JP2004535362A5 - - Google Patents
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- Publication number
- JP2004535362A5 JP2004535362A5 JP2002557917A JP2002557917A JP2004535362A5 JP 2004535362 A5 JP2004535362 A5 JP 2004535362A5 JP 2002557917 A JP2002557917 A JP 2002557917A JP 2002557917 A JP2002557917 A JP 2002557917A JP 2004535362 A5 JP2004535362 A5 JP 2004535362A5
- Authority
- JP
- Japan
- Prior art keywords
- administration
- powders
- freeze
- agents
- dried
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 229940029983 VITAMINS Drugs 0.000 description 1
- 229940021016 Vitamin IV solution additives Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000240 adjuvant Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- -1 coatings Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003204 osmotic Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002335 preservative Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000000699 topical Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamins Natural products 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Description
特に錠剤、ピル、被覆剤、カプセル剤、粉剤、顆粒剤、シロップ剤、ジュース、またはドロップは経口投与用に適切であり、座薬は直腸投与用に適切であり、更に溶液、好ましくは油性液または水溶液、更に懸濁液、乳液またはインプラントは、非経口投与に適切であり、軟膏、クリーム、または粉剤、もしくはスプレー式点鼻薬としての局所投与に適切である。新規化合物は凍結乾燥もでき、得られた凍結乾燥物を例えば、注射剤の調製に用いることができる。指摘した製剤は殺菌でき、および／または潤滑剤、保存剤、安定剤、および／または湿潤剤、乳化剤、浸透圧を修正する塩、緩衝剤、着色剤、および香味剤および／または複数の活性化合物、例えば１種または２種以上のビタミンなどの補助剤を含むこともできる。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10102322A DE10102322A1 (de) | 2001-01-19 | 2001-01-19 | Phenylderivate |
| PCT/EP2001/014296 WO2002057236A1 (en) | 2001-01-19 | 2001-12-05 | Phenyl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004535362A JP2004535362A (ja) | 2004-11-25 |
| JP2004535362A5 true JP2004535362A5 (ja) | 2006-02-09 |
| JP4180375B2 JP4180375B2 (ja) | 2008-11-12 |
Family
ID=7671098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557917A Expired - Fee Related JP4180375B2 (ja) | 2001-01-19 | 2001-12-05 | フェニル誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7273867B2 (ja) |
| EP (1) | EP1351938B1 (ja) |
| JP (1) | JP4180375B2 (ja) |
| KR (1) | KR20030072598A (ja) |
| CN (1) | CN1518541A (ja) |
| AT (1) | ATE359271T1 (ja) |
| AU (1) | AU2002227993B2 (ja) |
| BR (1) | BR0116804A (ja) |
| CA (1) | CA2434937C (ja) |
| CZ (1) | CZ20032151A3 (ja) |
| DE (2) | DE10102322A1 (ja) |
| ES (1) | ES2284718T3 (ja) |
| HU (1) | HUP0500110A2 (ja) |
| MX (1) | MXPA03006483A (ja) |
| PL (1) | PL362834A1 (ja) |
| RU (1) | RU2003124072A (ja) |
| SK (1) | SK10142003A3 (ja) |
| WO (1) | WO2002057236A1 (ja) |
| ZA (1) | ZA200306419B (ja) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10139060A1 (de) | 2001-08-08 | 2003-02-20 | Merck Patent Gmbh | Phenylderivate |
| US7030141B2 (en) | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| DE10204072A1 (de) * | 2002-01-31 | 2003-08-14 | Morphochem Ag Komb Chemie | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| DE10214832A1 (de) * | 2002-04-04 | 2003-10-16 | Merck Patent Gmbh | Phenylderivate 4 |
| JP4567439B2 (ja) * | 2002-04-27 | 2010-10-20 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | カルボン酸アミド |
| WO2004031145A2 (en) * | 2002-10-02 | 2004-04-15 | Bristol-Myers Squibb Company | Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor xa inhibitors |
| DE10254336A1 (de) | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
| JP2006517589A (ja) * | 2003-02-11 | 2006-07-27 | ブリストル−マイヤーズ スクイブ カンパニー | セリンプロテアーゼ・インヒビターとして有用なベンゼンアセトアミド化合物 |
| DE10308907A1 (de) * | 2003-02-28 | 2004-09-09 | Merck Patent Gmbh | Ethynylderivate |
| US7205318B2 (en) * | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
| US7135469B2 (en) | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
| AU2004226278B2 (en) * | 2003-04-03 | 2010-07-29 | Merck Patent Gmbh | Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxo-morpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor Xa in the treatment of thrombo-embolic diseases |
| US7250415B2 (en) | 2003-06-04 | 2007-07-31 | Bristol-Myers Squibb Company | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors |
| DE10336716A1 (de) | 2003-08-11 | 2005-03-10 | Merck Patent Gmbh | Verfahren zur Herstellung von N-Aryl-morpholinonen |
