JP2004535185A5 - - Google Patents

Info

Publication number

JP2004535185A5

JP2004535185A5 JP2003500285A JP2003500285A JP2004535185A5 JP 2004535185 A5 JP2004535185 A5 JP 2004535185A5 JP 2003500285 A JP2003500285 A JP 2003500285A JP 2003500285 A JP2003500285 A JP 2003500285A JP 2004535185 A5 JP2004535185 A5 JP 2004535185A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

amino acids

ham

sequence

Prior art date

2002-05-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 60
• 102000004196 processed proteins & peptides Human genes 0.000 claims 59
• 229920001184 polypeptide Polymers 0.000 claims 58
• 150000001413 amino acids Chemical class 0.000 claims 22
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 16
• 238000000034 method Methods 0.000 claims 15
• 102000040430 polynucleotide Human genes 0.000 claims 12
• 108091033319 polynucleotide Proteins 0.000 claims 12
• 239000002157 polynucleotide Substances 0.000 claims 12
• 239000003795 chemical substances by application Substances 0.000 claims 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 230000000694 effects Effects 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 239000000523 sample Substances 0.000 claims 7
• 208000035475 disorder Diseases 0.000 claims 6
• 239000013598 vector Substances 0.000 claims 6
• 230000004927 fusion Effects 0.000 claims 5
• 239000002773 nucleotide Substances 0.000 claims 4
• 125000003729 nucleotide group Chemical group 0.000 claims 4
• 238000005259 measurement Methods 0.000 claims 3
• 239000012472 biological sample Substances 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 239000000816 peptidomimetic Substances 0.000 claims 2
• 150000003384 small molecules Chemical class 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000020084 Bone disease Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 208000025966 Neurological disease Diseases 0.000 claims 1
• 238000000636 Northern blotting Methods 0.000 claims 1
• 208000025747 Rheumatic disease Diseases 0.000 claims 1
• 210000001185 bone marrow Anatomy 0.000 claims 1
• 208000035269 cancer or benign tumor Diseases 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000014951 hematologic disease Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 208000019423 liver disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 230000023105 myelination Effects 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 239000008024 pharmaceutical diluent Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1