JP2005046146A5 - - Google Patents
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- Publication number
- JP2005046146A5 JP2005046146A5 JP2004212340A JP2004212340A JP2005046146A5 JP 2005046146 A5 JP2005046146 A5 JP 2005046146A5 JP 2004212340 A JP2004212340 A JP 2004212340A JP 2004212340 A JP2004212340 A JP 2004212340A JP 2005046146 A5 JP2005046146 A5 JP 2005046146A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- nucleic acid
- cell
- antibody
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 41
- 229920001184 polypeptide Polymers 0.000 claims 40
- 102000004196 processed proteins & peptides Human genes 0.000 claims 40
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 29
- 102000039446 nucleic acids Human genes 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 23
- 239000013598 vector Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 210000001043 capillary endothelial cell Anatomy 0.000 claims 8
- 230000035755 proliferation Effects 0.000 claims 8
- 230000001177 retroviral effect Effects 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 230000001780 adrenocortical effect Effects 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 3
- 101710172711 Structural protein Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 230000001919 adrenal effect Effects 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 230000001054 cortical effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000018448 secretion by cell Effects 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 210000004404 adrenal cortex Anatomy 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
Applications Claiming Priority (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/025108 WO1999028462A2 (en) | 1997-12-03 | 1998-12-01 | Polypeptides and nucleic acids encoding the same |
| US11285098P | 1998-12-16 | 1998-12-16 | |
| US11555499P | 1999-01-12 | 1999-01-12 | |
| PCT/US1999/005028 WO1999046281A2 (en) | 1998-03-10 | 1999-03-08 | Novel polypeptides and nucleic acids encoding the same |
| US12395799P | 1999-03-12 | 1999-03-12 | |
| US13144599P | 1999-04-28 | 1999-04-28 | |
| US13428799P | 1999-05-14 | 1999-05-14 | |
| PCT/US1999/012252 WO1999063088A2 (en) | 1998-06-02 | 1999-06-02 | Membrane-bound proteins and nucleic acids encoding the same |
| US14103799P | 1999-06-23 | 1999-06-23 | |
| US14475899P | 1999-07-20 | 1999-07-20 | |
| US14569899P | 1999-07-26 | 1999-07-26 | |
| PCT/US1999/020111 WO2000012708A2 (en) | 1998-09-01 | 1999-09-01 | Further pro polypeptides and sequences thereof |
| PCT/US1999/020594 WO2000015666A2 (en) | 1998-09-10 | 1999-09-08 | Compositions and methods for the treatment of tumors |
| PCT/US1999/020944 WO2000015792A2 (en) | 1998-09-14 | 1999-09-13 | Promotion or inhibition of angiogenesis and cardiovascularization |
| PCT/US1999/021547 WO2000015797A2 (en) | 1998-09-17 | 1999-09-15 | Compositions and methods for the treatment of immune related diseases |
| PCT/US1999/021090 WO2000015796A2 (en) | 1998-09-16 | 1999-09-15 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US1999/023089 WO2000021996A2 (en) | 1998-10-13 | 1999-10-05 | Methods and compositions for inhibiting neoplastic cell growth |
| US16250699P | 1999-10-29 | 1999-10-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584912A Division JP3695642B2 (ja) | 1998-12-01 | 1999-11-30 | 血管形成及び心臓血管新生の促進又は阻害 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005180188A Division JP4358159B2 (ja) | 1998-12-01 | 2005-06-21 | 血管形成及び心臓血管新生の促進又は阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005046146A JP2005046146A (ja) | 2005-02-24 |
| JP2005046146A5 true JP2005046146A5 (OSRAM) | 2005-09-22 |
| JP3803681B2 JP3803681B2 (ja) | 2006-08-02 |
Family
ID=37398593
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584912A Expired - Fee Related JP3695642B2 (ja) | 1998-12-01 | 1999-11-30 | 血管形成及び心臓血管新生の促進又は阻害 |
