CA2456206A1 - Sodium salt of an hiv integrase inhibitor - Google Patents

Sodium salt of an hiv integrase inhibitor Download PDF

Info

Publication number
CA2456206A1
CA2456206A1 CA002456206A CA2456206A CA2456206A1 CA 2456206 A1 CA2456206 A1 CA 2456206A1 CA 002456206 A CA002456206 A CA 002456206A CA 2456206 A CA2456206 A CA 2456206A CA 2456206 A1 CA2456206 A1 CA 2456206A1
Authority
CA
Canada
Prior art keywords
compound
aids
sodium salt
salt
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002456206A
Other languages
English (en)
French (fr)
Inventor
Neville J. Anthony
Wei Xu
John V. Lepore
Amar J. Mahajan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2456206A1 publication Critical patent/CA2456206A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002456206A 2001-08-17 2002-08-13 Sodium salt of an hiv integrase inhibitor Abandoned CA2456206A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31337301P 2001-08-17 2001-08-17
US60/313,373 2001-08-17
PCT/US2002/025675 WO2003016315A1 (en) 2001-08-17 2002-08-13 Sodium salt of an hiv integrase inhibitor

Publications (1)

Publication Number Publication Date
CA2456206A1 true CA2456206A1 (en) 2003-02-27

Family

ID=23215462

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002456206A Abandoned CA2456206A1 (en) 2001-08-17 2002-08-13 Sodium salt of an hiv integrase inhibitor

Country Status (7)

Country Link
US (1) US6924282B2 (enExample)
EP (1) EP1430058A1 (enExample)
JP (1) JP2005501857A (enExample)
AR (1) AR036256A1 (enExample)
CA (1) CA2456206A1 (enExample)
DO (1) DOP2002000449A (enExample)
WO (1) WO2003016315A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002211527B2 (en) * 2000-10-12 2006-08-24 Merck Sharp & Dohme Corp. Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
WO2003077850A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
EP1646611A1 (en) * 2003-07-15 2006-04-19 Merck & Co., Inc. Hydroxypyridine cgrp receptor antagonists
ATE433974T1 (de) * 2003-09-19 2009-07-15 Gilead Sciences Inc Azachinolinolphosphonatverbindungen als integraseinhibitoren
SI1742642T1 (sl) * 2004-04-14 2009-04-30 Gilead Sciences Inc Fosfonatni analogi inhibitorskih spojin HIV integraze
BRPI0717511A2 (pt) 2006-09-29 2013-11-19 Idenix Pharmaceuticals Inc Composto puro, composição farmacêutica, métodos para tratar uma infecção por hiv, para prevenir uma infecção por hiv, para inibir a replicação de hiv, e, uso de um composto

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2632639B1 (fr) 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
AU1625192A (en) 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
US5681832A (en) 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
AU4172197A (en) * 1996-09-10 1998-04-02 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
EP0929526B1 (en) 1996-09-25 2005-07-27 AstraZeneca AB Qinoline derivatives inhibiting the effect of growth factors such as vegf
CA2295309A1 (en) 1997-06-30 1999-01-07 Nippon Kayaku Kabushiki Kaisha Novel naphthyridine derivatives or salts thereof
HUP0003258A3 (en) 1997-08-25 2001-05-28 Neurogen Corp Branford Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
SK9072000A3 (en) 1997-12-22 2001-03-12 Upjohn Co 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
EP1196384A4 (en) 1999-06-25 2002-10-23 Merck & Co Inc 1- (AROMATIC OR HETEROAROMATICALLY SUBSTITUTED) -3- (HETEROAROMATICALLY SUBSTITUTED) -1,3-PROPANDIONS AND THEIR APPLICATIONS
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
AU2002211527B2 (en) * 2000-10-12 2006-08-24 Merck Sharp & Dohme Corp. Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
CN1700918B (zh) 2001-10-26 2011-06-08 P·安杰莱蒂分子生物学研究所 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂
CA2463975A1 (en) 2001-10-26 2003-05-01 Maria Emilia Di Francesco Dihydroxypyrimidine carboxamide inhibitors of hiv integrase

Also Published As

Publication number Publication date
WO2003016315A1 (en) 2003-02-27
US20030119823A1 (en) 2003-06-26
DOP2002000449A (es) 2003-05-15
US6924282B2 (en) 2005-08-02
EP1430058A1 (en) 2004-06-23
AR036256A1 (es) 2004-08-25
JP2005501857A (ja) 2005-01-20

Similar Documents

Publication Publication Date Title
US6919351B2 (en) Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors
EP1819700B1 (en) Potassium salt of an hiv integrase inhibitor
EP1326610B1 (en) Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
EP1467970B1 (en) Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
CA2425440C (en) Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
AU2002215328A1 (en) AZA- and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors
AU2002246499A1 (en) Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
AU2005230878A1 (en) 2-aminothiazole compounds useful as aspartyl protease inhibitors
EP1496836B1 (en) N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
EP1539714B1 (en) 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as hiv integrase inhibitors
US6924282B2 (en) Sodium salt of an HIV integrase inhibitor
US7449476B2 (en) Tetrahydrocarboline antiviral agents
US20030125336A1 (en) Hydrohalide salts of an HIV protease inhibitor
AU2002332521A1 (en) Sodium salt of an HIV integrase inhibitor
US20060211687A1 (en) Potassium salt of an hiv integrase inhibitor

Legal Events

Date Code Title Description
FZDE Discontinued