JP2005334872A - 流体用構成要素およびシステムの表面を親水化する方法 - Google Patents
流体用構成要素およびシステムの表面を親水化する方法 Download PDFInfo
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Abstract
【解決手段】流体用構成要素の内側表面に物理化学的処理、特にプラズマ処理を施し、次いで内側表面を親水性ポリマーの溶液に接触させ、その後、ポリマー溶液を、最初は内側表面がポリマー溶液の一部により濡れたままであるような方法で気体の媒体に置き換え、最後に溶媒を除去することにより流体用構成要素の内側表面に親水性ポリマーの薄膜が残るようにする。この場合に用いられる親水性ポリマーは、流体用構成要素そのものの内側表面の表面湿潤性よりも水溶液に対する高い表面湿潤性を有する。
【選択図】なし
Description
1. まず、流体用構成要素の内側表面に物理化学的処理を施す。
例としてハウジングチャネルを用いたプラズマにより前処理された流体用要素上への親水性ポリマーの薄膜の調製
流体用構成要素の例として、センサー要素、たとえば酸素電極のハウジングチャネルについて以下に記載する。上記のハウジングチャネルは基本的にセンサー要素の液体運搬領域に相当し、液体と直接接触し、特に液体をセンサー要素内に供給し、またそこから除去するサンプルチャネルを含む。図2は、たとえばRoche Diagnostics製のOMNI分析システムに用いられるClark型の酸素センサーを用いるセンサー要素のようなセンサー領域の断面の例を示す。これらのセンサー要素(10)は、内部電解液空間およびこの中に位置する電極を有する実際のセンサー(11)に加えて、サンプルを輸送および供給するサンプルチャネルまたはハウジングチャネル(12)を含む。内部電解液空間およびサンプルチャネルを分離する気体透過性および実質的にイオンおよび液体不透過性のプラスチック膜(13)が内部電解液空間およびサンプルチャネルの間に位置する。この場合、センサー要素のハウジング(15)および同様にハウジングチャネル(12)の壁は、透明なプラスチック、たとえばメチルメタクリレート−ブタジエン−スチレンコポリマーからなる。ヒドロゲルコーティングの実施前にハウジングチャネルを前処理するために、ハウジング(15)を支持プレートに固定して、Plasmafinsh Company製のV15-G型プラズマ装置の中に置き、製造者の指示に従って2.45GHzで数分間、ヘリウムプラズマで処理した。この場合、プラズマは、ハウジングチャネル(12)の両側の開口部ならびに後に膜(13)により覆われるハウジングの開口部を通して、ハウジングチャネルの内側まで達することができる。プラズマ処理が完了した後約5〜60分以内に、プラズマ処理されたハウジングを支持プレートから取り外し、ハウジング支持体に固定する。このハウジング支持体において、液体を供給および排出する液体ラインをハウジングチャネル(12)の両端に連結する。液体ラインは、ハウジング(15)上に存在する圧縮性シール(14)または液体ライン上に存在するシールを介して加圧連結により密封される。親水性ポリマーX1の溶液を、液体ラインを通して、したがってハウジングチャネル(12)を通して数分間吸引する。X1は、たとえばCardio Tech International,
78E Olympia Avenue, Woburn MA 01801-2057, USAより「親水性ポリマーポリウレタン」として入手できるポリエーテル−ポリウレタンコポリマー型の親水性ポリマーを表し、50%の水取り込み率および60%の膨潤による膨張率を有する。親水性ポリマーX1の溶液を調製するために、決められた量のヒドロゲル顆粒X1を撹拌しながらエタノール−水混合物に溶解する。次に、親水性ポリマーX1の溶液を液体ラインおよびハウジングチャネル(12)から除去し、液体ラインおよびハウジングチャネルを通して数分間空気を吸引する。ハウジングチャネル(12)の内側壁上のヒドロゲル層をこのプロセスで乾燥すると、本発明のコーティング法の結果として、ハウジングチャネル(12)の内側壁に親水性ポリマーの薄膜が形成される。
Claims (18)
- 流体用構成要素の内側表面に親水性ポリマーの薄膜を製造する方法であって、上記親水性ポリマーは、親水性ポリマーの薄膜が存在しない場合の流体用構成要素の内側表面の表面湿潤性よりも水溶液に対する高い表面湿潤性を有し、
上記親水性ポリマーの薄膜が以下のように製造される、前記方法:
a) 流体用構成要素の内側表面に物理化学的前処理を施し、
b) 流体用構成要素の内側表面に親水性ポリマーの溶液を接触させ、
c) 親水性ポリマーの溶液を、まず流体用構成要素の内側表面が親水性ポリマーの溶液の一部により濡れたままであるような方法で気体の媒体に置き換え、
