JP2004537289A5 - - Google Patents

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Publication number
JP2004537289A5
JP2004537289A5 JP2002588919A JP2002588919A JP2004537289A5 JP 2004537289 A5 JP2004537289 A5 JP 2004537289A5 JP 2002588919 A JP2002588919 A JP 2002588919A JP 2002588919 A JP2002588919 A JP 2002588919A JP 2004537289 A5 JP2004537289 A5 JP 2004537289A5
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JP
Japan
Prior art keywords
nucleic acid
cell
hbm
antibody
lrp6
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002588919A
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English (en)
Japanese (ja)
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JP2004537289A (ja
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Publication date
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Priority claimed from PCT/US2002/014877 external-priority patent/WO2002092000A2/en
Publication of JP2004537289A publication Critical patent/JP2004537289A/ja
Publication of JP2004537289A5 publication Critical patent/JP2004537289A5/ja
Withdrawn legal-status Critical Current

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JP2002588919A 2001-05-11 2002-05-13 骨量および脂質レベルを調整するｈｂｍ変異型 Withdrawn JP2004537289A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29007101P 2001-05-11 2001-05-11
US29131101P 2001-05-17 2001-05-17
US35305802P 2002-02-01 2002-02-01
US36129302P 2002-03-04 2002-03-04
PCT/US2002/014877 WO2002092000A2 (en) 2001-05-11 2002-05-13 Hbm variants that modulate bone mass and lipid levels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010146427A Division JP2011004744A (ja) 2001-05-11 2010-06-28 骨量および脂質レベルを調整するｈｂｍ変異型

Publications (2)

Publication Number Publication Date
JP2004537289A JP2004537289A (ja) 2004-12-16
JP2004537289A5 true JP2004537289A5 (enExample) 2005-12-22

Family

ID=27501520

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002589632A Withdrawn JP2005511002A (ja) 2001-05-11 2002-05-13 骨量変調のトランスジェニック動物モデル
JP2002588919A Withdrawn JP2004537289A (ja) 2001-05-11 2002-05-13 骨量および脂質レベルを調整するｈｂｍ変異型
JP2010146427A Pending JP2011004744A (ja) 2001-05-11 2010-06-28 骨量および脂質レベルを調整するｈｂｍ変異型

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2002589632A Withdrawn JP2005511002A (ja) 2001-05-11 2002-05-13 骨量変調のトランスジェニック動物モデル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010146427A Pending JP2011004744A (ja) 2001-05-11 2010-06-28 骨量および脂質レベルを調整するｈｂｍ変異型

Country Status (7)

Country Link
US (2) US7416849B2 (enExample)
EP (2) EP1401269A4 (enExample)
JP (3) JP2005511002A (enExample)
AU (2) AU2002308681A1 (enExample)
BR (2) BR0209563A (enExample)
CA (2) CA2446821A1 (enExample)
WO (2) WO2002092000A2 (enExample)

