JP2004534527A5 - - Google Patents
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- Publication number
- JP2004534527A5 JP2004534527A5 JP2002580036A JP2002580036A JP2004534527A5 JP 2004534527 A5 JP2004534527 A5 JP 2004534527A5 JP 2002580036 A JP2002580036 A JP 2002580036A JP 2002580036 A JP2002580036 A JP 2002580036A JP 2004534527 A5 JP2004534527 A5 JP 2004534527A5
- Authority
- JP
- Japan
- Prior art keywords
- lactase
- lactase solution
- solution according
- sterilized
- milk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100026189 Beta-galactosidase Human genes 0.000 claims 23
- 108010059881 Lactase Proteins 0.000 claims 23
- 108010005774 beta-Galactosidase Proteins 0.000 claims 23
- 229940116108 lactase Drugs 0.000 claims 23
- 239000000243 solution Substances 0.000 claims 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 5
- 229920001542 oligosaccharide Polymers 0.000 claims 5
- 150000002482 oligosaccharides Chemical class 0.000 claims 5
- 229920001282 polysaccharide Polymers 0.000 claims 5
- 239000005017 polysaccharide Substances 0.000 claims 5
- 235000013336 milk Nutrition 0.000 claims 4
- 239000008267 milk Substances 0.000 claims 4
- 210000004080 milk Anatomy 0.000 claims 4
- 230000000087 stabilizing effect Effects 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 238000011210 chromatographic step Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000020191 long-life milk Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 235000020200 pasteurised milk Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01000102 | 2001-04-04 | ||
| PCT/EP2002/003680 WO2002081673A1 (en) | 2001-04-04 | 2002-04-03 | Purified lactase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008295983A Division JP2009034116A (ja) | 2001-04-04 | 2008-11-19 | 精製ラクターゼ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534527A JP2004534527A (ja) | 2004-11-18 |
| JP2004534527A5 true JP2004534527A5 (https=) | 2005-12-22 |
Family
ID=8176033
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580036A Pending JP2004534527A (ja) | 2001-04-04 | 2002-04-03 | 精製ラクターゼ |
| JP2008295983A Pending JP2009034116A (ja) | 2001-04-04 | 2008-11-19 | 精製ラクターゼ |
| JP2010036310A Pending JP2010148516A (ja) | 2001-04-04 | 2010-02-22 | 精製ラクターゼ |
| JP2013036972A Pending JP2013099364A (ja) | 2001-04-04 | 2013-02-27 | 精製ラクターゼ |
| JP2013221129A Pending JP2014050399A (ja) | 2001-04-04 | 2013-10-24 | 精製ラクターゼ |
| JP2015196009A Pending JP2016000058A (ja) | 2001-04-04 | 2015-10-01 | 精製ラクターゼ |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008295983A Pending JP2009034116A (ja) | 2001-04-04 | 2008-11-19 | 精製ラクターゼ |
| JP2010036310A Pending JP2010148516A (ja) | 2001-04-04 | 2010-02-22 | 精製ラクターゼ |
| JP2013036972A Pending JP2013099364A (ja) | 2001-04-04 | 2013-02-27 | 精製ラクターゼ |
| JP2013221129A Pending JP2014050399A (ja) | 2001-04-04 | 2013-10-24 | 精製ラクターゼ |
| JP2015196009A Pending JP2016000058A (ja) | 2001-04-04 | 2015-10-01 | 精製ラクターゼ |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7955831B2 (https=) |
| EP (2) | EP1373491B1 (https=) |
| JP (6) | JP2004534527A (https=) |
| CN (1) | CN100447242C (https=) |
| DK (2) | DK2280065T3 (https=) |
| ES (2) | ES2564821T3 (https=) |