| JP2004212340A Expired - Lifetime JP3803681B2 (ja) | 1998-12-01 | 2004-07-20 | 血管形成及び心臓血管新生の促進又は阻害 |
| JP2005180188A Expired - Lifetime JP4358159B2 (ja) | 1998-12-01 | 2005-06-21 | 血管形成及び心臓血管新生の促進又は阻害 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584912A Expired - Fee Related JP3695642B2 (ja) | 1998-12-01 | 1999-11-30 | 血管形成及び心臓血管新生の促進又は阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005180188A Expired - Lifetime JP4358159B2 (ja) | 1998-12-01 | 2005-06-21 | 血管形成及び心臓血管新生の促進又は阻害 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1135485B1 (OSRAM) |
| JP (3) | JP3695642B2 (OSRAM) |
| KR (1) | KR100529270B1 (OSRAM) |
| AT (1) | ATE458050T1 (OSRAM) |
| AU (1) | AU771751C (OSRAM) |
| CA (1) | CA2347835A1 (OSRAM) |
| IL (1) | IL202176A0 (OSRAM) |
| MX (1) | MXPA01005169A (OSRAM) |
| WO (1) | WO2000032221A2 (OSRAM) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000053757A2 (en) * | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
| WO2000053760A2 (en) * | 1999-03-12 | 2000-09-14 | Genentech, Inc. | Method of preventing the death of retinal neurons and treating ocular diseases |
| US7285267B2 (en) | 1997-01-14 | 2007-10-23 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6α & 6β |
| EP1007659B1 (en) | 1997-01-14 | 2007-06-27 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6 alpha & 6 beta |
| WO1999066041A1 (en) | 1998-06-16 | 1999-12-23 | Human Genome Sciences, Inc. | 94 human secreted proteins |
| US20030068623A1 (en) * | 1997-06-16 | 2003-04-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PT1015587E (pt) | 1997-09-18 | 2008-07-31 | Genentech Inc | Polipéptido dcr3, um homólogo de tnfr |
| US6503184B1 (en) | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US6689607B2 (en) | 1997-10-21 | 2004-02-10 | Human Genome Sciences, Inc. | Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| IL138488A0 (en) | 1998-03-17 | 2001-10-31 | Genentech Inc | Polypeptides homologous to vegf and bmp1 |
| US6949339B1 (en) | 1998-05-21 | 2005-09-27 | Diadexus, Inc. | Method of diagnosing, monitoring, and staging colon cancer |
| US7014996B1 (en) | 1998-10-02 | 2006-03-21 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers |
| ES2279647T3 (es) | 1998-11-10 | 2007-08-16 | Emory University | Reguladores mitogenicos. |
| US6432673B1 (en) | 1998-12-07 | 2002-08-13 | Zymogenetics, Inc. | Growth factor homolog ZVEGF3 |
| EP1143005A4 (en) * | 1998-12-09 | 2002-11-06 | Shionogi & Co | PHOSPHOLIPASE A 2? HUMAN SECRETORY |
| AU2486300A (en) * | 1998-12-30 | 2000-07-31 | Millennium Pharmaceuticals, Inc. | Secreted proteins and nucleic acids encoding them |
| WO2000053776A2 (en) * | 1999-03-11 | 2000-09-14 | Mount Sinai Hospital | Human kallikrein-like genes |
| WO2001003720A2 (en) * | 1999-07-12 | 2001-01-18 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs |
| EP1198568B1 (en) * | 1999-07-20 | 2007-07-25 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| AU3902600A (en) * | 1999-09-15 | 2001-04-17 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
| EP1239050A4 (en) * | 1999-12-09 | 2004-07-21 | Sankyo Co | METHOD FOR TESTING CURATIVE OR PREVENTIVE AGENT OF HYPERLIPEMIA |
| US7119165B2 (en) | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
| DE60142023D1 (de) * | 2000-01-12 | 2010-06-17 | Univ Yale | Nogo rezeptor-vermittelte blockade des axonalen wachstums |
| AU2001245371A1 (en) * | 2000-02-28 | 2001-09-12 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding |
| CN1633498A (zh) | 2000-04-21 | 2005-06-29 | 武田药品工业株式会社 | 新型胰岛素/胰岛素样生长因子/松弛素家族多肽及其dna |
| AU2001271973A1 (en) * | 2000-07-20 | 2002-02-05 | Kevin P. Baker | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| NZ525422A (en) | 2000-10-06 | 2006-09-29 | Biogen Idec Inc | Isolated polynucleotides comprising a nucleic acid which encodes a polypeptide which modulates axonal growth in CNS neurons |
