CA2456206A1 - Sodium salt of an hiv integrase inhibitor - Google Patents

Sodium salt of an hiv integrase inhibitor Download PDF

Info

Publication number
CA2456206A1
CA2456206A1 CA002456206A CA2456206A CA2456206A1 CA 2456206 A1 CA2456206 A1 CA 2456206A1 CA 002456206 A CA002456206 A CA 002456206A CA 2456206 A CA2456206 A CA 2456206A CA 2456206 A1 CA2456206 A1 CA 2456206A1
Authority
CA
Canada
Prior art keywords
compound
aids
sodium salt
salt
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002456206A
Other languages
English (en)
French (fr)
Inventor
Neville J. Anthony
Wei Xu
John V. Lepore
Amar J. Mahajan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2456206A1 publication Critical patent/CA2456206A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002456206A 2001-08-17 2002-08-13 Sodium salt of an hiv integrase inhibitor Abandoned CA2456206A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31337301P 2001-08-17 2001-08-17
US60/313,373 2001-08-17
PCT/US2002/025675 WO2003016315A1 (en) 2001-08-17 2002-08-13 Sodium salt of an hiv integrase inhibitor

Publications (1)

Publication Number Publication Date
CA2456206A1 true CA2456206A1 (en) 2003-02-27

Family

ID=23215462

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002456206A Abandoned CA2456206A1 (en) 2001-08-17 2002-08-13 Sodium salt of an hiv integrase inhibitor

Country Status (7)

Country Link
US (1) US6924282B2 (enExample)
EP (1) EP1430058A1 (enExample)
JP (1) JP2005501857A (enExample)
AR (1) AR036256A1 (enExample)
CA (1) CA2456206A1 (enExample)
DO (1) DOP2002000449A (enExample)
WO (1) WO2003016315A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155089A0 (en) * 2000-10-12 2003-10-31 Merck & Co Inc Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
WO2003077850A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
CN100418948C (zh) * 2003-07-15 2008-09-17 麦克公司 羟基吡啶cgrp受体抗拮抗剂
EP1664046B1 (en) 2003-09-19 2009-06-17 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
CA2562713A1 (en) * 2004-04-14 2005-12-15 Gilead Sciences, Inc. Phosphonate analogs of hiv integrase inhibitor compounds
BRPI0717511A2 (pt) 2006-09-29 2013-11-19 Idenix Pharmaceuticals Inc Composto puro, composição farmacêutica, métodos para tratar uma infecção por hiv, para prevenir uma infecção por hiv, para inibir a replicação de hiv, e, uso de um composto

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2632639B1 (fr) * 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
IL101860A0 (en) * 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
US5681832A (en) 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
US5945431A (en) * 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
AU4172197A (en) * 1996-09-10 1998-04-02 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
CA2263479A1 (en) 1996-09-25 1998-04-02 Zeneca Limited Quinoline derivatives inhibiting the effect of growth factors such as vegf
AU729995B2 (en) * 1997-06-30 2001-02-22 Nippon Kayaku Kabushiki Kaisha Novel naphthyridine derivatives or salts thereof
NZ502548A (en) 1997-08-25 2002-06-28 Neurogen Corp Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
ATE303993T1 (de) 1997-12-22 2005-09-15 Pharmacia & Upjohn Co Llc 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
US6262055B1 (en) * 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) * 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) * 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
WO2001000578A1 (en) 1999-06-25 2001-01-04 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
IL155089A0 (en) * 2000-10-12 2003-10-31 Merck & Co Inc Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
AU2002334205B2 (en) 2001-10-26 2007-07-05 Istituto Di Ricerche Di Biologia Molecolara P. Angeletti Spa Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
DK1441735T3 (da) 2001-10-26 2006-06-12 Angeletti P Ist Richerche Bio N-substituerede hydroxypyrimidinon-carboxamid-inhibitorer af HIV-integrase

Also Published As

Publication number Publication date
WO2003016315A1 (en) 2003-02-27
EP1430058A1 (en) 2004-06-23
DOP2002000449A (es) 2003-05-15
US6924282B2 (en) 2005-08-02
AR036256A1 (es) 2004-08-25
JP2005501857A (ja) 2005-01-20
US20030119823A1 (en) 2003-06-26

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Legal Events

Date Code Title Description
FZDE Discontinued