga von hiv-integrasehemmerverbindungen
NZ575831A (en) 2006-09-29 2011-12-22 Idenix Pharmaceuticals Inc Enantiomerically pure phosphoindoles as hiv inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2632639B1 (fr) 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
IL101860A0 (en) 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
US5681832A (en) 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
US6310211B1 (en) * 1996-09-10 2001-10-30 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
ATE300521T1 (de) 1996-09-25 2005-08-15 Astrazeneca Ab Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern
KR20010014262A (ko) 1997-06-30 2001-02-26 닛뽄카야쿠가부시키가이샤 신규 나프티리딘 유도체 또는 그 염
SI20270A (sl) 1997-08-25 2000-12-31 Neurogen Corporation Substituirani 4-okso-naftiridin-3-karboksamidi kot ligandi možganskih GABA receptorjev
US6093732A (en) 1997-12-22 2000-07-25 Pharmacia & Upjohn Company 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
AU5880600A (en) 1999-06-25 2001-01-31 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
NZ525088A (en) * 2000-10-12 2004-11-26 Merck & Co Inc Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
DE60218511T2 (de) 2001-10-26 2007-10-25 Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
EP1441735B1 (en) 2001-10-26 2006-02-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase

Also Published As

Publication number Publication date
DOP2002000449A (es) 2003-05-15
EP1430058A1 (en) 2004-06-23
WO2003016315A1 (en) 2003-02-27
US20030119823A1 (en) 2003-06-26
CA2456206A1 (en) 2003-02-27
US6924282B2 (en) 2005-08-02
AR036256A1 (es) 2004-08-25

Similar Documents

Publication Publication Date Title
JP4705956B2 (ja) Ｈｉｖインテグラーゼ阻害剤のカリウム塩
CA2574220C (en) Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
CA2549606C (en) Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
US20090105203A1 (en) Compounds for treating viral infections
JP5639762B2 (ja) ウイルス阻害剤
JP2014510139A (ja) 固体形態のｈｉｖ阻害剤
KR20050087865A (ko) ＨＩＶ 인테그라제 억제제로서 유용한테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘 및 관련화합물
JP2010506913A (ja) Ｈｉｖインテグラーゼ阻害剤
TW200819126A (en) HIV integrase inhibitors
IL297041A (en) Inhibitors of human immunodeficiency virus replication
JP2023513018A (ja) アルファ－１アンチトリプシン欠乏症の治療方法
JP2005501857A (ja) Ｈｉｖインテグラーゼ阻害剤のナトリウム塩
TWI384986B (zh) 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
JPH11500130A (ja) 抗ウイルス性トリアザ化合物
TWI462915B (zh) 一種組織胺ｈ３受體拮抗劑的新穎富馬酸鹽
US20130040914A1 (en) Prodrugs of an hiv reverse transcriptase inhibitor
US6071916A (en) HIV protease inhibitor
AU730245B2 (en) Sulfate salt of an HIV protease inhibitor having an improved oral absorption and bioavailability
US20060100432A1 (en) Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
WO2006107478A2 (en) Crystalline sodium salt of an hiv integrase inhibitor
CN118388405A (zh) 一种酰肼类化合物、其组合物及其用途
CN120192315A (zh) 一种抗包虫病药物及其制备方法和应用
US20060211687A1 (en) Potassium salt of an hiv integrase inhibitor
EA042617B1 (ru) АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННЫЙ ПРЕПАРАТ ДЛЯ ТЕРАПИИ ВИЧа И СПИДа
CZ425199A3 (cs) Sulfát inhibitoru HIV proteázy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050801

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050801

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20070219