AUPR446701A0 - Transgenic mammals for pharmacological and toxicological studies - Google Patents

Transgenic mammals for pharmacological and toxicological studies

Info

Publication number
AUPR446701A0
AUPR446701A0 AUPR4467A AUPR446701A AUPR446701A0 AU PR446701 A0 AUPR446701 A0 AU PR446701A0 AU PR4467 A AUPR4467 A AU PR4467A AU PR446701 A AUPR446701 A AU PR446701A AU PR446701 A0 AUPR446701 A0 AU PR446701A0
Authority
AU
Australia
Prior art keywords
pharmacological
transgenic mammals
toxicological studies
toxicological
studies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AUPR4467A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gene Stream Pty Ltd
Original Assignee
Gene Stream Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Stream Pty Ltd filed Critical Gene Stream Pty Ltd
Priority to AUPR4467A priority Critical patent/AUPR446701A0/en
Publication of AUPR446701A0 publication Critical patent/AUPR446701A0/en
Assigned to GENE STREAM PTY LTD reassignment GENE STREAM PTY LTD Assignment by Applicant under S 113 Assignors: DALY, JOHN MICHAEL
Priority to US10/475,069 priority patent/US7544854B2/en
Priority to KR10-2003-7013684A priority patent/KR20040015711A/ko
Priority to EP02717850A priority patent/EP1390500A4/en
Priority to CA2444451A priority patent/CA2444451C/en
Priority to PCT/AU2002/000485 priority patent/WO2002083897A1/en
Priority to EP10011057A priority patent/EP2336338A3/en
Priority to NZ528948A priority patent/NZ528948A/en
Priority to EP10011058A priority patent/EP2316959A3/en
Priority to IL15845702A priority patent/IL158457A0/xx
Priority to AU2002248977A priority patent/AU2002248977C1/en
Priority to JP2002582235A priority patent/JP2004533826A/ja
Priority to CNA028121236A priority patent/CN1518596A/zh
Priority to ZA200308062A priority patent/ZA200308062B/en
Priority to IL158457A priority patent/IL158457A/en
Priority to JP2008233283A priority patent/JP2009055911A/ja
Priority to US12/422,938 priority patent/US7781643B2/en
Priority to US12/860,797 priority patent/US8148599B2/en
Priority to US13/416,886 priority patent/US8524975B2/en
Priority to US14/015,755 priority patent/US9497944B2/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AUPR4467A 2001-04-18 2001-04-18 Transgenic mammals for pharmacological and toxicological studies Abandoned AUPR446701A0 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
AUPR4467A AUPR446701A0 (en) 2001-04-18 2001-04-18 Transgenic mammals for pharmacological and toxicological studies
JP2002582235A JP2004533826A (ja) 2001-04-18 2002-04-18 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物
CNA028121236A CN1518596A (zh) 2001-04-18 2002-04-18 用于药理学和毒理学研究的转基因非人动物
IL15845702A IL158457A0 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
AU2002248977A AU2002248977C1 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
EP02717850A EP1390500A4 (en) 2001-04-18 2002-04-18 TRANSGENIC ANIMALS FOR PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES
CA2444451A CA2444451C (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
PCT/AU2002/000485 WO2002083897A1 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
EP10011057A EP2336338A3 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
NZ528948A NZ528948A (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
EP10011058A EP2316959A3 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
US10/475,069 US7544854B2 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies
KR10-2003-7013684A KR20040015711A (ko) 2001-04-18 2002-04-18 약물학적 및 독성학적 연구용 트랜스제닉 비인간 동물
IL158457A IL158457A (en) 2001-04-18 2003-10-16 Transgenic non - primate mammals for use in predicting the likely behavior of a drug in a selected species of primate
ZA200308062A ZA200308062B (en) 2001-04-18 2003-10-16 Transgenic non-human animals for pharmacological and toxicological studies.
JP2008233283A JP2009055911A (ja) 2001-04-18 2008-09-11 薬理学的及び毒性学的研究のための非ヒトトランスジェニック動物
US12/422,938 US7781643B2 (en) 2001-04-18 2009-04-13 Transgenic non-human animals for pharmacological and toxicological studies
US12/860,797 US8148599B2 (en) 2001-04-18 2010-08-20 Transgenic non-human animals for pharmacological and toxicological studies
US13/416,886 US8524975B2 (en) 2001-04-18 2012-03-09 Method of predicting a behavior of one or more drugs
US14/015,755 US9497944B2 (en) 2001-04-18 2013-08-30 Mouse for predicting a behavior of drugs in humans

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPR4467A AUPR446701A0 (en) 2001-04-18 2001-04-18 Transgenic mammals for pharmacological and toxicological studies

Publications (1)

Publication Number Publication Date
AUPR446701A0 true AUPR446701A0 (en) 2001-05-17

Family

ID=3828463

Family Applications (2)