| US20020111302A1 (en) * | 2000-11-30 | 2002-08-15 | Y. Tom Tang | Novel nucleic acids and polypeptides |
| JPWO2002057448A1 (ja) * | 2000-12-27 | 2004-05-20 | 第一ファインケミカル株式会社 | 新規ペプチド及びその活性 |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| WO2003006687A2 (en) * | 2001-07-10 | 2003-01-23 | Medigene Ag | Novel target genes for diseases of the heart |
| JP2005513084A (ja) * | 2001-12-19 | 2005-05-12 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物及び方法 |
| US7314866B2 (en) * | 2002-03-01 | 2008-01-01 | Bloodcenter Of Wisconsin, Inc. | Ku-70-derived Bax-suppressing peptides and use thereof for the protection of damaged cells |
| WO2003083114A1 (fr) * | 2002-03-28 | 2003-10-09 | Yamanouchi Pharmaceutical Co., Ltd. | Facteur de croissance associe a une antiopoietine |
| WO2004002515A1 (ja) * | 2002-06-28 | 2004-01-08 | Takeda Chemical Industries, Ltd. | 呼吸器疾患の診断・予防・治療剤 |
| PT1534736E (pt) | 2002-08-10 | 2010-09-07 | Univ Yale | Antagonistas do receptor nogo |
| WO2005068497A1 (en) * | 2004-01-06 | 2005-07-28 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Iis: a novel ifn-gamma-inducible protein, member of the secretoglobin family, that modulates cellular invasion and migration |
| WO2007008732A2 (en) | 2005-07-07 | 2007-01-18 | Yale University | Compositions and methods for suppressing axonal growth inhibition |
| AU2015271709B2 (en) | 2014-06-06 | 2020-11-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| CA2988115A1 (en) | 2015-06-03 | 2016-12-08 | Bristol-Myers Squibb Company | Anti-gitr antibodies for cancer diagnostics |
| JP6983776B2 (ja) | 2015-11-19 | 2021-12-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | グルココルチコイド誘発腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| KR20200006115A (ko) | 2017-05-16 | 2020-01-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-gitr 효능제 항체에 의한 암의 치료 |
| CN109136275B (zh) * | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化gitr基因改造动物模型的制备方法及应用 |
| CN114507677B (zh) * | 2022-02-16 | 2023-09-05 | 中国人民解放军空军军医大学 | Ndufs1基因在治疗心梗后心衰中的应用和相关产品 |
| EP4484444A1 (en) * | 2023-06-28 | 2025-01-01 | Centre National de la Recherche Scientifique | Protein and fragments thereof, and their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900673A (en) * | 1988-03-28 | 1990-02-13 | President And Fellows Of Harvard College | Mutant human angiogenin (angiogenesis factor with superior angiogenin activity) genes therefor and methods of expression |
| EP0646178A1 (en) | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | expression cassette with regularoty regions functional in the mammmlian host |
| CN1636594B (zh) * | 1994-04-26 | 2012-08-29 | 儿童医学中心公司 | 血管生成抑制素和用于抑制血管生成的方法 |
| US5681746A (en) | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
-
1999
- 1999-11-30 CA CA002347835A patent/CA2347835A1/en not_active Abandoned
- 1999-11-30 WO PCT/US1999/028313 patent/WO2000032221A2/en not_active Ceased
- 1999-11-30 MX MXPA01005169A patent/MXPA01005169A/es not_active Application Discontinuation
- 1999-11-30 AU AU17482/00A patent/AU771751C/en not_active Expired
- 1999-11-30 AT AT99960624T patent/ATE458050T1/de not_active IP Right Cessation
- 1999-11-30 KR KR10-2001-7006818A patent/KR100529270B1/ko not_active Expired - Lifetime
- 1999-11-30 JP JP2000584912A patent/JP3695642B2/ja not_active Expired - Fee Related
- 1999-11-30 EP EP99960624A patent/EP1135485B1/en not_active Expired - Lifetime
-
2004
- 2004-07-20 JP JP2004212340A patent/JP3803681B2/ja not_active Expired - Lifetime
-
2005
- 2005-06-21 JP JP2005180188A patent/JP4358159B2/ja not_active Expired - Lifetime
-
2009
- 2009-11-17 IL IL202176A patent/IL202176A0/en unknown
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