| PT (2) | PT2280065T (https=) |
| WO (1) | WO2002081673A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1373491B1 (en) * | 2001-04-04 | 2015-12-30 | DSM IP Assets B.V. | Purified lactase |
| AU2013200779C1 (en) * | 2005-11-28 | 2022-11-10 | Dsm Ip Assets B.V. | Enzyme preparations yielding a clean taste |
| ES2454167T3 (es) | 2005-11-28 | 2014-04-09 | Dsm Ip Assets B.V. | Preparación de enzima que produce un sabor puro |
| US8236297B2 (en) * | 2007-10-11 | 2012-08-07 | Kenneth Manzo | Method of treating lactose intolerance using genetically engineered bacteria |
| ES2591359T3 (es) | 2007-12-03 | 2016-11-28 | Novozymes A/S | Método para producir un producto lácteo de bajo contenido en lactosa |
| EP2272374B1 (en) | 2009-06-23 | 2015-01-14 | Nestec S.A. | Lactase containing milk powder |
| US20140087404A1 (en) * | 2011-03-14 | 2014-03-27 | Godo Shusei Co., Ltd. | Method for assaying arylsulfatase activity |
| WO2014185364A1 (ja) | 2013-05-13 | 2014-11-20 | 合同酒精株式会社 | ラクターゼ含有組成物の製造法 |
| US10201178B2 (en) * | 2014-03-05 | 2019-02-12 | Dsm Ip Assets B.V. | Stable liquid lactase compositions |
| EP3187582B1 (en) * | 2014-08-27 | 2025-07-23 | Godo Shusei Co., Ltd. | Lactase solution |
| WO2016060224A1 (ja) * | 2014-10-17 | 2016-04-21 | 合同酒精株式会社 | ラクターゼ溶液及びそれを用いた乳 |
| BR112017011607A2 (pt) | 2014-12-05 | 2018-01-09 | Godo Shusei Kk | solução de lactase e produto lácteo usando a mesma |
| AR107872A1 (es) | 2016-03-16 | 2018-06-13 | Godo Sushei Co Ltd | Proteinasa b y solución de lactasa usando sus propiedades y método para producirlo |
| WO2018130654A1 (en) * | 2017-01-13 | 2018-07-19 | Novozymes A/S | Sterile filtered lactase preparation comprising salt with monovalent cation |
| US11517613B2 (en) * | 2017-06-07 | 2022-12-06 | Amano Enzyme Inc. | Lactase bulk powder and lactase preparation |
| CN107858342B (zh) * | 2017-10-11 | 2020-09-25 | 华中农业大学 | 一种稳定的乳糖酶液态制剂 |
| WO2021134002A1 (en) | 2019-12-26 | 2021-07-01 | Pharmunion, LLC | Stable lactase product |
| JP7706443B2 (ja) * | 2020-04-17 | 2025-07-11 | 合同酒精株式会社 | 容器詰めラクターゼ溶液 |
| US20250049057A1 (en) | 2021-09-07 | 2025-02-13 | Godo Shusei Co., Ltd. | Lactase, lactase preparation, gene, recombinant vector, and transformant |
| JPWO2023106420A1 (https=) | 2021-12-09 | 2023-06-15 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1306751A (en) * | 1971-01-26 | 1973-02-14 | Baxter Laboratories Inc | Lactase enzyme production |
| US3753725A (en) | 1971-03-11 | 1973-08-21 | R Williams | Method for enzymatic conversion of lactose to glucose and galactose in lactose containing fluids |
| US3919049A (en) | 1974-06-27 | 1975-11-11 | Tokyo Tanabe Co | Process for preparing {62 -galactosidase |
| SE438773B (sv) | 1974-11-13 | 1985-05-13 | Tetra Pak Int | Sett att framstella en steril mejeriprodukt med nedsatt halt av laktos |
| US4007283A (en) * | 1975-10-28 | 1977-02-08 | The Regents Of The University Of California | Production and utilization of lactase |
| JPS53148591A (en) * | 1977-05-31 | 1978-12-25 | Daiwa Kasei Kk | Production of novel lactase |
| JPS5571445A (en) | 1978-11-24 | 1980-05-29 | Morinaga Milk Ind Co Ltd | Production of lactose hydrolyzate |
| DE3064347D1 (en) * | 1979-02-06 | 1983-09-01 | Procter & Gamble | Soap bars |
