JP2005046640A - 光力学治療のためのバルーンカテーテル - Google Patents
光力学治療のためのバルーンカテーテル Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22057—Optical properties
- A61B2017/22058—Optical properties reflective
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22057—Optical properties
- A61B2017/22059—Optical properties transparent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2261—Optical elements at the distal end of probe tips with scattering, diffusion or dispersion of light
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Abstract
【解決手段】改良された装置は、規定された処置ウィンドウを有するバルーンを含み、ウィンドウの輪郭は反射材料を用いて規定される。装置はさらに、拡散チップ内で終了する光ファイバケーブルを含み得、拡散チップは処置ウィンドウよりも長い。
【選択図】図1
Description
(1)規定された領域に照射を供給する、規定された処置ウィンドウを有するバルーンカテーテルを含む装置であって、
i)光ファイバプローブが挿入され得る透明な中央チャネルと、
ii)上記バルーンを膨張させるために用いる、近位端と遠位端とを有する外部スリーブであって、上記遠位端近傍に膨張可能バルーンをさらに含み、上記バルーンが両端部において、上記処置ウィンドウを規定するために反射材料でコーティングされている、外部スリーブと、
を含む装置。
(2)上記処置ウィンドウが長さ約1cm〜20cmである、項目(2)に記載の装置。
(3)上記バルーン内の上記処置ウィンドウが、円筒形状である、項目(1)に記載の装置。
(4)上記円筒形状処置ウィンドウが、膨張したとき、長さ約3mm〜約200mmであり、直径約1mm〜100mmである、項目(3)に記載の装置。
(5)上記反射コーティングが、TiO2、アルミニウム、銀および金からなる群より選択される、項目(1)に記載の装置。
(6.拡散器内で終了する光ファイバケーブルをさらに含み、上記拡散器が上記処置ウィンドウよりも長い、項目(1)に記載の装置。
(7)上記拡散器が円筒形状拡散器である、項目(6)に記載の装置。
(8)上記拡散器が、上記処置ウィンドウよりも約2cm長い、項目(7)に記載の装置。
(9)上記バルーンが、高密度ポリウレタンにより形成されている、項目(1)に記載の装置。
(10)上記処置ウィンドウが透明である、項目(1)に記載の装置。
(11)上記処置ウィンドウが半透明である、項目(1)に記載の装置。
(12)上記バルーンの壁に取り付けられた1以上の光学センサをさらに含む、項目(1)に記載の装置。
(13)規定された領域に照射を供給する、規定された処置ウィンドウを含む、改良されたバルーンカテーテル装置であって、上記改良が、上記処置ウィンドウを規定するために反射材料を用いることを含む、装置。
(14)規定された領域に照射を供給する、規定された処置ウィンドウを含む、改良されたバルーンカテーテル装置であって、上記改良が、上記処置ウィンドウよりも長い光ファイバ拡散チップを含む、装置。
(15)規定された領域に照射を供給する、規定された処置ウィンドウを含む、改良されたバルーンカテーテル装置であって、上記改良が、上記処置ウィンドウを規定するための反射材料、および上記処置ウィンドウよりも長い光ファイバ拡散チップを用いることを含む、装置。
(16)規定された標的領域に光を照射する、または光力学治療(PDT)に用いる、改良された方法であって、上記改良が、項目(1)に記載のバルーンカテーテルを用いることを含む、方法。
(17)レーザー光源として、約1.5W未満のレーザーダイオードが用いられる、項目(16)に記載の方法。
(18)規定された標的領域に光を照射する、または光力学治療(PDT)に用いる、改良された方法であって、上記改良が、項目(6)に記載のバルーンカテーテルを用いることを含む、方法。
(19)レーザー光源として、約1.5W未満のレーザーダイオードが用いられる、項目(18)に記載の方法。
以下のデータは、本明細書において開示するバルーンカテーテルと、OverholtらのLasers and Surgery in Medicine 14: 27−33(1994)に実質的に記載されているバルーンカテーテルとの比較を提供するものである。このデータは、黒色端部(B)あるいは反射性白色端部(W)を有するバルーンを、バルーンの壁部にシミュレーションとしての組織反射器有りまたは無しの条件下(紙:無、あるいは、紙:白と呼称する)で用いて行われた研究を、要約している。さらに、異なるバルーンウィンドウ長さ/光ファイバ拡散器長さの比較を提供する。
275×(1.1/3.6)=84J/cm