d) 溶媒を除去することにより流体用構成要素の内側表面に親水性ポリマーの薄膜を残す。 - 物理化学的前処理がプラズマ処理である、請求項1記載の方法。
- 親水性ポリマーが有機溶媒または溶媒混合物に可溶性で、水溶液に実質的に不溶性である、上記の請求項1または2記載の方法。
- 親水性ポリマーがポリエーテル−ポリウレタンコポリマーである、請求項1〜3のいずれか1項記載の方法。
- 親水性ポリマーの薄膜が、付加的な中間層なしで流体用構成要素の内側表面に直接製造される、請求項1〜4のいずれか1項記載の方法。
- 物理化学的前処理が、内側表面への親水性ポリマーの薄膜の接着、およびその物理的または化学的ストレスに対する抵抗性を改良する、請求項1〜5のいずれか1項記載の方法。
- 内側表面に親水性ポリマーの薄膜を有する流体用構成要素であって、上記親水性ポリマーの薄膜が請求項1〜6のいずれか1項記載の方法により製造されたものである、前記流体用構成要素。
- 流体用構成要素が、要素チャネル、チューブ、パイプ、バルブ、分配器、結合要素、液体受容デバイス、ニップル、センサー要素の液体運搬領域または液体容器を含む群からの構成要素である、請求項7記載の流体用構成要素。
- 流体用構成要素の内側表面が少なくとも1つのプラスチックから構成される、請求項7または8記載の流体用構成要素。
- 親水性ポリマーの薄膜の厚さが、0.01〜50μmの間、好ましくは0.01〜10μmの間、特に好ましくは0.01〜5μmの間である、請求項7〜9のいずれか1項記載の流体用構成要素。
- 液体を輸送するための流体システムであって、流体用構成要素間で液体を輸送できるような方式で連結されたいくつかの流体用構成要素から構成され、かつ請求項7〜10のいずれか1項記載の1つ以上の流体用構成要素を含む、前記流体システム。
- 個々の流体用構成要素の内側表面の物理的特性、特にそれらの湿潤特性が、これらの流体用構成要素の内側表面に同じ親水性ポリマーの薄膜が存在することにより等しくされている、請求項11記載の流体システム。
- まず親水性ポリマーの薄膜を個々の流体用構成要素または該流体用構成要素のより小さい部分組立品の内側表面に製造し、次いでそれらを組み立てて流体システムを形成する、請求項11または12記載の流体システムを製造する方法。
- まず個々の流体用構成要素または該流体用構成要素のより小さい部分組立品の内側表面に請求項1のプロセスステップa)の前処理を実施し、次いでこれらの流体用構成要素または部分組立品を組み立てて流体システムを形成し、この組み立てられた流体システムに請求項1のプロセスステップb)〜d)を実施する、請求項11または12記載の流体システムを製造する方法。
- 液体の少なくとも1つの物理または化学パラメーターを測定するための少なくとも1つのセンサー要素、および液体をセンサー要素におよび/またはセンサー要素から輸送するための流体システムを含む、液体の少なくとも1つの物理または化学パラメーターを測定するための分析システムであって、該流体システムが1つ以上の請求項7〜10のいずれか1項記載の流体用構成要素を含む、前記分析システム。
- 分析される液体が生理的な液体、特に血液、血清、血漿または尿である、請求項15記載の分析システム。
- 親水性ポリマーの薄膜が、分析される液体と直接接触する1つ以上のセンサー要素の液体運搬領域の内側表面にも存在する、請求項15または16記載の分析システム。
- 特に、液体のさまざまな物理および/または化学パラメーターを測定するためのセンサーモジュールの形で、いくつかのセンサー要素を含む、請求項15〜17のいずれか1項記載の分析システム。
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ATE466669T1 (de) | 2010-05-15 |
CN1689711B (zh) | 2014-06-25 |
DE502005009508D1 (de) | 2010-06-17 |
CA2504944A1 (en) | 2005-10-26 |
US8394338B2 (en) | 2013-03-12 |
CA2504944C (en) | 2010-01-12 |
JP4878772B2 (ja) | 2012-02-15 |
ES2344457T3 (es) | 2010-08-27 |
US20050255579A1 (en) | 2005-11-17 |
CN1689711A (zh) | 2005-11-02 |
DK1595605T3 (da) | 2010-08-16 |
EP1595605B1 (de) | 2010-05-05 |
EP1595605A1 (de) | 2005-11-16 |
CA2655062A1 (en) | 2005-10-26 |
CA2655062C (en) | 2013-02-05 |
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