JP2004531510A - ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法 - Google Patents
ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法 Download PDFInfo
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- JP2004531510A JP2004531510A JP2002578935A JP2002578935A JP2004531510A JP 2004531510 A JP2004531510 A JP 2004531510A JP 2002578935 A JP2002578935 A JP 2002578935A JP 2002578935 A JP2002578935 A JP 2002578935A JP 2004531510 A JP2004531510 A JP 2004531510A
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- msh
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- hydrogen
- melanocortin
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- Animal Behavior & Ethology (AREA)
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| GBGB0108631.3A GB0108631D0 (en) | 2001-04-05 | 2001-04-05 | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| PCT/GB2002/001589 WO2002080896A1 (en) | 2001-04-05 | 2002-04-05 | Uses of benzylideneamino guanidines as ligands to the melanocortiin receptors |
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| JP2004531510A true JP2004531510A (ja) | 2004-10-14 |
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| JP2002578935A Withdrawn JP2004531510A (ja) | 2001-04-05 | 2002-04-05 | ベンジリデンアミノグアニジンの、メラノコルチンレセプターリガンドとしての使用方法 |
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| EP (2) | EP1372625A1 (enExample) |
| JP (2) | JP2004531516A (enExample) |
| KR (2) | KR20030092045A (enExample) |
| BR (2) | BR0208657A (enExample) |
| CA (2) | CA2443099A1 (enExample) |
| GB (1) | GB0108631D0 (enExample) |
| IL (2) | IL158247A0 (enExample) |
| MX (2) | MXPA03008972A (enExample) |
| WO (2) | WO2002080896A1 (enExample) |
| ZA (1) | ZA200307453B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513258A (ja) * | 2006-12-14 | 2010-04-30 | アキュア ファーマ エービー | メラノコルチン受容体リガンドとしての新規アミノグアニジン |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| GB0119172D0 (en) * | 2001-08-06 | 2001-09-26 | Melacure Therapeutics Ab | Phenyl pyrrole derivatives |
| ATE482238T1 (de) | 2003-01-23 | 2010-10-15 | Kuraray Co | Polyvinylacetal und dessen verwendung |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2045250A1 (en) * | 2007-09-26 | 2009-04-08 | Action Pharma A/S | Ring-substituted phenyl pyrrole aminoguanidine derivatives |
| WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CN102271509A (zh) | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
| JP5514831B2 (ja) | 2008-11-17 | 2014-06-04 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病の治療のための置換二環式アミン |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| CA2768577A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8785634B2 (en) | 2010-04-26 | 2014-07-22 | Merck Sharp & Dohme Corp | Spiropiperidine prolylcarboxypeptidase inhibitors |
| EP2568812B1 (en) | 2010-05-11 | 2016-10-26 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| EP2579873A4 (en) | 2010-06-11 | 2013-11-27 | Merck Sharp & Dohme | NOVEL PROLYLCARBOXYPEPTIDASE HEMMER |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| KR101668514B1 (ko) | 2011-02-25 | 2016-10-21 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병제로서 유용한 신규 시클릭 아자벤즈이미다졸 유도체 |
| EP2880028B1 (en) | 2012-08-02 | 2020-09-30 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| CN104994848A (zh) | 2013-02-22 | 2015-10-21 | 默沙东公司 | 抗糖尿病二环化合物 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP3004138B1 (en) | 2013-06-05 | 2024-03-13 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| MX2016016480A (es) * | 2014-07-02 | 2017-08-02 | Inflectis Bioscience | Nuevos usos terapeuticos de derivados de bencilidenguanidina para el tratamiento de proteopatias. |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
| US20180230105A1 (en) | 2017-01-13 | 2018-08-16 | Regents Of The University Of Minnesota | Therapeutic compounds |
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| US2584784A (en) * | 1949-05-21 | 1952-02-05 | Du Pont | Salts of 1-salicylalaminoguanidine |
| DE1165013B (de) * | 1960-08-09 | 1964-03-12 | Vismara Francesco Spa | Verfahren zur Herstellung von Guanylhydrazonen |
| GB1223492A (en) * | 1967-10-13 | 1971-02-24 | American Home Prod | Guanidines |
| US3592935A (en) * | 1969-12-11 | 1971-07-13 | Sandoz Ag | Substituted benzylidene hydrazines as anti-inflammatory agents |
| US3982020A (en) * | 1970-03-17 | 1976-09-21 | Sandoz, Inc. | Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation |
| US4060640A (en) * | 1970-04-29 | 1977-11-29 | Shell Oil Company | Therapeutic agents |
| US3816531A (en) * | 1970-07-01 | 1974-06-11 | American Home Prod | (2,6-disubstituted benzylidene)amino guanidines and related compounds |
| US3896232A (en) * | 1973-01-11 | 1975-07-22 | Sandoz Ag | Substituted benzylidene hydrazines as anti-migraine syndrome agents |
| US3941825A (en) * | 1973-07-27 | 1976-03-02 | American Cyanamid Company | Substituted aminobenzylideneamino guanidine compounds |
| US4006250A (en) * | 1975-08-25 | 1977-02-01 | American Home Products Corporation | Systemic treatment of psoriasis |
| CA2113817A1 (en) * | 1991-08-27 | 1993-02-04 | Jerry R. Colca | A method for treatment of metabolic disorders |
| US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| SE9604348D0 (sv) * | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| AU6528400A (en) * | 1999-08-23 | 2001-03-19 | David M. Ockert | Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms |
| AU7802700A (en) * | 1999-10-06 | 2001-05-10 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513258A (ja) * | 2006-12-14 | 2010-04-30 | アキュア ファーマ エービー | メラノコルチン受容体リガンドとしての新規アミノグアニジン |
Also Published As
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| CA2443099A1 (en) | 2002-10-17 |
| BR0208658A (pt) | 2004-03-02 |
| JP2004531516A (ja) | 2004-10-14 |
| WO2002080896A1 (en) | 2002-10-17 |
| GB0108631D0 (en) | 2001-05-30 |
| EP1372625A1 (en) | 2004-01-02 |
| IL158248A0 (en) | 2004-05-12 |
| BR0208657A (pt) | 2004-03-02 |
| CA2443057A1 (en) | 2002-10-17 |
| WO2002081430A3 (en) | 2003-08-14 |
| WO2002081430A2 (en) | 2002-10-17 |
| US20040106683A1 (en) | 2004-06-03 |
| MXPA03008973A (es) | 2004-02-12 |
| KR20030088056A (ko) | 2003-11-15 |
| US20040106682A1 (en) | 2004-06-03 |
| KR20030092045A (ko) | 2003-12-03 |
| ZA200307453B (en) | 2004-09-27 |
| IL158247A0 (en) | 2004-05-12 |
| EP1383740A2 (en) | 2004-01-28 |
| MXPA03008972A (es) | 2004-02-12 |
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