しか使わないことを非常に重要に意味している。これは、利点として2通りに使用され得る。現存のバルーンカテーテル(黒色端部)の場合、典型的に、400mW/cmが用いられ、結果的に、275J/cmに対して処置時間は11.5分となる。反射性端部バルーンおよび処置ウィンドウよりも長い拡散器チップを用いた場合、処置時間が低減される(例えば、200mW/cmで7分)か、あるいは、mW/cmが84mW/cmまで低減され得る。後者は、9cmの拡散器を使用している場合でも安価なレーザーダイオード(光ファイバにおいて30%の損失があると仮定した場合1.1Wのレーザーダイオードが必要)を使用することが可能になるので、極めて重要である。
反射コートされたTiO2白色端部バルーン(Polymer Technology Groupにより提供された)を用いて以下のデータが得られた。
図16および図17は、異なるウィンドウサイズ/拡散器サイズの組み合わせによって得られた、処置ウィンドウを介した光の均一性を比較するために用いられ得るグラフィカルスキャンを提示する。図16は、拡散器およびバルーンウィンドウの長さが均等である場合のスキャンを示す。図17は、拡散器の長さがバルーンウィンドウよりも2cm長い場合のスキャンを示す。スキャンは両方とも、組織散乱効果をシミュレートするために白色散乱紙の存在下で行った。
Claims (20)
- 規定された領域に照射を供給する、規定された処置ウィンドウを有するバルーンカテーテルを含む装置であって、以下:
i)光ファイバプローブが挿入され得る透明な中央チャネル;
ii)該バルーンを膨張させるために用いる、近位端と遠位端とを有する外部スリーブであって、該遠位端近傍に膨張可能バルーンをさらに含む、外部スリーブ;および
iii)拡散器内で終了する光ファイバケーブルであって、該拡散器が該処置ウィンドウよりも長い、光ファイバケーブル、
を含み、このことによって、処置領域における光の分配の効率および均一性を向上する、装置。 - 前記処置ウィンドウが長さ約1cm〜20cmである、請求項1に記載の装置。
- 前記バルーン内の前記処置ウィンドウが、円筒形状である、請求項1に記載の装置。
- 前記円筒形状処置ウィンドウが、膨張したとき、長さ約3mm〜約200mmであり、直径約1mm〜100mmである、請求項3に記載の装置。
- 前記バルーンが、高密度ポリウレタンにより形成されている、請求項1に記載の装置。
- 前記処置ウィンドウが透明である、請求項1に記載の装置。
- 前記処置ウィンドウが半透明である、請求項1に記載の装置。
- 前記バルーンの壁に取り付けられた1以上の光学センサをさらに含む、請求項1に記載の装置。
- レーザー光源として、約1.5W未満のレーザーダイオードが用いられる、請求項1に記載の装置。
- 規定された領域に照射を供給する、規定された処置ウィンドウを有するバルーンカテーテルを含む装置であって、以下:
i)光ファイバプローブが挿入され得る透明な中央チャネル;および
ii)該バルーンを膨張させるために用いる、近位端と遠位端とを有する外部スリーブであって、該遠位端近傍に膨張可能バルーンをさらに含む、外部スリーブ;
を含み、ここで、該バルーンが両端部において、該処置ウィンドウを規定するために反射材料でコーティングされており、このことによって、処置領域における光の分配の効率および均一性を向上する、装置。 - 前記処置ウィンドウが長さ約1cm〜20cmである、請求項10に記載の装置。
- 前記バルーン内の前記処置ウィンドウが、円筒形状である、請求項10に記載の装置。
- 前記円筒形状処置ウィンドウが、膨張したとき、長さ約3mm〜約200mmであり、直径約1mm〜100mmである、請求項12に記載の装置。
- 前記反射コーティングが、TiO2、アルミニウム、銀および金からなる群より選択される、請求項10に記載の装置。
- 前記バルーンが、高密度ポリウレタンにより形成されている、請求項10に記載の装置。
- 前記処置ウィンドウが透明である、請求項10に記載の装置。
- 前記処置ウィンドウが半透明である、請求項10に記載の装置。
- 前記バルーンの壁に取り付けられた1以上の光学センサをさらに含む、請求項10に記載の装置。
- 規定された領域に照射を供給する、規定された処置ウィンドウを含む、改良されたバルーンカテーテル装置であって、該改良が、該処置ウィンドウを規定するために該装置の該バルーンの両端に反射材料を用いることを含み、このことによって、処置領域における光の分配の効率および均一性を向上する、装置。
- レーザー光源として、約1.5W未満のレーザーダイオードが用いられる、請求項10に記載の装置。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/649,439 US6013053A (en) | 1996-05-17 | 1996-05-17 | Balloon catheter for photodynamic therapy |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54130797A Division JP3618358B2 (ja) | 1996-05-17 | 1997-05-16 | 光力学治療のためのバルーンカテーテル |
Publications (2)
Publication Number | Publication Date |
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JP2005046640A true JP2005046640A (ja) | 2005-02-24 |