| WO2005020921A2 (en) * | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | C-kit modulators and methods of use |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| EP1571154A1 (en) * | 2004-03-03 | 2005-09-07 | Aventis Pharma Deutschland GmbH | Beta-aminoacid-derivatives as factor Xa inhibitors |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| US7625949B2 (en) | 2004-04-23 | 2009-12-01 | Roche Palo Alto Llc | Methods for treating retroviral infections |
| US7511035B2 (en) | 2005-01-25 | 2009-03-31 | Glaxo Group Limited | Antibacterial agents |
| EP1893583B1 (en) | 2005-05-31 | 2012-04-04 | Pfizer Inc. | Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists |
| EP1910298B1 (en) * | 2005-06-24 | 2010-01-13 | Brystol-Myers Squibb Company | Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants |
| CA2624102A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| WO2007045573A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
| EP1996541B1 (en) * | 2006-03-09 | 2014-04-23 | Bristol-Myers Squibb Company | 2-(aryloxy)acetamide factor viia inhibitors useful as anticoagulants |
| WO2008076805A2 (en) * | 2006-12-15 | 2008-06-26 | Bristol-Myers Squibb Company | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
| WO2009075874A1 (en) * | 2007-12-13 | 2009-06-18 | Amgen Inc. | Gamma secretase modulators |
| JP2014523400A (ja) * | 2011-04-20 | 2014-09-11 | ビオタ サイエンティフィック マネジメント プティ リミテッド | 芳香族アミド類およびそれらの使用 |
| CA2929753A1 (en) | 2013-11-08 | 2015-05-14 | Bayer Pharma Aktiengesellschaft | Substituted uracils and use thereof |
| CN105440020B (zh) * | 2013-12-10 | 2018-12-18 | 常州大学 | 具有抗肿瘤活性的1,2,3-三唑类化合物及其制备方法 |
| US10471023B2 (en) | 2015-03-12 | 2019-11-12 | British Columbia Cancer Agency Branch | Bisphenol ether derivatives and methods for using the same |
| BR112018011562B1 (pt) * | 2015-12-09 | 2023-05-02 | F. Hoffmann-La Roche Ag | Novos derivados de fenil |
| CN108558741B (zh) * | 2017-12-27 | 2020-10-30 | 浙江天宇药业股份有限公司 | 一种阿哌沙班的中间体的合成方法 |
| WO2019226991A1 (en) | 2018-05-25 | 2019-11-28 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| EP3867216A4 (en) | 2018-10-18 | 2022-07-13 | Essa Pharma, Inc. | ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF |
| KR20230004498A (ko) | 2020-04-17 | 2023-01-06 | 에싸 파마 아이엔씨. | N-말단 도메인 안드로겐 수용체 억제제의 고형분 형태 및 이의 용도 |
| CN112624930A (zh) * | 2020-12-21 | 2021-04-09 | 上海如鲲新材料有限公司 | 一种2,2-双（4-氨基苯基）六氟丙烷的制备方法 |
| US11596612B1 (en) | 2022-03-08 | 2023-03-07 | PTC Innovations, LLC | Topical anesthetics |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2361327A (en) * | 1940-07-12 | 1944-10-24 | Du Pont | Aryloxy-alkacyl-arylenes |
| DE2926049A1 (de) * | 1979-06-28 | 1981-01-08 | Basf Ag | M-anilidurethane und diese enthaltende herbizide |
| DE19743435A1 (de) | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| JP2003500386A (ja) * | 1999-05-24 | 2003-01-07 | シーオーアール セラピューティクス インコーポレイテッド | Ｘａ因子阻害剤 |
| DE10035144A1 (de) * | 2000-07-19 | 2002-01-31 | Merck Patent Gmbh | Cyclische Aminosäurederivate |
-
2001
- 2001-01-19 DE DE10102322A patent/DE10102322A1/de not_active Withdrawn
- 2001-12-05 ES ES01989580T patent/ES2284718T3/es not_active Expired - Lifetime
- 2001-12-05 CA CA2434937A patent/CA2434937C/en not_active Expired - Fee Related
- 2001-12-05 CN CNA01823061XA patent/CN1518541A/zh active Pending
- 2001-12-05 EP EP01989580A patent/EP1351938B1/en not_active Expired - Lifetime
- 2001-12-05 PL PL01362834A patent/PL362834A1/xx unknown
- 2001-12-05 SK SK1014-2003A patent/SK10142003A3/sk not_active Application Discontinuation
- 2001-12-05 AT AT01989580T patent/ATE359271T1/de not_active IP Right Cessation
- 2001-12-05 US US10/466,680 patent/US7273867B2/en not_active Expired - Fee Related
- 2001-12-05 CZ CZ20032151A patent/CZ20032151A3/cs unknown
- 2001-12-05 RU RU2003124072/04A patent/RU2003124072A/ru not_active Application Discontinuation
- 2001-12-05 DE DE60127863T patent/DE60127863T2/de not_active Expired - Lifetime
- 2001-12-05 MX MXPA03006483A patent/MXPA03006483A/es unknown
- 2001-12-05 JP JP2002557917A patent/JP4180375B2/ja not_active Expired - Fee Related
- 2001-12-05 WO PCT/EP2001/014296 patent/WO2002057236A1/en active IP Right Grant
- 2001-12-05 KR KR10-2003-7009492A patent/KR20030072598A/ko not_active Application Discontinuation
- 2001-12-05 BR BR0116804-5A patent/BR0116804A/pt not_active IP Right Cessation
- 2001-12-05 HU HU0500110A patent/HUP0500110A2/hu unknown
- 2001-12-05 AU AU2002227993A patent/AU2002227993B2/en not_active Ceased
-
2003
- 2003-08-18 ZA ZA200306419A patent/ZA200306419B/xx unknown
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