JP2005035930A - Antifungal agent and antimicrobial product using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a new antifungal agent useful for various uses for controlling reproduction of a dandruff causative being an indigenous fungus in the skin, especially an antifungal agent suitable for a safe hair cosmetic, having prevention effect on dandruff development. <P>SOLUTION: The antifungal agent comprises lilac aldehyde represented by formula as an active ingredient. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an antifungal agent used for the purpose of suppressing the growth of skin resident fungi, and to a cosmetic for hair containing the antifungal agent.

  The scalp is inhabited with normal skin bacteria that exist in normal skin, such as Acne gonorrhoeae that causes acne. Similarly, a lipid-requiring fungus, Malassezia furfur, is a skin resident fungus. The occurrence of dandruff is largely related to the lipid-requiring skin resident fungi, which is a perfect condition for the growth of the scalp with a large amount of sebaceous glands and a large amount of sebum. Dandruff is a substance that has been exfoliated due to metabolism, and is physiologically generated by anyone. However, when the amount of dandruff is abnormally high, it is called dandruff. If left untreated, it may be itchy, it may be scratched with nails, and the scalp may be inflamed. In addition, dandruff has dryness and wetness, and in general, many dandruffs are considered to have high wetness due to excessive secretion of sebum. Many of them are considered to be a leading or mild type of seborrheic dermatitis and are said to occur more frequently in men than in women. Thus, it is known that a dandruff-causing bacterium, Malassezia furfur, grows and increases in activity on the scalp with a lot of sebum, thereby deteriorating dandruff and itching. Furthermore, the occurrence of dandruff is also known as a cause of hair loss.

  Conventionally, it is effective to wash the hair with a shampoo containing antibacterial and bacteriostatic zinc pyrithione, octopirox, piroctone olamine, etc. as a countermeasure. However, zinc pyrithione has been reported by the National Institute for Environmental Studies as being suspected of being an environmental hormone, and future trends are drawing attention.

  In order to solve the above problems, several antibacterial agents using natural extracts have been proposed. For example, in Patent Document 1, an antibacterial composition containing a ginkgo endoderm extract as an active ingredient is included, and in Patent Document 2, one or more of the Orchidaceae genus Ebine or Ganzekilan is included as an active ingredient. According to Patent Document 3, the anti-dandruff effect, the blood circulation promoting effect, the antipruritic effect, and the hair growth effect on the scalp are obtained by ashing seaweed raw materials, for example, brown algae such as seaweed, kombu and honda walla. Anti-dandruff agent containing seaweed ash or extract thereof as an active ingredient, and further, in Patent Document 4, a coumarin analog mixture obtained from the peel of citrus fruit, particularly a coumarin analog mixture obtained from citrus cold press oil An antibacterial agent containing as an active ingredient has been proposed.

  However, such naturally-derived antibacterial agents have problems such as an unfavorable effect on the scent of the target to be added. Moreover, no mention is made of antibacterial properties against skin resident fungi of fragrance compounds that give a pleasant scent to hair-washing cosmetics, hair-growing agents, hair-finishing cosmetic agents, permanent wave agents, hair dyes and hair bleaches.

On the other hand, some of the known perfume compounds have been reported to exhibit antibacterial activity against specific bacteria, but the antifungal activity of lilac aldehyde against Malassezia furfur, a skin resident fungus, has been reported. I don't see any suggestions about sex.
Japanese Patent Laid-Open No. 10-27316 Japanese Patent Laid-Open No. 11-279033 JP 2000-344678 A JP 2002-275007 A

  From the above situation, it has been desired to develop a safe antifungal agent having an effect of preventing dandruff.

  An object of the present invention is to provide an antifungal agent that can be used in various applications for suppressing the growth of dandruff-causing bacteria that are skin-resident fungi, and in particular, an antifungal agent suitable for safe hair cosmetics that is effective in preventing dandruff. Is to provide.

  Another object of the present invention is to provide a cosmetic for hair having a pleasant fragrance containing the antifungal agent.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that among the fragrance compounds, lilac aldehyde exhibits a strong antifungal activity against skin resident fungi, and have reached the present invention. That is, the present invention achieves the above-mentioned object, and the antifungal agent of the present invention has the ability to inhibit proliferation specifically against the dandruff-causing fungus, Malassezia furfur, represented by the following formula (1) )

で示されるライラックアルデヒドを有効成分として含むことを特徴とする抗真菌剤の提供によって達成される。

It is achieved by providing an antifungal agent characterized by comprising a lilac aldehyde represented by the formula:

  Furthermore, the other aspect of this invention is the cosmetics for hair formed by mix | blending the said antifungal agent, the preventive agent or therapeutic agent of a dandruff.

  According to the present invention, lilac aldehyde has an excellent antifungal action and has the effect of preventing or treating dandruff by suppressing the growth of Malassezia furfur, which causes dandruff. It is done. Addition of these compounds to hair cosmetics can suppress dandruff and itch caused by dandruff.

