JP2004533826A5 - - Google Patents
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- Publication number
- JP2004533826A5 JP2004533826A5 JP2002582235A JP2002582235A JP2004533826A5 JP 2004533826 A5 JP2004533826 A5 JP 2004533826A5 JP 2002582235 A JP2002582235 A JP 2002582235A JP 2002582235 A JP2002582235 A JP 2002582235A JP 2004533826 A5 JP2004533826 A5 JP 2004533826A5
- Authority
- JP
- Japan
- Prior art keywords
- primate
- polypeptide
- drug
- transgene
- construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000288906 Primates Species 0.000 description 49
- 229920001184 polypeptide Polymers 0.000 description 41
- 108090000765 processed proteins & peptides Proteins 0.000 description 41
- 102000004196 processed proteins & peptides Human genes 0.000 description 41
- 239000003814 drug Substances 0.000 description 25
- 229940079593 drug Drugs 0.000 description 25
- 230000009261 transgenic effect Effects 0.000 description 21
- 241000124008 Mammalia Species 0.000 description 18
- 108700019146 Transgenes Proteins 0.000 description 17
- 108090000623 proteins and genes Proteins 0.000 description 14
- 238000000034 method Methods 0.000 description 11
- 230000004060 metabolic process Effects 0.000 description 8
- 239000002773 nucleotide Substances 0.000 description 7
- 125000003729 nucleotide group Chemical group 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 150000007523 nucleic acids Chemical class 0.000 description 6
- 108700028369 Alleles Proteins 0.000 description 5
- 102000040430 polynucleotide Human genes 0.000 description 5
- 108091033319 polynucleotide Proteins 0.000 description 5
- 239000002157 polynucleotide Substances 0.000 description 5
- 230000006801 homologous recombination Effects 0.000 description 4
- 238000002744 homologous recombination Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 2
- 230000006798 recombination Effects 0.000 description 2
- 238000005215 recombination Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- VMSLCPKYRPDHLN-UHFFFAOYSA-N (R)-Humulone Chemical compound CC(C)CC(=O)C1=C(O)C(CC=C(C)C)=C(O)C(O)(CC=C(C)C)C1=O VMSLCPKYRPDHLN-UHFFFAOYSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 241000507627 Salana Species 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012854 evaluation process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR4467A AUPR446701A0 (en) | 2001-04-18 | 2001-04-18 | Transgenic mammals for pharmacological and toxicological studies |
| PCT/AU2002/000485 WO2002083897A1 (en) | 2001-04-18 | 2002-04-18 | Transgenic non-human animals for pharmacological and toxicological studies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008233283A Division JP2009055911A (ja) | 2001-04-18 | 2008-09-11 | 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004533826A JP2004533826A (ja) | 2004-11-11 |
| JP2004533826A5 true JP2004533826A5 (https=) | 2008-06-05 |
Family
ID=3828463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582235A Pending JP2004533826A (ja) | 2001-04-18 | 2002-04-18 | 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物 |
| JP2008233283A Pending JP2009055911A (ja) | 2001-04-18 | 2008-09-11 | 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008233283A Pending JP2009055911A (ja) | 2001-04-18 | 2008-09-11 | 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7544854B2 (https=) |
| EP (3) | EP1390500A4 (https=) |
| JP (2) | JP2004533826A (https=) |
| KR (1) | KR20040015711A (https=) |
| CN (1) | CN1518596A (https=) |
| AU (2) | AUPR446701A0 (https=) |
| CA (1) | CA2444451C (https=) |
| IL (2) | IL158457A0 (https=) |
| NZ (1) | NZ528948A (https=) |
| WO (1) | WO2002083897A1 (https=) |
| ZA (1) | ZA200308062B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP362898A0 (en) | 1998-05-21 | 1998-06-11 | University Of Sydney, The | Xenobiotic induction of gene expression |
