JP2004534011A5 - - Google Patents
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- Publication number
- JP2004534011A5 JP2004534011A5 JP2002577844A JP2002577844A JP2004534011A5 JP 2004534011 A5 JP2004534011 A5 JP 2004534011A5 JP 2002577844 A JP2002577844 A JP 2002577844A JP 2002577844 A JP2002577844 A JP 2002577844A JP 2004534011 A5 JP2004534011 A5 JP 2004534011A5
- Authority
- JP
- Japan
- Prior art keywords
- pregna
- methyl
- substituted
- dien
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 steroid compound Chemical class 0.000 claims 57
- 238000000034 method Methods 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 150000003431 steroids Chemical group 0.000 claims 3
- OTDOTSOSVDUYPU-VUVUMNNWSA-N (3s,5r,10s,13r,17r)-17-[(2s)-1-(3,3-dimethylpiperidin-1-yl)propan-2-yl]-4,4,10,13-tetramethyl-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N1CCCC(C)(C)C1 OTDOTSOSVDUYPU-VUVUMNNWSA-N 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000003172 aldehyde group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000001993 dienes Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 230000021121 meiosis Effects 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 150000002825 nitriles Chemical class 0.000 claims 2
- 230000000269 nucleophilic effect Effects 0.000 claims 2
- 210000000287 oocyte Anatomy 0.000 claims 2
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- JEPXCLDRHLFCEA-VUVUMNNWSA-N (3s,5r,10s,13r,17r)-17-[(2s)-1-(4,4-dimethylpiperidin-1-yl)propan-2-yl]-4,4,10,13-tetramethyl-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N1CCC(C)(C)CC1 JEPXCLDRHLFCEA-VUVUMNNWSA-N 0.000 claims 1
- IZICFEGIZNHACS-PBJLWWPKSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-1-(4-methylpiperazin-1-yl)propan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N1CCN(C)CC1 IZICFEGIZNHACS-PBJLWWPKSA-N 0.000 claims 1
- WOTNUNXNDARBRO-LBLATDDSSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-1-(4-phenylpiperazin-1-yl)propan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N(CC1)CCN1C1=CC=CC=C1 WOTNUNXNDARBRO-LBLATDDSSA-N 0.000 claims 1
- GKBHGYCSYJXRHT-NLUWZDHDSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-1-(4-pyrimidin-2-ylpiperazin-1-yl)propan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N(CC1)CCN1C1=NC=CC=N1 GKBHGYCSYJXRHT-NLUWZDHDSA-N 0.000 claims 1
- FYPIHEPJWGYYNN-ACDJPIBPSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-1-morpholin-4-ylpropan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N1CCOCC1 FYPIHEPJWGYYNN-ACDJPIBPSA-N 0.000 claims 1
- ICXINXKOXHSQBO-PBJLWWPKSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-1-piperidin-1-ylpropan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N1CCCCC1 ICXINXKOXHSQBO-PBJLWWPKSA-N 0.000 claims 1
- IJNGCTNYTIGKDI-ACDJPIBPSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-1-pyrrolidin-1-ylpropan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)N1CCCC1 IJNGCTNYTIGKDI-ACDJPIBPSA-N 0.000 claims 1
- QFPWLFITQPUXHV-KFAAVVAUSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-4-(4-methylpiperazin-1-yl)butan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)CN1CCN(C)CC1 QFPWLFITQPUXHV-KFAAVVAUSA-N 0.000 claims 1
