JP2004535473A5 - - Google Patents
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- Publication number
- JP2004535473A5 JP2004535473A5 JP2003515226A JP2003515226A JP2004535473A5 JP 2004535473 A5 JP2004535473 A5 JP 2004535473A5 JP 2003515226 A JP2003515226 A JP 2003515226A JP 2003515226 A JP2003515226 A JP 2003515226A JP 2004535473 A5 JP2004535473 A5 JP 2004535473A5
- Authority
- JP
- Japan
- Prior art keywords
- implant
- sustained release
- tablet
- pharmaceutically active
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000013268 sustained release Methods 0.000 claims 44
- 239000012730 sustained-release form Substances 0.000 claims 44
- 239000007943 implant Substances 0.000 claims 43
- 239000008185 minitablet Substances 0.000 claims 26
- 239000003826 tablet Substances 0.000 claims 20
- 239000004480 active ingredient Substances 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 12
- 238000011282 treatment Methods 0.000 claims 10
- 230000000507 anthelmentic effect Effects 0.000 claims 9
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 9
- 230000036765 blood level Effects 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 5
- 108010051696 Growth Hormone Proteins 0.000 claims 4
- 102000018997 Growth Hormone Human genes 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 239000000122 growth hormone Substances 0.000 claims 4
- 150000002596 lactones Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000001737 promoting effect Effects 0.000 claims 4
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000282414 Homo sapiens Species 0.000 claims 3
- -1 antidiabetics Substances 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims 2
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229940035676 analgesics Drugs 0.000 claims 2
- 239000000730 antalgic agent Substances 0.000 claims 2
- 239000000921 anthelmintic agent Substances 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000003096 antiparasitic agent Substances 0.000 claims 2
- 229940125687 antiparasitic agent Drugs 0.000 claims 2
- 230000004323 axial length Effects 0.000 claims 2
- 108010015046 cell aggregation factors Proteins 0.000 claims 2
- 239000007891 compressed tablet Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003630 growth substance Substances 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 2
- 229960002418 ivermectin Drugs 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 239000008188 pellet Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001296 polysiloxane Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000272517 Anseriformes Species 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 1
- 241000282832 Camelidae Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 241000938605 Crocodylia Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241000289419 Metatheria Species 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 241000282339 Mustela Species 0.000 claims 1
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 101000868138 Ovis aries Somatotropin Proteins 0.000 claims 1
- 241000286209 Phasianidae Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229910001514 alkali metal chloride Inorganic materials 0.000 claims 1
- 229940124325 anabolic agent Drugs 0.000 claims 1
- 239000003263 anabolic agent Substances 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 229940069428 antacid Drugs 0.000 claims 1
- 239000003159 antacid agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000001458 anti-acid effect Effects 0.000 claims 1
- 230000001165 anti-coccidial effect Effects 0.000 claims 1
- 230000001773 anti-convulsant effect Effects 0.000 claims 1
- 230000003178 anti-diabetic effect Effects 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229940124346 antiarthritic agent Drugs 0.000 claims 1
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 229960003965 antiepileptics Drugs 0.000 claims 1
- 229940030225 antihemorrhagics Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229960005475 antiinfective agent Drugs 0.000 claims 1
- 239000003904 antiprotozoal agent Substances 0.000 claims 1
- 239000003435 antirheumatic agent Substances 0.000 claims 1
- 239000003699 antiulcer agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 229960000074 biopharmaceutical Drugs 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000003114 blood coagulation factor Substances 0.000 claims 1
- 229940019700 blood coagulation factors Drugs 0.000 claims 1
- 239000003633 blood substitute Substances 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 230000004097 bone metabolism Effects 0.000 claims 1
- 108010006025 bovine growth hormone Proteins 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 239000000168 bronchodilator agent Substances 0.000 claims 1
- 239000003560 cancer drug Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 claims 1
- 239000003576 central nervous system agent Substances 0.000 claims 1
- 235000013330 chicken meat Nutrition 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 229960003964 deoxycholic acid Drugs 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 239000003172 expectorant agent Substances 0.000 claims 1
- 230000003419 expectorant effect Effects 0.000 claims 1
- 229940066493 expectorants Drugs 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 229910021485 fumed silica Inorganic materials 0.000 claims 1
- 239000007952 growth promoter Substances 0.000 claims 1
- 239000002874 hemostatic agent Substances 0.000 claims 1
- 230000002439 hemostatic effect Effects 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 238000002657 hormone replacement therapy Methods 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 229910017053 inorganic salt Inorganic materials 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 229940035363 muscle relaxants Drugs 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 229930014626 natural product Natural products 0.000 claims 1