  The present invention has the following formula

で示されるライラックアルデヒドを有効成分として含む抗真菌剤は、皮膚常在真菌である、マラセチア属フルフル（Ｍａｌａｓｓｅｚｉａ ｆｕｒｆｕｒ）に対して強い抗真菌性を示し、この真菌の増殖を抑制することによりふけの発生を抑えるものである。しかも、本発明で用いられる選択された前記式で示されるライラックアルデヒドは、ふけの発生を抑えることから、抜け毛予防も期待できる。

The antifungal agent containing lilacaldehyde as an active ingredient is a strong antifungal property against malassezia furfur, a skin resident fungus, and suppresses the growth of this fungus by inhibiting the growth of this fungus. It suppresses the occurrence. Moreover, the lilac aldehyde represented by the selected formula used in the present invention suppresses the occurrence of dandruff, and therefore can be expected to prevent hair loss.

  The production method of the lilac aldehyde of the present invention has been established, and can be synthesized according to a known method such as the method described in JP-A No. 2000-336083.

  The antifungal agent of the present invention is preferably used in cosmetics for hair because it acts on skin resident fungi and exhibits the ability to suppress the growth of dandruff-causing fungi.

  Cosmetics for hair in the present invention include shampoos, rinses, conditioners, rinse-in shampoos, hair-washing cosmetics such as treatments, hair foams, hair mousses, hair sprays, hair mists, hair gels, water greases, set lotions, color lotions, hair liquids, pomades. Hair finishes such as tics, hair creams, hair blows, split coats, hair oils, hair tonics, color sticks, color sprays, liquid types, gel types, oxidative hair dyes, hair restorers, permanent waves Preparations and hair bleaches.

  The blending amount of the antifungal agent of the present invention in these cosmetics for hair may vary depending on the type of product, the purpose of use, etc., but is preferably 0.01 to 5% by mass, more preferably 0, based on the total amount. 0.025 to 1% by mass.

  Further, the antifungal agent of the present invention is an active ingredient such as other antibacterial agents, bactericides, anti-inflammatory analgesics, surfactants, thickeners, pigments, fragrances, alcohols, etc., as long as the effects of the present invention are not impaired. It can be used in combination with auxiliary ingredients.

  Next, the present invention will be described based on test examples and examples.

(Test Example 1)
The antifungal test was conducted using the following (a) fragrance compound, (b) one strain and (c) one medium.
(A) Perfume compound: Lilac aldehyde (b) Bacterial strain used:
Malassezia fluflu NBRC 0656 (Malassezia furfur)
(C) Medium used:
Biological Genetic Resource Center (NBRC) Restoration Culture Medium 103

In a 500 ml Erlenmeyer flask, put 100 ml of the above medium, inoculate the cell suspension to 10 ⁵ CFU / ml, and add the fragrance compound to the concentration shown in Table 1, After opening the silicon vent plug, after performing reciprocal shaking culture at 80 ° C. for 48 hours at 80 ° C., the turbidity (absorbance at 660 nm) of the culture solution was measured. As a result, as shown in Table 1, a strong growth inhibitory effect was recognized.

Transparent shampoo 1). Laurylpolyethylene (3) Sulfate sodium salt (30% aqueous solution) 30.0 (mass%)
2). Lauryl sulfate sodium salt (30% aqueous solution) 10.0
3). Palm oil fatty acid diethanolamide 4.0
4). Glycerin 1.0
5). Lilac aldehyde 0.025
6). Fragrance 0.375
7). Dye 0.01
8). Metal ion sequestering agent, pH adjuster 0.01
9). Purified water 54.58
Production method: (1) to (8) are sequentially added to (9) and uniformly mixed and dissolved.

Rinse 1). Silicone oil 3.0 (mass%)
2). Liquid paraffin 1.0
3). Cetyl alcohol 1.5
4). Stearyl alcohol 1.0
5). Stearyltrimethylammonium chloride 0.7
6). Glycerin 3.0
7). Lilac aldehyde 0.025
8). Fragrance 0.375
9). Dye 0.01
10). Purified water 89.39
Production method: (1) to (9) are sequentially added to (10) and uniformly mixed and dissolved.

  A formulation containing no lilac aldehyde in the formulations of Example 1 and Example 2 was prepared as Comparative Example 1 and Comparative Example 2.

Antidandruff evaluation and itching suppression evaluation Using Example (1 + 2) and Comparative Example (1 + 2), 10 adult boys with dandruff and itch associated with dandruff are usually used for 1 month every morning. We had you use instead of shampoo and rinse and performed dandruff control and itching control test. The evaluation criteria are as shown below, and the number of people who answered each evaluation is shown in Table 2.

Antidandruff and itching effect Effective: Suppressed, Slightly effective: Slightly suppressed, Invalid: No effect

  As shown in Table 2, as a result of the anti-dandruff evaluation, 80% of the panelists answered “effective” in the example (1 + 2) of this experiment, and as a result of the itching suppression evaluation, “effective” in the example (1 + 2) of this experiment. The panel respondents replied “80%, showing suppression of dandruff and improvement of itching, and a very good result was obtained even when compared with the comparative example (1 + 2).

    The antifungal agent of the present invention is preferably used in cosmetics for hair because it acts on skin resident fungi and exhibits the ability to suppress the growth of dandruff-causing fungi.

Claims (2)

Following formula

The antifungal agent characterized by including the lilac aldehyde shown by this as an active ingredient. A cosmetic for hair comprising the antifungal agent according to claim 1.