- WUWQKXKAYAZHIN-BYBMNWGSSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-4-(4-phenylpiperazin-1-yl)butan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)CN(CC1)CCN1C1=CC=CC=C1 WUWQKXKAYAZHIN-BYBMNWGSSA-N 0.000 claims 1
- PKWNVYQEFUMSKR-ANKUBJOSSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)CN(CC1)CCN1C1=CC=CC=N1 PKWNVYQEFUMSKR-ANKUBJOSSA-N 0.000 claims 1
- DTTSEYLDUMDCLH-BQPBCQRUSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-4-morpholin-4-ylbutan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)CN1CCOCC1 DTTSEYLDUMDCLH-BQPBCQRUSA-N 0.000 claims 1
- QRENNSDRNOUTTJ-KFAAVVAUSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-4-piperidin-1-ylbutan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)CN1CCCCC1 QRENNSDRNOUTTJ-KFAAVVAUSA-N 0.000 claims 1
- JMUXKHOLEWUZTE-BQPBCQRUSA-N (3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2s)-4-pyrrolidin-1-ylbutan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@H](C)[C@@H]1[C@]2(CCC3=C(CC[C@H]4C(C)(C)[C@@H](O)CC[C@@]43C)C2=CC1)C)CN1CCCC1 JMUXKHOLEWUZTE-BQPBCQRUSA-N 0.000 claims 1
- OSHHWCYAGNHCHJ-SRJXFZCCSA-N (3s,9s,10r,13r,14r,17r)-4,4,10,13-tetramethyl-17-[(2s)-1-piperidin-1-ylpropan-2-yl]-1,2,3,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H](C)[C@@H]1[C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)C(C)(C)C4=CC=C3[C@@H]2CC1)C)N1CCCCC1 OSHHWCYAGNHCHJ-SRJXFZCCSA-N 0.000 claims 1
- ZNWOYQVXPIEQRC-HOFZUOGSSA-N (8s,9s,10r,13s,14s,17r)-17-[(2s)-1-hydroxypropan-2-yl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CO)C)[C@@]1(C)CC2 ZNWOYQVXPIEQRC-HOFZUOGSSA-N 0.000 claims 1
- MZAGXDHQGXUDDX-JSRXJHBZSA-N (e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/C(N)=O MZAGXDHQGXUDDX-JSRXJHBZSA-N 0.000 claims 1
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical group N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 230000031709 bromination Effects 0.000 claims 1
- 238000005893 bromination reaction Methods 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000002254 contraceptive effect Effects 0.000 claims 1
- 150000004292 cyclic ethers Chemical class 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 238000007269 dehydrobromination reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 230000035558 fertility Effects 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000000593 indol-1-yl group Chemical group [H]C1=C([H])C([H])=C2N([*])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01250108A EP1245572A1 (en) | 2001-03-26 | 2001-03-26 | Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation |
| PCT/EP2002/003148 WO2002079220A2 (en) | 2001-03-26 | 2002-03-20 | Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534011A JP2004534011A (ja) | 2004-11-11 |
| JP2004534011A5 true JP2004534011A5 (cg-RX-API-DMAC10.html) | 2005-06-09 |
Family
ID=8181575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002577844A Pending JP2004534011A (ja) | 2001-03-26 | 2002-03-20 | ステロイド化合物類、減数分裂−調節薬剤の調製のためのそれらの化合物の使用、及びそれらの化合物の調製方法 |
Country Status (18)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1514874A1 (en) * | 2003-07-28 | 2005-03-16 | Schering Aktiengesellschaft | Thiomorpholino steroid compounds, the use thereof for the preparation of meiosis regulating medicaments and method for the preparation thereof |