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IL152654A0 (en) * 2000-05-26 2003-06-24 Genome Therapeutics Corp Regulating lipid levels via the zmaxi or hbm gene
US7514594B2 (en) 2001-05-11 2009-04-07 Wyeth Transgenic animal model of bone mass modulation
BR0209563A (pt) 2001-05-11 2004-12-07 Genome Theraupeutics Corp ácido nucleico, polipeptìdeo, vetor, célula, anticorpo, métodos de diagnosticar um fenótipo e um paciente como expressando um ácido nucleico e de identificar agentes que modulam a atividade de um ácido nucleico e de uma proteìna e lrp5, lrp6, ou hbm e compostos que modulam a interação de dkk com o caminho de sinalização wnt, composição para modular a massa óssea e/ou os nìveis de lipìdeo em um paciente, animal transgênico, embrião e modelo de animal, e, agente
CA2446582A1 (en) * 2001-05-17 2002-11-21 Genome Therapeutics Corporation Reagents and methods for modulating dkk-mediated interactions
US20040038860A1 (en) 2002-05-17 2004-02-26 Allen Kristina M. Reagents and methods for modulating dkk-mediated interactions
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US7223393B2 (en) 2003-02-07 2007-05-29 Pdl Biopharma, Inc Amphiregulin antibodies and their use to treat cancer and psoriasis
FR2856410B1 (fr) * 2003-06-20 2007-06-15 Integragen Sa Methodes de preparation de puces genetiques et utilisations
US20080227734A1 (en) * 2003-11-24 2008-09-18 Gunnar Westin Mutant Lrp5/6 Wnt-Signaling Receptors in Cancer Diagnosis, Prognosis, and Treatment
EP1747462A2 (en) * 2004-04-27 2007-01-31 Galapagos N.V. Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
CA2566256C (en) * 2004-05-07 2015-07-07 Applera Corporation Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
JP2008507294A (ja) 2004-07-26 2008-03-13 ダウ グローバル テクノロジーズ インコーポレイティド 菌株遺伝子操作による改善されたタンパク質発現のための方法
ES2414460T3 (es) 2004-08-04 2013-07-19 Amgen Inc. Anticuerpos para Dkk-1
US7771937B2 (en) * 2005-05-20 2010-08-10 University Of Washington Methods for predicting late onset Alzheimer disease in an individual
US20080293053A1 (en) * 2006-12-28 2008-11-27 The Regents Of The University Of Michigan shRNA Materials and Methods of Using Same for Inhibition of DKK-1
FI3345607T3 (fi) 2006-12-29 2022-11-30 Menetelmiä luun kasvun muuttamiseksi antamalla SOST- tai WISE-antagonistia tai antagonistia
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (en) 2007-04-27 2013-07-17 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
ES2560532T3 (es) * 2007-11-02 2016-02-19 Novartis Ag Moléculas y métodos de modulación de la proteína 6 relacionada con el receptor de lipoproteína de baja densidad (LRP6)
US8716243B2 (en) * 2008-05-28 2014-05-06 St. Jude Childen's Research Hospital Methods of effecting Wnt signaling through Dkk structural analysis
WO2009146956A1 (en) * 2008-06-03 2009-12-10 Universite De Liege Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof
BR112012020257A8 (pt) * 2010-02-11 2018-02-14 Recombinetics Inc métodos e aparelhos para produzir artiodátilos transgênicos
SG184033A1 (en) 2010-03-24 2012-10-30 Genentech Inc Anti-lrp6 antibodies
ES2659406T3 (es) 2010-05-06 2018-03-15 Novartis Ag Composiciones y procedimientos de uso para anticuerpos terapéuticos contra la proteína 6 relacionada con las lipoproteínas de baja densidad (LRP6)
US9290573B2 (en) 2010-05-06 2016-03-22 Novartis Ag Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
MX2014005411A (es) 2011-11-04 2015-02-12 Novartis Ag Construcciones prolongadas de la vida media de la proteina relacionada con lipoproteina de baja densidad 6 (lrp6).
CN104540382A (zh) * 2012-06-12 2015-04-22 弗·哈夫曼-拉罗切有限公司 用于产生条件性敲除等位基因的方法和组合物
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US9932588B2 (en) 2013-11-15 2018-04-03 Northwestern University Inhibition of oxidative stress in atrial fibrillation
US9732345B2 (en) 2013-12-09 2017-08-15 Baylor College Of Medicine Hippo and dystrophin complex signaling in cardiomyocyte renewal
TW201710503A (zh) 2015-06-12 2017-03-16 長庚醫療財團法人林口長庚紀念醫院 新穎多核苷酸、載體、醫藥組成物以及其用途
US20180037909A1 (en) 2016-08-04 2018-02-08 Chang Gung Memorial Hospital, Linkou Modified cancer cell lines and uses thereof
US20190218306A1 (en) * 2018-01-18 2019-07-18 Nalini M. Rajamannan Method of inhibiting ectopic calcification

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IL152654A0 (en) 2000-05-26 2003-06-24 Genome Therapeutics Corp Regulating lipid levels via the zmaxi or hbm gene
JP2004517605A (ja) * 2000-06-21 2004-06-17 デルタジェン　インコーポレイテッド 標的化遺伝子破壊を含むトランスジェニックマウス
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