JP2004530125A - 多光子励起のための光学構造及びその使用 - Google Patents

多光子励起のための光学構造及びその使用 Download PDF

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Publication number
JP2004530125A
JP2004530125A JP2002577546A JP2002577546A JP2004530125A JP 2004530125 A JP2004530125 A JP 2004530125A JP 2002577546 A JP2002577546 A JP 2002577546A JP 2002577546 A JP2002577546 A JP 2002577546A JP 2004530125 A JP2004530125 A JP 2004530125A
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Prior art keywords
layer
excitation
optical
optical structure
excitation light
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JP2002577546A
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Japanese (ja)
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JP2004530125A5 (enExample
Inventor
ドゥフェネク，ゲルト・エル
ボップ，マルティン・アー
パウラク，ミヒャエル
エーラート，マルクス
マロースキー，ゲルト
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Zeptosens AG
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Zeptosens AG
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Publication of JP2004530125A publication Critical patent/JP2004530125A/ja
Publication of JP2004530125A5 publication Critical patent/JP2004530125A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7709—Distributed reagent, e.g. over length of guide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793—Sensor comprising plural indicators
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B2006/12083—Constructional arrangements
    • G02B2006/12107—Grating

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2002577546A 2001-04-02 2002-03-18 多光子励起のための光学構造及びその使用 Pending JP2004530125A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH6172001 2001-04-02
CH6892001 2001-04-12
PCT/EP2002/002958 WO2002079765A2 (de) 2001-04-02 2002-03-18 Optische struktur zur multi-photonen-anregung und deren verwendung

Publications (2)

Publication Number Publication Date
JP2004530125A true JP2004530125A (ja) 2004-09-30
JP2004530125A5 JP2004530125A5 (enExample) 2005-12-22

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JP2002577546A Pending JP2004530125A (ja) 2001-04-02 2002-03-18 多光子励起のための光学構造及びその使用

Country Status (5)

Country Link
US (1) US20040052489A1 (enExample)
EP (1) EP1373875A2 (enExample)
JP (1) JP2004530125A (enExample)
AU (1) AU2002257671A1 (enExample)
WO (1) WO2002079765A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006070941A1 (ja) * 2004-12-28 2006-07-06 Tokyo University Of Science 蛍光分子プローブを用いた新規薬剤スクリーニング方法
JP2009047540A (ja) * 2007-08-20 2009-03-05 Sony Corp レーザーを用いた生体物質検出方法
WO2013021984A1 (ja) * 2011-08-08 2013-02-14 オリンパス株式会社 共焦点顕微鏡又は多光子顕微鏡の光学系を用いた光分析装置及び光分析方法

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US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
FR2860886B1 (fr) * 2003-10-14 2005-12-23 Commissariat Energie Atomique Dispositif de deplacement de particules
FI20040236A0 (fi) * 2004-02-13 2004-02-13 Arctic Diagnostics Oy Kaksoisfotoniviritetyn Fluoresenssin käyttö kliinisen kemian analyyttien määrityksissä
US9050615B2 (en) 2005-04-26 2015-06-09 Bayer Intellectual Property Gmbh Apparatus and method for coating substrates for analyte detection by means of an affinity assay method
WO2006135782A2 (en) * 2005-06-10 2006-12-21 Applera Corporation Method and system for multiplex genetic analysis
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
CA2759396A1 (en) * 2009-04-29 2010-11-04 Plc Diagnostics Inc. Waveguide-based detection system with scanning light source
KR101440119B1 (ko) 2013-10-08 2014-09-12 한국원자력연구원 광섬유를 이용한 플라즈마 확산 속도 측정 장치 및 방법
CN103743712B (zh) * 2014-01-08 2016-06-08 石家庄经济学院 一种光释光剂量测定仪
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US9678015B2 (en) 2014-09-26 2017-06-13 Frito-Lay North America, Inc. Method for elemental analysis of a snack food product in a dynamic production line
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
US11243190B2 (en) 2015-09-24 2022-02-08 Frito-Lay North America, Inc. Quantitative liquid texture measurement method
US9541537B1 (en) 2015-09-24 2017-01-10 Frito-Lay North America, Inc. Quantitative texture measurement apparatus and method
US10969316B2 (en) 2015-09-24 2021-04-06 Frito-Lay North America, Inc. Quantitative in-situ texture measurement apparatus and method
US10598648B2 (en) 2015-09-24 2020-03-24 Frito-Lay North America, Inc. Quantitative texture measurement apparatus and method
US10107785B2 (en) 2015-09-24 2018-10-23 Frito-Lay North America, Inc. Quantitative liquid texture measurement apparatus and method
US10070661B2 (en) 2015-09-24 2018-09-11 Frito-Lay North America, Inc. Feedback control of food texture system and method
EP3403068B1 (en) * 2016-01-12 2019-11-06 Katholieke Universiteit Leuven KU Leuven Research & Development Method for detecting or quantifying carbon black and/or black carbon particles
RU2688949C1 (ru) 2018-08-24 2019-05-23 Самсунг Электроникс Ко., Лтд. Антенна миллиметрового диапазона и способ управления антенной
US11650361B2 (en) * 2018-12-27 2023-05-16 Viavi Solutions Inc. Optical filter
CN110455793B (zh) * 2019-08-29 2021-12-14 佛山市安齿生物科技有限公司 一种区分纯钛与钛合金的方法
US11579093B2 (en) * 2020-04-22 2023-02-14 SciLogica Corp. Optical component

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US3572941A (en) * 1967-12-07 1971-03-30 Rca Corp Photochromic device based upon photon absorption
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
PL317379A1 (en) * 1994-05-27 1997-04-01 Ciba Geigy Ag Supercritically excited luminescence detecting process
EP1190236A1 (de) * 1999-06-05 2002-03-27 Zeptosens AG Sensorplatform und verfahren zur multianalytbestimmung
PT1192448E (pt) * 1999-07-05 2007-01-31 Novartis Ag Processo para a utilização de uma plataforma de sensor
AU2001262178A1 (en) * 2000-04-14 2001-10-30 Zeptosens Ag Grid-waveguide structure for reinforcing an excitation field and use thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006070941A1 (ja) * 2004-12-28 2006-07-06 Tokyo University Of Science 蛍光分子プローブを用いた新規薬剤スクリーニング方法
JP5099675B2 (ja) * 2004-12-28 2012-12-19 学校法人東京理科大学 蛍光分子プローブを用いた新規薬剤スクリーニング方法
JP2009047540A (ja) * 2007-08-20 2009-03-05 Sony Corp レーザーを用いた生体物質検出方法
WO2013021984A1 (ja) * 2011-08-08 2013-02-14 オリンパス株式会社 共焦点顕微鏡又は多光子顕微鏡の光学系を用いた光分析装置及び光分析方法

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Publication number Publication date
EP1373875A2 (de) 2004-01-02
WO2002079765A3 (de) 2003-01-30
US20040052489A1 (en) 2004-03-18
WO2002079765A2 (de) 2002-10-10
AU2002257671A1 (en) 2002-10-15

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