| JPS5651984A (en) | 1979-10-02 | 1981-05-09 | Sumitomo Chem Co Ltd | Fixed lactase and its preparation |
| JPS56140890A (en) | 1980-04-04 | 1981-11-04 | Sumitomo Chem Co Ltd | Immobilized lactase and its preparation |
| FR2500269A1 (fr) | 1981-02-20 | 1982-08-27 | Tetra Pak Int | Procede pour le traitement des produits laitiers pour diminuer leur teneur en lactose notamment |
| JPS59175879A (ja) | 1983-03-25 | 1984-10-04 | Snow Brand Milk Prod Co Ltd | 酵素における汚染細菌の殺菌法 |
| AU586809B2 (en) | 1983-12-02 | 1989-07-27 | Gist-Brocades N.V. | Process for the preparation of a germ free solution of a lactose-splitting enzyme and its use. |
| US5283189A (en) | 1987-02-09 | 1994-02-01 | Research Development Corporation Of Japan | β-galactosidase from Thermus sp |
| US5357852A (en) | 1992-06-02 | 1994-10-25 | Kohler Mix Specialties | Method and apparatus for producing reduced lactose milk |
| US5744345A (en) * | 1992-10-05 | 1998-04-28 | Takara Shuzo Co., Ltd. | Hyperthermostable β-galactosidase gene, enzyme encoded thereby, and process for production |
| US5821350A (en) | 1995-11-01 | 1998-10-13 | Nexia Biotechnologies, Inc. | Aspergillus niger beta-galactosidase gene |
| ES2130991B1 (es) | 1997-05-16 | 2000-04-01 | Plumley Kevin More | Procedimiento que implica la pre-digestion parcial en una linea de produccion para la elaboracion de leche y derivados lacteos libres de lactosa para evitar descargas de 5-hidroxi-triptamina - o 5-ht. |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| EP1261697B1 (en) * | 1999-07-09 | 2004-07-28 | Université de Liège | Cold-active beta galactosidase, the process for its preparation and the use thereof |
| EP1373491B1 (en) | 2001-04-04 | 2015-12-30 | DSM IP Assets B.V. | Purified lactase |
-
2002
- 2002-04-03 EP EP02759791.3A patent/EP1373491B1/en not_active Revoked
- 2002-04-03 ES ES02759791.3T patent/ES2564821T3/es not_active Expired - Lifetime
- 2002-04-03 ES ES10176987T patent/ES2858527T3/es not_active Expired - Lifetime
- 2002-04-03 PT PT101769875T patent/PT2280065T/pt unknown
- 2002-04-03 CN CNB028072863A patent/CN100447242C/zh not_active Ceased
- 2002-04-03 WO PCT/EP2002/003680 patent/WO2002081673A1/en not_active Ceased
- 2002-04-03 JP JP2002580036A patent/JP2004534527A/ja active Pending
- 2002-04-03 DK DK10176987.5T patent/DK2280065T3/da active
- 2002-04-03 DK DK02759791.3T patent/DK1373491T3/en active
- 2002-04-03 PT PT2759791T patent/PT1373491E/pt unknown
- 2002-04-03 US US10/474,113 patent/US7955831B2/en not_active Expired - Lifetime
- 2002-04-03 EP EP10176987.5A patent/EP2280065B1/en not_active Expired - Lifetime
-
2008
- 2008-11-19 JP JP2008295983A patent/JP2009034116A/ja active Pending
-
2010
- 2010-02-22 JP JP2010036310A patent/JP2010148516A/ja active Pending
-
2011
- 2011-05-05 US US13/067,065 patent/US9149048B2/en not_active Expired - Lifetime
-
2013
- 2013-02-27 JP JP2013036972A patent/JP2013099364A/ja active Pending
- 2013-10-24 JP JP2013221129A patent/JP2014050399A/ja active Pending
-
2015
- 2015-08-27 US US14/837,275 patent/US9763460B2/en not_active Expired - Fee Related
- 2015-10-01 JP JP2015196009A patent/JP2016000058A/ja active Pending
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