JP2005511002A - 骨量変調のトランスジェニック動物モデル - Google Patents
骨量変調のトランスジェニック動物モデル Download PDFInfo
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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- G01N2333/475—Assays involving growth factors
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| US6770461B1 (en) | 1998-10-23 | 2004-08-03 | Genome Therapeutics Corporation | High bone mass gene of 11q13.3 |
| IL152654A0 (en) * | 2000-05-26 | 2003-06-24 | Genome Therapeutics Corp | Regulating lipid levels via the zmaxi or hbm gene |
| US7514594B2 (en) | 2001-05-11 | 2009-04-07 | Wyeth | Transgenic animal model of bone mass modulation |
| BR0209563A (pt) | 2001-05-11 | 2004-12-07 | Genome Theraupeutics Corp | ácido nucleico, polipeptìdeo, vetor, célula, anticorpo, métodos de diagnosticar um fenótipo e um paciente como expressando um ácido nucleico e de identificar agentes que modulam a atividade de um ácido nucleico e de uma proteìna e lrp5, lrp6, ou hbm e compostos que modulam a interação de dkk com o caminho de sinalização wnt, composição para modular a massa óssea e/ou os nìveis de lipìdeo em um paciente, animal transgênico, embrião e modelo de animal, e, agente |
| CA2446582A1 (en) * | 2001-05-17 | 2002-11-21 | Genome Therapeutics Corporation | Reagents and methods for modulating dkk-mediated interactions |
| US20040038860A1 (en) | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| US7223393B2 (en) | 2003-02-07 | 2007-05-29 | Pdl Biopharma, Inc | Amphiregulin antibodies and their use to treat cancer and psoriasis |
| FR2856410B1 (fr) * | 2003-06-20 | 2007-06-15 | Integragen Sa | Methodes de preparation de puces genetiques et utilisations |
| US20080227734A1 (en) * | 2003-11-24 | 2008-09-18 | Gunnar Westin | Mutant Lrp5/6 Wnt-Signaling Receptors in Cancer Diagnosis, Prognosis, and Treatment |
| EP1747462A2 (en) * | 2004-04-27 | 2007-01-31 | Galapagos N.V. | Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts |
| CA2566256C (en) * | 2004-05-07 | 2015-07-07 | Applera Corporation | Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof |
| JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
| ES2414460T3 (es) | 2004-08-04 | 2013-07-19 | Amgen Inc. | Anticuerpos para Dkk-1 |
| US7771937B2 (en) * | 2005-05-20 | 2010-08-10 | University Of Washington | Methods for predicting late onset Alzheimer disease in an individual |
| US20080293053A1 (en) * | 2006-12-28 | 2008-11-27 | The Regents Of The University Of Michigan | shRNA Materials and Methods of Using Same for Inhibition of DKK-1 |
| FI3345607T3 (fi) | 2006-12-29 | 2022-11-30 | Menetelmiä luun kasvun muuttamiseksi antamalla SOST- tai WISE-antagonistia tai antagonistia | |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| EP2615172A1 (en) | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| ES2560532T3 (es) * | 2007-11-02 | 2016-02-19 | Novartis Ag | Moléculas y métodos de modulación de la proteína 6 relacionada con el receptor de lipoproteína de baja densidad (LRP6) |
| US8716243B2 (en) * | 2008-05-28 | 2014-05-06 | St. Jude Childen's Research Hospital | Methods of effecting Wnt signaling through Dkk structural analysis |
| WO2009146956A1 (en) * | 2008-06-03 | 2009-12-10 | Universite De Liege | Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof |
| BR112012020257A8 (pt) * | 2010-02-11 | 2018-02-14 | Recombinetics Inc | métodos e aparelhos para produzir artiodátilos transgênicos |
| SG184033A1 (en) | 2010-03-24 | 2012-10-30 | Genentech Inc | Anti-lrp6 antibodies |
| ES2659406T3 (es) | 2010-05-06 | 2018-03-15 | Novartis Ag | Composiciones y procedimientos de uso para anticuerpos terapéuticos contra la proteína 6 relacionada con las lipoproteínas de baja densidad (LRP6) |
| US9290573B2 (en) | 2010-05-06 | 2016-03-22 | Novartis Ag | Therapeutic low density lipoprotein-related protein 6 (LRP6) multivalent antibodies |
| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| MX2014005411A (es) | 2011-11-04 | 2015-02-12 | Novartis Ag | Construcciones prolongadas de la vida media de la proteina relacionada con lipoproteina de baja densidad 6 (lrp6). |
