JP2004531479A5 - - Google Patents
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- Publication number
- JP2004531479A5 JP2004531479A5 JP2002563134A JP2002563134A JP2004531479A5 JP 2004531479 A5 JP2004531479 A5 JP 2004531479A5 JP 2002563134 A JP2002563134 A JP 2002563134A JP 2002563134 A JP2002563134 A JP 2002563134A JP 2004531479 A5 JP2004531479 A5 JP 2004531479A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- hydrogen
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 125000001072 heteroaryl group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 150000002431 hydrogen Chemical group 0.000 claims description 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 4
- 239000011737 fluorine Chemical group 0.000 claims description 4
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical class 0.000 claims description 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0103175A GB0103175D0 (en) | 2001-02-08 | 2001-02-08 | Novel compounds |
| GB0105234A GB0105234D0 (en) | 2001-03-02 | 2001-03-02 | Novel compounds |
| PCT/EP2002/000957 WO2002062780A2 (en) | 2001-02-08 | 2002-01-30 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004531479A JP2004531479A (ja) | 2004-10-14 |
| JP2004531479A5 true JP2004531479A5 (enExample) | 2006-10-12 |
Family
ID=26245703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563134A Pending JP2004531479A (ja) | 2001-02-08 | 2002-01-30 | 甲状腺受容体リガンドとしてのフェノキシ置換されたベンゾ縮合ヘテロアリール誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7144909B2 (enExample) |
| EP (1) | EP1358175A2 (enExample) |
| JP (1) | JP2004531479A (enExample) |
| KR (1) | KR20030072396A (enExample) |
| AU (1) | AU2002237298B2 (enExample) |
| CA (1) | CA2435820A1 (enExample) |
| IL (1) | IL157031A0 (enExample) |
| WO (1) | WO2002062780A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0219022D0 (en) * | 2002-08-15 | 2002-09-25 | Karobio Ab | Novel thyromimetic compounds |
| TW200504021A (en) | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
| EP1689383B1 (en) | 2003-11-19 | 2012-10-31 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| CA2547212A1 (en) * | 2003-11-25 | 2005-06-16 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| KR20070083612A (ko) * | 2004-09-01 | 2007-08-24 | 트르스티스 오브 보스톤 유니버시티 | 갑상선 호르몬 전환 저해제의 용도 |
| US20090028925A1 (en) * | 2005-05-26 | 2009-01-29 | Erion Mark D | Novel Phosphinic Acid-Containing Thyromimetics |
| CA2606499C (en) | 2005-05-26 | 2017-06-13 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| GB0513692D0 (en) * | 2005-07-04 | 2005-08-10 | Karobio Ab | Novel pharmaceutical compositions |
| HRP20100633T1 (hr) * | 2005-07-21 | 2011-01-31 | F. Hoffmann - La Roche Ag | Derivati piridazinona kao agonisti receptora tiroidnih hormona |
| TW200804345A (en) * | 2005-08-30 | 2008-01-16 | Novartis Ag | Substituted benzimidazoles and methods of preparation |
| GB0608724D0 (en) * | 2006-05-03 | 2006-06-14 | Karobio Ab | Novel Pharmaceutical Compositions |
| GB0610322D0 (en) * | 2006-05-24 | 2006-07-05 | Karobio Ab | Novel pharmaceutical compositions |
| US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
| RU2469725C2 (ru) * | 2010-07-01 | 2012-12-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Тверская государственная медицинская академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО "Тверская ГМА" Минздравсоцразвития России) | Способ предоперационной подготовки больных тиреотоксикозом |
| CN102718718B (zh) * | 2012-05-31 | 2014-09-24 | 绍兴文理学院 | 一种3,5-二溴-4-（5-苯并咪唑氧基）苯乙酸的制备方法 |
| CA3044059A1 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| EA201992703A1 (ru) | 2017-06-05 | 2020-04-15 | Вайкинг Терапьютикс, Инк. | Композиции для лечения фиброза |
| CA3094167A1 (en) | 2018-03-22 | 2019-09-26 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| US6472387B1 (en) * | 1996-10-07 | 2002-10-29 | Eli Lilly And Company | Methods of using compounds as neuro-protective agents |
| ATE240728T1 (de) * | 1996-10-07 | 2003-06-15 | Lilly Co Eli | Neue verbindungen nutlich als neuroschützende mittel |
| GB9713739D0 (en) | 1997-06-27 | 1997-09-03 | Karobio Ab | Thyroid receptor ligands |
| GB9828442D0 (en) | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
| CA2403806A1 (en) | 2000-03-23 | 2002-09-20 | Bayer Aktiengesellschaft | Indoles for treating diseases that can be treated using thyroid hormones |
| CA2433100A1 (en) | 2000-12-27 | 2002-07-04 | Helmut Haning | Indole derivatives as ligands of thyroid receptors |
-
2002
- 2002-01-30 CA CA002435820A patent/CA2435820A1/en not_active Abandoned
- 2002-01-30 EP EP02703589A patent/EP1358175A2/en not_active Withdrawn
- 2002-01-30 AU AU2002237298A patent/AU2002237298B2/en not_active Ceased
- 2002-01-30 US US10/470,878 patent/US7144909B2/en not_active Expired - Fee Related
- 2002-01-30 WO PCT/EP2002/000957 patent/WO2002062780A2/en not_active Ceased
- 2002-01-30 KR KR10-2003-7010172A patent/KR20030072396A/ko not_active Withdrawn
- 2002-01-30 IL IL15703102A patent/IL157031A0/xx unknown
- 2002-01-30 JP JP2002563134A patent/JP2004531479A/ja active Pending
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