- 239000003900 neurotrophic factor Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000016087 ovulation Effects 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 239000002210 silicon-based material Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR6024A AUPR602401A0 (en) | 2001-06-29 | 2001-06-29 | Sustained release delivery system |
| AUPR6024 | 2001-06-29 | ||
| PCT/AU2002/000866 WO2003009833A1 (en) | 2001-06-29 | 2002-07-01 | Sustained release delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004535473A JP2004535473A (ja) | 2004-11-25 |
| JP2004535473A5 true JP2004535473A5 (enExample) | 2005-10-27 |
| JP4913321B2 JP4913321B2 (ja) | 2012-04-11 |
Family
ID=3829990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515226A Expired - Fee Related JP4913321B2 (ja) | 2001-06-29 | 2002-07-01 | 徐放性医薬組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8197839B2 (enExample) |
| EP (1) | EP1411905A4 (enExample) |
| JP (1) | JP4913321B2 (enExample) |
| CN (1) | CN1536988A (enExample) |
| AU (2) | AUPR602401A0 (enExample) |
| BR (1) | BR0210630A (enExample) |
| CA (1) | CA2452075C (enExample) |
| NZ (1) | NZ529858A (enExample) |
| WO (1) | WO2003009833A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| JP2005505557A (ja) * | 2001-09-11 | 2005-02-24 | スマート ドラッグ システムズ インコーポレイティド | 持続放出医薬組成物の調製 |
| PT1696822E (pt) * | 2003-11-13 | 2010-04-28 | Psivida Inc | Implante de libertação controlada injectável com um núcleo de matriz biocorrosível e crosta biocorrosível |
| US20080044450A1 (en) * | 2004-05-31 | 2008-02-21 | Malcolm Brandon | Sustained Release Composition |
| EP2594259A1 (en) | 2004-08-04 | 2013-05-22 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
| US20110034498A1 (en) * | 2006-03-24 | 2011-02-10 | Mcgovern Karen J | Dosing regimens for the treatment of cancer |
| US20090005869A1 (en) * | 2006-12-15 | 2009-01-01 | University Of Virginia Patent Foundation | Device which Attaches into a Joint and Carries a Payload of Controlled Release Drugs and Related Method thereof |
| NZ552290A (en) * | 2006-12-21 | 2009-05-31 | Bomac Research Ltd | Tablet fomulation |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
| EP3190121B1 (en) | 2007-12-27 | 2019-02-20 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction of cyclopamine 4-en-3-one derivative |
| CA2710377A1 (en) * | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Therapeutic cancer treatments |
| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| US20120130300A1 (en) * | 2009-07-14 | 2012-05-24 | Board Of Regents, The Univerity Of Texas System | Therapeutic Methods Using Controlled Delivery Devices Having Zero Order Kinetics |
| WO2011017551A1 (en) | 2009-08-05 | 2011-02-10 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
| WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| ITTO20111188A1 (it) | 2011-12-22 | 2013-06-23 | Vhit Spa | Pompa a cilindrata variabile e metodo di regolazione della sua cilindrata |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
| FI20155779A7 (fi) * | 2015-10-30 | 2017-05-01 | Solani Therapeutics Ltd | Ei-steroidaalisen anti-inflammatorisen lääkkeen hidastetusti vapautuva annostelu |
| WO2019226519A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| EP3801462A4 (en) | 2018-05-24 | 2022-03-16 | Celanese EVA Performance Polymers LLC | Implantable device for sustained release of a macromolecular drug compound |
| WO2019222856A1 (en) | 2018-05-24 | 2019-11-28 | Nureva Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| CN110559431B (zh) * | 2019-10-11 | 2023-02-28 | 南京农业大学 | 一种巨型艾美耳球虫纳米亚单位疫苗及其制备方法和应用 |
| CA3164309A1 (en) * | 2020-01-10 | 2021-07-15 | Samuel D. Waksal | Treatment of neurological disorders with avermectins |
| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| CN116687882A (zh) * | 2023-07-06 | 2023-09-05 | 杭州高成生物营养技术有限公司 | 一种布洛芬缓释小丸及其制备方法 |
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| IL140899A0 (en) | 1998-07-17 | 2002-02-10 | Skyepharma Inc | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
| AU5532699A (en) | 1998-09-05 | 2000-03-27 | Seung Jin Lee | Biodegradable particulate polymeric preparation and process for producing thereof |
| US6756048B1 (en) * | 1998-09-10 | 2004-06-29 | Sumitomo Pharmaceuticals Company, Limited | Long time drug-sustained release preparation |
| US6645192B2 (en) | 1998-09-30 | 2003-11-11 | Ivy Animal Health, Inc. | Pellet implant system for immediate and delayed release of antiparasitic drug |
| WO2000018374A1 (en) * | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
| AU6526100A (en) * | 1999-08-06 | 2001-03-05 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
| JP4230621B2 (ja) | 1999-08-12 | 2009-02-25 | 住友ゴム工業株式会社 | 空気入りタイヤ |
| JP4757995B2 (ja) | 1999-11-10 | 2011-08-24 | 大日本住友製薬株式会社 | 薬物放出製剤 |
| TW524696B (en) | 1999-11-10 | 2003-03-21 | Sumitomo Pharma | Sustained-release drug formulations |
| WO2001037811A1 (en) * | 1999-11-22 | 2001-05-31 | Akzo Nobel N.V. | Composition allowing predefined and controlled release of active ingredient, preparation thereof and use |
| US6998137B2 (en) * | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
| JP4504122B2 (ja) | 2004-07-02 | 2010-07-14 | 株式会社マキタ | 生垣バリカン |
-
2001
- 2001-06-29 AU AUPR6024A patent/AUPR602401A0/en not_active Abandoned
-
2002
- 2002-07-01 AU AU2002344686A patent/AU2002344686B2/en not_active Expired
- 2002-07-01 EP EP02742516A patent/EP1411905A4/en not_active Withdrawn
- 2002-07-01 JP JP2003515226A patent/JP4913321B2/ja not_active Expired - Fee Related
- 2002-07-01 BR BR0210630-2A patent/BR0210630A/pt not_active IP Right Cessation
- 2002-07-01 CA CA2452075A patent/CA2452075C/en not_active Expired - Fee Related
- 2002-07-01 NZ NZ529858A patent/NZ529858A/en not_active IP Right Cessation
- 2002-07-01 WO PCT/AU2002/000866 patent/WO2003009833A1/en not_active Ceased
- 2002-07-01 CN CNA028131185A patent/CN1536988A/zh active Pending
- 2002-07-01 US US10/482,335 patent/US8197839B2/en active Active
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