Application Number Title Priority Date Filing Date
AUPR4467A Abandoned AUPR446701A0 (en) 2001-04-18 2001-04-18 Transgenic mammals for pharmacological and toxicological studies
AU2002248977A Ceased AU2002248977C1 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2002248977A Ceased AU2002248977C1 (en) 2001-04-18 2002-04-18 Transgenic non-human animals for pharmacological and toxicological studies

Country Status (11)

Country Link
US (5) US7544854B2 (https=)
EP (3) EP2336338A3 (https=)
JP (2) JP2004533826A (https=)
KR (1) KR20040015711A (https=)
CN (1) CN1518596A (https=)
AU (2) AUPR446701A0 (https=)
CA (1) CA2444451C (https=)
IL (2) IL158457A0 (https=)
NZ (1) NZ528948A (https=)
WO (1) WO2002083897A1 (https=)
ZA (1) ZA200308062B (https=)

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CN111899791A (zh) * 2020-06-17 2020-11-06 昆明理工大学 一种基于基因序列相似的病毒源头筛选方法

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AUPR116100A0 (en) 2000-11-01 2000-11-23 University Of Sydney, The P450 gene regulation
US7449567B2 (en) 2001-04-12 2008-11-11 Xenogen Corporation Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
EP1406917A4 (en) * 2001-06-15 2007-11-14 New Century Pharmaceuticals HUMAN ANALYTICAL MODELS FOR THE EVALUATION OF MEDICINAL PRODUCTS AND FOR TOXICOLOGICAL AND IMMUNOGENIC EXAMINATIONS
WO2004074474A1 (ja) * 2003-02-19 2004-09-02 Shigeki Higashiyama 新規rnaポリメラーゼiiiプロモーター及びその製造方法並びにその使用方法
DE10345837A1 (de) * 2003-10-02 2005-04-21 Bayer Technology Services Gmbh Verfahren zur Bestimmung einer Wirkstoffdosierung
AU2005315438B2 (en) * 2004-12-13 2012-02-23 Iti Scotland Limited Transgenic animals for assessing drug metabolism and toxicity
US7759541B2 (en) 2004-12-13 2010-07-20 Iti Life Sciences Transgenic animals for assessing drug metabolism and toxicity
CN101495499B (zh) * 2005-07-05 2013-09-04 加利福尼亚大学董事会 编码类异戊烯修饰酶的多核苷酸和其使用方法
WO2009063722A1 (ja) * 2007-11-14 2009-05-22 National University Corporation Tottori University ヒトチトクロームp450遺伝子（クラスター）を含む哺乳動物人工染色体ベクター及びそれを保持する非ヒト哺乳動物
KR101722961B1 (ko) 2009-02-11 2017-04-04 알부메딕스 에이/에스 알부민 변이체 및 접합체
BR112012000536A2 (pt) * 2009-07-08 2020-08-11 Kymab Limited métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico
CA2776241A1 (en) 2009-10-30 2011-05-05 Novozymes Biopharma Dk A/S Albumin variants
US10233228B2 (en) 2010-04-09 2019-03-19 Albumedix Ltd Albumin derivatives and variants
AU2012312260B2 (en) * 2011-09-21 2017-08-31 Sangamo Therapeutics, Inc. Methods and compositions for regulation of transgene expression
EP2780364A2 (en) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteins with improved half-life and other properties
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JP5976380B2 (ja) * 2012-04-27 2016-08-23 公益財団法人東京都医学総合研究所 ウロキナーゼ型プラスミノーゲンアクチベータートランスジェニックマウス
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JP6267986B2 (ja) * 2014-02-13 2018-01-24 株式会社特殊免疫研究所 ヒトの特定分子と結合する分子標的物質のｉｎｖｉｖｏ評価法
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US11963520B2 (en) 2016-01-19 2024-04-23 Celgene Corporation Transgenic mouse expressing human cereblon
CN106947816B (zh) * 2016-10-28 2020-08-04 中山大学 一种斜带石斑鱼亲子鉴定微卫星荧光多重pcr的方法
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CN108977526A (zh) * 2018-06-26 2018-12-11 苏州道尔盾基因科技有限公司 一种他克莫司和环孢素a个体化用药相关snp位点的检测方法及试剂盒
WO2020147829A1 (zh) * 2019-01-17 2020-07-23 北京百奥赛图基因生物技术有限公司 人源化转基因动物
US11622547B2 (en) 2019-06-07 2023-04-11 Regeneran Pharmaceuticals, Inc. Genetically modified mouse that expresses human albumin
CN114516910B (zh) * 2020-11-19 2023-11-03 上海茵普森生物医药科技有限公司 一种用于治疗肥胖相关脂肪肝的蛋白质
CN113337540B (zh) * 2021-05-13 2022-06-14 武汉大学 特异性敲除小鼠Treg细胞中Notch2基因的模型构建方法
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CN114569731B (zh) * 2022-03-01 2023-05-05 山东大学 一种分子信标修饰的纳米载体及在制备抗肿瘤产品中的应用

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