| AUPR116100A0 (en) | 2000-11-01 | 2000-11-23 | University Of Sydney, The | P450 gene regulation |
| JP2005510205A (ja) | 2001-04-12 | 2005-04-21 | ゼノジェン コーポレイション | チトクロム発現に関連するマウスおよびヒト転写制御エレメントの単離および同定 |
| US6949691B2 (en) * | 2001-06-15 | 2005-09-27 | New Century Pharmaceuticals Inc. | Human albumin animal models for drug evaluation, toxicology and immunogenicity studies |
| US7504492B2 (en) | 2003-02-19 | 2009-03-17 | Hiroyuki Ueno | RNA polymerase III promoter, process for producing the same and method of using the same |
| DE10345837A1 (de) * | 2003-10-02 | 2005-04-21 | Bayer Technology Services Gmbh | Verfahren zur Bestimmung einer Wirkstoffdosierung |
| WO2006064197A2 (en) * | 2004-12-13 | 2006-06-22 | Iti Scotland Limited | Transgenic animals for assessing drug metabolism and toxicity |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| WO2007005604A2 (en) * | 2005-07-05 | 2007-01-11 | The Regents Of The University Of California | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof |
| AU2008322038B2 (en) * | 2007-11-14 | 2012-02-23 | National University Corporation Tottori University | Mammalian artificial chromosome vector comprising human cytochrome P450 gene (cluster) and non-human mammalian animal retaining the same |
| KR101722961B1 (ko) | 2009-02-11 | 2017-04-04 | 알부메딕스 에이/에스 | 알부민 변이체 및 접합체 |
| DK3622815T3 (da) * | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| EP2493921B1 (en) | 2009-10-30 | 2018-09-26 | Albumedix Ltd | Albumin variants |
| EP2556087A1 (en) | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
| CA2848417C (en) * | 2011-09-21 | 2023-05-02 | Sangamo Biosciences, Inc. | Methods and compositions for regulation of transgene expression |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| DK2825556T3 (en) | 2012-03-16 | 2018-04-16 | Albumedix As | albumin Variants |
| JP5976380B2 (ja) | 2012-04-27 | 2016-08-23 | 公益財団法人東京都医学総合研究所 | ウロキナーゼ型プラスミノーゲンアクチベータートランスジェニックマウス |
| MX2015005363A (es) | 2012-11-08 | 2015-11-06 | Novozymes Biopharma Dk As | Variantes de albumina. |
| JP6267986B2 (ja) * | 2014-02-13 | 2018-01-24 | 株式会社特殊免疫研究所 | ヒトの特定分子と結合する分子標的物質のｉｎｖｉｖｏ評価法 |
| JP7007261B2 (ja) | 2015-08-20 | 2022-01-24 | アルブミディクス リミティド | アルブミン変異体及びコンジュゲート |
| WO2017041020A1 (en) * | 2015-09-04 | 2017-03-09 | Oregon State University | Renal selective inhibition of cytochrome p450 3a5 |
| WO2017127414A1 (en) | 2016-01-19 | 2017-07-27 | Celgene Corporation | Transgenic mouse expressing human cereblon |
| CN106947816B (zh) * | 2016-10-28 | 2020-08-04 | 中山大学 | 一种斜带石斑鱼亲子鉴定微卫星荧光多重pcr的方法 |
| WO2018085967A1 (en) * | 2016-11-08 | 2018-05-17 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Genetically humanized mammals expressing human serum albumin and uses thereof |
| CN108977526A (zh) * | 2018-06-26 | 2018-12-11 | 苏州道尔盾基因科技有限公司 | 一种他克莫司和环孢素a个体化用药相关snp位点的检测方法及试剂盒 |
| CN114107385A (zh) * | 2019-01-17 | 2022-03-01 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| MX2021015122A (es) * | 2019-06-07 | 2022-04-06 | Regeneron Pharma | Animales no humanos que comprenden un locus de albumina humanizado. |
| CN111899791B (zh) * | 2020-06-17 | 2023-11-24 | 昆明理工大学 | 一种基于基因序列相似的病毒源头筛选方法 |
| CN114516910B (zh) * | 2020-11-19 | 2023-11-03 | 上海茵普森生物医药科技有限公司 | 一种用于治疗肥胖相关脂肪肝的蛋白质 |
| CN113337540B (zh) * | 2021-05-13 | 2022-06-14 | 武汉大学 | 特异性敲除小鼠Treg细胞中Notch2基因的模型构建方法 |
| WO2023019093A2 (en) * | 2021-08-07 | 2023-02-16 | Venn Biosciences Corporation | Detection of peptide structures for diagnosing and treating sepsis and covid |
| CN114569731B (zh) * | 2022-03-01 | 2023-05-05 | 山东大学 | 一种分子信标修饰的纳米载体及在制备抗肿瘤产品中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4994384A (en) * | 1986-12-31 | 1991-02-19 | W. R. Grace & Co.-Conn. | Multiplying bovine embryos |