JP4122323B2 JP4122323B2 (ja) | 2008-07-23 |
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Application Number | Title | Priority Date | Filing Date |
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JP54130797A Expired - Lifetime JP3618358B2 (ja) | 1996-05-17 | 1997-05-16 | 光力学治療のためのバルーンカテーテル |
JP2004267607A Expired - Lifetime JP4122323B2 (ja) | 1996-05-17 | 2004-09-14 | 光力学治療のためのバルーンカテーテル |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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JP54130797A Expired - Lifetime JP3618358B2 (ja) | 1996-05-17 | 1997-05-16 | 光力学治療のためのバルーンカテーテル |
Country Status (18)
Country | Link |
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US (2) | US6013053A (ja) |
EP (2) | EP1563871B1 (ja) |
JP (2) | JP3618358B2 (ja) |
KR (1) | KR20000011161A (ja) |
CN (1) | CN1154444C (ja) |
AR (1) | AR007092A1 (ja) |
AT (2) | ATE299673T1 (ja) |
AU (1) | AU720161B2 (ja) |
CA (1) | CA2255058C (ja) |
CZ (1) | CZ370798A3 (ja) |
DE (2) | DE69733754T2 (ja) |
ES (1) | ES2293407T3 (ja) |
HK (1) | HK1019548A1 (ja) |
NO (1) | NO985331L (ja) |
NZ (1) | NZ332863A (ja) |
PL (1) | PL329947A1 (ja) |
TW (1) | TW368419B (ja) |
WO (1) | WO1997043965A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2023181811A1 (ja) * | 2022-03-23 | 2023-09-28 | テルモ株式会社 | 医療デバイス |
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JP4122323B2 (ja) | 2008-07-23 |
NO985331L (no) | 1999-01-18 |
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JP2001505443A (ja) | 2001-04-24 |
CZ370798A3 (cs) | 1999-06-16 |
NO985331D0 (no) | 1998-11-16 |
CA2255058A1 (en) | 1997-11-27 |
ATE299673T1 (de) | 2005-08-15 |
EP1563871A1 (en) | 2005-08-17 |
AU2759797A (en) | 1997-12-09 |
ES2293407T3 (es) | 2008-03-16 |
CN1222841A (zh) | 1999-07-14 |
DE69733754T2 (de) | 2006-04-27 |
JP3618358B2 (ja) | 2005-02-09 |
CA2255058C (en) | 2004-06-29 |
CN1154444C (zh) | 2004-06-23 |
DE69733754D1 (en) | 2005-08-25 |
EP0902653B1 (en) | 2005-07-20 |
AR007092A1 (es) | 1999-10-13 |
DE69738119D1 (de) | 2007-10-18 |
PL329947A1 (en) | 1999-04-26 |
EP1563871B1 (en) | 2007-09-05 |
TW368419B (en) | 1999-09-01 |
WO1997043965A1 (en) | 1997-11-27 |
HK1019548A1 (en) | 2000-02-18 |
ATE372147T1 (de) | 2007-09-15 |
DE69738119T2 (de) | 2008-05-29 |
US6013053A (en) | 2000-01-11 |
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