| CN104540382A (zh) * | 2012-06-12 | 2015-04-22 | 弗·哈夫曼-拉罗切有限公司 | 用于产生条件性敲除等位基因的方法和组合物 |
| US8959241B2 (en) * | 2012-07-23 | 2015-02-17 | Adobe Systems Incorporated | Method and apparatus for performing server-side splicing for live streaming media |
| US9932588B2 (en) | 2013-11-15 | 2018-04-03 | Northwestern University | Inhibition of oxidative stress in atrial fibrillation |
| US9732345B2 (en) | 2013-12-09 | 2017-08-15 | Baylor College Of Medicine | Hippo and dystrophin complex signaling in cardiomyocyte renewal |
| TW201710503A (zh) | 2015-06-12 | 2017-03-16 | 長庚醫療財團法人林口長庚紀念醫院 | 新穎多核苷酸、載體、醫藥組成物以及其用途 |
| US20180037909A1 (en) | 2016-08-04 | 2018-02-08 | Chang Gung Memorial Hospital, Linkou | Modified cancer cell lines and uses thereof |
| US20190218306A1 (en) * | 2018-01-18 | 2019-07-18 | Nalini M. Rajamannan | Method of inhibiting ectopic calcification |
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| US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| AU7392696A (en) | 1995-10-04 | 1997-04-28 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins |
| US5691153A (en) * | 1996-09-06 | 1997-11-25 | Creighton University | Genetic markers to detect high bone mass |
| EP0988379B1 (en) * | 1997-04-15 | 2007-04-11 | The Wellcome Trust Limited as Trustee to the Wellcome Trust | Ldl-receptor |
| US6555654B1 (en) * | 1997-04-15 | 2003-04-29 | The Wellcome Trust Limited As Trustee For The Wellcome Trust | LDL-receptor |
| BE1011331A6 (fr) | 1997-08-20 | 1999-07-06 | Univ Catholique De Louvain Hal | Polypeptide associe au peroxysome, sequence nucleotidique encodant ledit polypeptide et leur utilisation dans le diagnostic et/ou le traitement de maladies ou de lesions pulmonaires. |
| EP1064289A1 (en) | 1998-03-18 | 2001-01-03 | Ariad Pharmaceuticals, Inc. | Heterocyclic signal transduction inhibitors, compositions containing them |
| AU4023200A (en) | 1999-03-26 | 2000-10-16 | Human Genome Sciences, Inc. | 50 human secreted proteins |
| IL151904A0 (en) * | 2000-04-05 | 2003-04-10 | Genome Therapeutics Corp | THE HIGH BONE MASS GENE OF 11q13.3 |
| IL152654A0 (en) | 2000-05-26 | 2003-06-24 | Genome Therapeutics Corp | Regulating lipid levels via the zmaxi or hbm gene |
| JP2004517605A (ja) * | 2000-06-21 | 2004-06-17 | デルタジェン インコーポレイテッド | 標的化遺伝子破壊を含むトランスジェニックマウス |
| EP1313753A4 (en) | 2000-08-18 | 2004-09-15 | Proskelia | REGULATORY GENE AND SYSTEM FOR USE IN THE DIAGNOSIS AND TREATMENT OF OSTEOPOROSIS |
| BR0209563A (pt) | 2001-05-11 | 2004-12-07 | Genome Theraupeutics Corp | ácido nucleico, polipeptìdeo, vetor, célula, anticorpo, métodos de diagnosticar um fenótipo e um paciente como expressando um ácido nucleico e de identificar agentes que modulam a atividade de um ácido nucleico e de uma proteìna e lrp5, lrp6, ou hbm e compostos que modulam a interação de dkk com o caminho de sinalização wnt, composição para modular a massa óssea e/ou os nìveis de lipìdeo em um paciente, animal transgênico, embrião e modelo de animal, e, agente |
| US8637506B2 (en) * | 2003-09-22 | 2014-01-28 | Enzo Biochem, Inc. | Compositions and methods for bone formation and remodeling |
| DE102007020878B4 (de) | 2007-05-04 | 2020-06-18 | Dr. Ing. H.C. F. Porsche Aktiengesellschaft | Verfahren zur Prüfung von Umströmungsgeräuschen |
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| BR0209564A (pt) | 2004-10-26 |
| US20050070699A1 (en) | 2005-03-31 |
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| CA2446821A1 (en) | 2002-11-21 |
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| EP1401269A2 (en) | 2004-03-31 |
| AU2002308681A1 (en) | 2002-11-25 |
| EP1483288A2 (en) | 2004-12-08 |
| WO2002092000A3 (en) | 2004-10-07 |
| US20090136507A1 (en) | 2009-05-28 |
| CA2446859A1 (en) | 2002-11-21 |
| EP1401269A4 (en) | 2005-09-28 |
| JP2004537289A (ja) | 2004-12-16 |
| US7416849B2 (en) | 2008-08-26 |
| BR0209563A (pt) | 2004-12-07 |
| EP1483288A4 (en) | 2005-09-21 |
| WO2002092000A2 (en) | 2002-11-21 |
| WO2002092764A3 (en) | 2003-12-24 |
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