| US5057420A (en) * | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5648597A (en) * | 1990-04-20 | 1997-07-15 | University Of South Carolina | Alpha-1-acid glycoprotein transgenic mice |
| AU649066B2 (en) | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| DE69133557D1 (de) * | 1990-08-29 | 2007-03-15 | Pharming Intellectual Pty Bv | Homologe rekombination in säugetier-zellen |
| WO1992015694A1 (en) * | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
| EP0597010A4 (en) | 1991-07-31 | 1996-12-27 | Rhone Poulenc Rorer Int | Transgenic protein production. |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| DK0862656T3 (da) | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
| JP2000506375A (ja) * | 1996-01-26 | 2000-05-30 | エイチエスシー リサーチ アンド デベロップメント リミテッド パートナーシップ | アルツハイマー病に関連する核酸およびタンパク質、ならびにその使用 |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US6271436B1 (en) | 1996-10-11 | 2001-08-07 | The Texas A & M University System | Cells and methods for the generation of transgenic pigs |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US6011197A (en) * | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
| JP2001519145A (ja) | 1997-10-02 | 2001-10-23 | イムクローン システムズ インコーポレーテッド | ノックインｖｅｃレセプター遺伝子を有するトランスジェニック動物及びその使用 |
| CA2317809A1 (en) | 1998-01-08 | 1999-07-15 | Daiichi Pharmaceutical Co., Ltd. | Gene mutant animals |
| US6258998B1 (en) | 1998-11-24 | 2001-07-10 | Infigen, Inc. | Method of cloning porcine animals |
| JP2001017028A (ja) | 1999-05-06 | 2001-01-23 | Mitsubishi Chemicals Corp | アポｅヒト化哺乳動物 |
| WO2001011951A1 (fr) * | 1999-08-13 | 2001-02-22 | Kirin Beer Kabushiki Kaisha | Souris renfermant un cytochrome p450 humain |
| WO2002017856A2 (en) * | 2000-08-29 | 2002-03-07 | Vanderbilt University | Compositions and methods relating to hypertension |
| AU9119201A (en) * | 2000-09-21 | 2002-04-02 | Baylor College Medicine | Screening systems and methods for identifying modulators of xenobiotic metabolism |
| US6949691B2 (en) | 2001-06-15 | 2005-09-27 | New Century Pharmaceuticals Inc. | Human albumin animal models for drug evaluation, toxicology and immunogenicity studies |
-
2001
- 2001-04-18 AU AUPR4467A patent/AUPR446701A0/en not_active Abandoned
-
2002
- 2002-04-18 EP EP02717850A patent/EP1390500A4/en not_active Ceased
- 2002-04-18 NZ NZ528948A patent/NZ528948A/en not_active IP Right Cessation
- 2002-04-18 WO PCT/AU2002/000485 patent/WO2002083897A1/en not_active Ceased
- 2002-04-18 US US10/475,069 patent/US7544854B2/en not_active Expired - Fee Related
- 2002-04-18 KR KR10-2003-7013684A patent/KR20040015711A/ko not_active Ceased
- 2002-04-18 JP JP2002582235A patent/JP2004533826A/ja active Pending
- 2002-04-18 EP EP10011058A patent/EP2316959A3/en not_active Withdrawn
- 2002-04-18 EP EP10011057A patent/EP2336338A3/en not_active Withdrawn
- 2002-04-18 CN CNA028121236A patent/CN1518596A/zh active Pending
- 2002-04-18 CA CA2444451A patent/CA2444451C/en not_active Expired - Fee Related
- 2002-04-18 AU AU2002248977A patent/AU2002248977C1/en not_active Ceased
- 2002-04-18 IL IL15845702A patent/IL158457A0/xx unknown
-
2003
- 2003-10-16 IL IL158457A patent/IL158457A/en not_active IP Right Cessation
- 2003-10-16 ZA ZA200308062A patent/ZA200308062B/en unknown
-
2008
- 2008-09-11 JP JP2008233283A patent/JP2009055911A/ja active Pending
-
2009
- 2009-04-13 US US12/422,938 patent/US7781643B2/en not_active Expired - Fee Related
-
2010
- 2010-08-20 US US12/860,797 patent/US8148599B2/en not_active Expired - Fee Related
-
2012
- 2012-03-09 US US13/416,886 patent/US8524975B2/en not_active Expired - Fee Related
-
2013
- 2013-08-30 US US14/015,755 patent/US9497944B2/en not_active Expired - Fee Related
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