| KR100689260B1 (ko) * | 2005-05-24 | 2007-03-02 | 삼원산업주식회사 | 항산화성 스틸벤계 형광증백제 및 이의 합성방법 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1095167A (en) * | 1963-12-05 | 1967-12-13 | Shalom Sarel | Amino-steroids |
| US3419661A (en) * | 1964-01-13 | 1968-12-31 | Univ Missouri | Oral contraceptive for birds |
| DE1643004A1 (de) * | 1967-02-07 | 1971-04-08 | Schering Ag | Bisnorcholenderivate und Verfahren zu ihrer Herstellung |
| DE1930473A1 (de) * | 1969-06-14 | 1970-12-17 | Schering Ag | 22-N-substituierte (20R)-23,24-dinor-cholanderivate |
| US5716777A (en) | 1994-06-23 | 1998-02-10 | Novo Nordisk A/S | Regulation of meiosis using sterols |
| EP0813595A1 (en) * | 1995-03-06 | 1997-12-29 | Novo Nordisk A/S | Stimulation of meiosis |
| ATE254628T1 (de) | 1995-06-23 | 2003-12-15 | Novo Nordisk As | Meiose regulierende verbindungen. |
| EP0946584B1 (en) | 1996-12-20 | 2003-04-23 | Novo Nordisk A/S | Meiosis regulating compounds |
| JP2003522728A (ja) * | 1998-05-13 | 2003-07-29 | ノボ ノルディスク アクティーゼルスカブ | 減数分裂調節化合物 |
| KR20010043828A (ko) | 1998-05-26 | 2001-05-25 | 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 | ｃＡＭＰ-증강 화합물 단독 또는 감수분열-자극 화합물하나 이상과의 조합에 의한 불임 치료 방법 |
| EP1156821B1 (en) | 1999-02-24 | 2007-05-02 | Novo Nordisk A/S | Treatment of infertility |
| AU2794100A (en) | 1999-02-24 | 2000-09-14 | Novo Nordisk A/S | Treatment of infertility |
| CN1341147A (zh) | 1999-02-26 | 2002-03-20 | 诺沃挪第克公司 | 减数分裂活化甾醇增大着床率 |
| JP2003509365A (ja) | 1999-09-16 | 2003-03-11 | ノボ ノルディスク アクティーゼルスカブ | Ｉｖｆ用の組成物 |
| AU3376501A (en) | 2000-02-25 | 2001-09-03 | Novo Nordisk A/S | Improvement of implantation rate |
| US6988613B2 (en) * | 2001-02-06 | 2006-01-24 | Novo Nordisk A/S | Composition for IVF |
| ATE386495T1 (de) * | 2001-02-06 | 2008-03-15 | Novo Nordisk As | Behältnis mit niedrigem sauerstoffgehalt, das ff- mas enthält |
-
2001
- 2001-03-26 EP EP01250108A patent/EP1245572A1/en not_active Withdrawn
-
2002
- 2002-03-20 AU AU2002315260A patent/AU2002315260B2/en not_active Ceased
- 2002-03-20 UA UA2003109610A patent/UA75130C2/uk unknown
- 2002-03-20 MX MXPA03008199A patent/MXPA03008199A/es active IP Right Grant
- 2002-03-20 WO PCT/EP2002/003148 patent/WO2002079220A2/en not_active Ceased
- 2002-03-20 HU HU0303643A patent/HUP0303643A2/hu unknown
- 2002-03-20 IL IL15727202A patent/IL157272A0/xx unknown
- 2002-03-20 KR KR10-2003-7012456A patent/KR20030088043A/ko not_active Ceased
- 2002-03-20 BR BR0208381-7A patent/BR0208381A/pt not_active IP Right Cessation
- 2002-03-20 CN CNB028073673A patent/CN1332975C/zh not_active Expired - Fee Related
- 2002-03-20 RU RU2003130228/04A patent/RU2289587C2/ru not_active IP Right Cessation
- 2002-03-20 CZ CZ20032578A patent/CZ20032578A3/cs unknown
- 2002-03-20 CA CA002438210A patent/CA2438210A1/en not_active Abandoned
- 2002-03-20 PL PL02369576A patent/PL369576A1/xx not_active Application Discontinuation
- 2002-03-20 EP EP02740430A patent/EP1401856A2/en not_active Withdrawn
- 2002-03-20 JP JP2002577844A patent/JP2004534011A/ja active Pending
- 2002-03-26 US US10/105,939 patent/US6916921B2/en not_active Expired - Fee Related
-
2003
- 2003-09-25 NO NO20034273A patent/NO20034273L/no not_active Application Discontinuation
- 2003-10-23 ZA ZA200308271A patent/ZA200308271B/xx unknown
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