JP2004534062A - Ｘａ因子インヒビター - Google Patents

Ｘａ因子インヒビター Download PDF

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Publication number
JP2004534062A
JP2004534062A JP2003503615A JP2003503615A JP2004534062A JP 2004534062 A JP2004534062 A JP 2004534062A JP 2003503615 A JP2003503615 A JP 2003503615A JP 2003503615 A JP2003503615 A JP 2003503615A JP 2004534062 A JP2004534062 A JP 2004534062A
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JP
Japan
Prior art keywords
difumarate
piperazine
phenylglycinyl
indole
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003503615A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004534062A5 (enExample
Inventor
ゲイリー・ローウェル・エンゲル
ベンジャミン・アラン・ディスロード
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2001/002553 external-priority patent/WO2001096323A1/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JP2004534062A publication Critical patent/JP2004534062A/ja
Publication of JP2004534062A5 publication Critical patent/JP2004534062A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2003503615A 2001-06-12 2002-06-06 Ｘａ因子インヒビター Pending JP2004534062A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2001/002553 WO2001096323A1 (en) 2000-06-13 2001-06-12 Serine protease inhibitors
US33929501P 2001-12-12 2001-12-12
PCT/US2002/016569 WO2002100847A2 (en) 2001-06-12 2002-06-06 Factor xa inhibitor

Publications (2)

Publication Number Publication Date
JP2004534062A true JP2004534062A (ja) 2004-11-11
JP2004534062A5 JP2004534062A5 (enExample) 2005-12-22

Family

ID=41210812

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003503615A Pending JP2004534062A (ja) 2001-06-12 2002-06-06 Ｘａ因子インヒビター

Country Status (13)

Country Link
US (1) US20040162295A1 (enExample)
EP (1) EP1397348B1 (enExample)
JP (1) JP2004534062A (enExample)
AR (1) AR036048A1 (enExample)
AT (1) ATE305452T1 (enExample)
AU (1) AU2002348501A1 (enExample)
DE (1) DE60206376T2 (enExample)
ES (1) ES2248618T3 (enExample)
MY (1) MY137876A (enExample)
PE (1) PE20030198A1 (enExample)
SV (1) SV2003001085A (enExample)
TW (1) TWI257389B (enExample)
WO (1) WO2002100847A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015524400A (ja) * 2012-07-19 2015-08-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE384713T1 (de) * 2001-07-26 2008-02-15 Lilly Co Eli 1-glycinyl-4-(1-methylpiperidin-4-yl)piperazine und -piperidine als faktor-xa-antagonisten
IL164018A0 (en) 2002-04-01 2005-12-18 Lilly Co Eli Certain 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazine compounds as inhibitors of the serineprotease factor xa
EA010307B1 (ru) * 2004-06-30 2008-08-29 Эли Лилли Энд Компани Фармацевтическое соединение
KR100849242B1 (ko) * 2004-06-30 2008-07-29 일라이 릴리 앤드 캄파니 1(인돌-6-카르보닐-ｄ-페닐글리시닐)-4-(1-메틸피페리딘-4-일) 피페라진 ｄ-타르트레이트
DE102007028407A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076971A2 (en) * 1999-06-14 2000-12-21 Eli Lilly And Company Serine protease inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0030304D0 (en) * 2000-12-13 2001-01-24 Lilly Co Eli Compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076971A2 (en) * 1999-06-14 2000-12-21 Eli Lilly And Company Serine protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
長瀬博監訳, 最新 創薬化学 下巻 , JPN6008054607, 25 September 1999 (1999-09-25), JP, pages 347 - 365, ISSN: 0001167457 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015524400A (ja) * 2012-07-19 2015-08-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製

Also Published As

Publication number Publication date
EP1397348A2 (en) 2004-03-17
PE20030198A1 (es) 2003-03-12
SV2003001085A (es) 2003-03-18
ATE305452T1 (de) 2005-10-15
WO2002100847A3 (en) 2003-08-21
MY137876A (en) 2009-03-31
EP1397348B1 (en) 2005-09-28
TWI257389B (en) 2006-07-01
US20040162295A1 (en) 2004-08-19
DE60206376D1 (de) 2006-02-09
DE60206376T2 (de) 2006-06-22
AU2002348501A1 (en) 2002-12-23
ES2248618T3 (es) 2006-03-16
WO2002100847A2 (en) 2002-12-19
AR036048A1 (es) 2004-08-04

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