JP2004528334A5 - - Google Patents
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- Publication number
- JP2004528334A5 JP2004528334A5 JP2002583393A JP2002583393A JP2004528334A5 JP 2004528334 A5 JP2004528334 A5 JP 2004528334A5 JP 2002583393 A JP2002583393 A JP 2002583393A JP 2002583393 A JP2002583393 A JP 2002583393A JP 2004528334 A5 JP2004528334 A5 JP 2004528334A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- moiety
- methyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 26
- -1 cyano, acetoxymethyl Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052757 nitrogen Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006690 (C2-C6) heterocyclyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 125000006479 2-pyridyl methyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 1
- 125000006224 2-tetrahydrofuranylmethyl group Chemical group [H]C([H])(*)C1([H])OC([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000000593 indol-1-yl group Chemical group [H]C1=C([H])C([H])=C2N([*])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Chemical group 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101387A SE0101387D0 (sv) | 2001-04-20 | 2001-04-20 | Novel compounds |
| PCT/SE2002/000769 WO2002085866A1 (en) | 2001-04-20 | 2002-04-18 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528334A JP2004528334A (ja) | 2004-09-16 |
| JP2004528334A5 true JP2004528334A5 (cg-RX-API-DMAC10.html) | 2005-12-22 |
Family
ID=20283822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002583393A Pending JP2004528334A (ja) | 2001-04-20 | 2002-04-18 | 新規な化合物 |
Country Status (25)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005533748A (ja) | 2002-03-08 | 2005-11-10 | シグナル ファーマシューティカルズ，インコーポレイテッド | 増殖性障害および癌を治療、予防、または管理するための併用療法 |
| SE0203070D0 (en) * | 2002-10-16 | 2002-10-16 | Astrazeneca Ab | Novel compounds |
| EP1608628A2 (en) * | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| SE0300908D0 (sv) * | 2003-03-31 | 2003-03-31 | Astrazeneca Ab | Azaindole derivatives, preparations thereof, uses thereof and compositions containing them |
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| SE0301699D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0301698D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0301701D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| WO2005000829A1 (ja) * | 2003-06-26 | 2005-01-06 | Takeda Pharmaceutical Company Limited | カンナビノイド受容体調節剤 |
| US7157471B2 (en) * | 2003-08-25 | 2007-01-02 | Boehringer Ingelheim International Gmbh | Haloalkyl- and piperidine-substituted benzimidazole-derivatives |
| WO2005021547A2 (en) * | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Heterocyclic cannabinoid cb2 receptor antagonists |
| SE0302570D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302573D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302572D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0302571D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| CA2539632A1 (en) * | 2003-10-16 | 2005-04-28 | Cara Therapeutics, Inc. | Amide or thioamide derivatives and their use in the treatment of pain |
| WO2006033627A1 (en) * | 2004-09-24 | 2006-03-30 | Astrazeneca Ab | Compounds, compositions containing them, preparation thereof and uses thereof iiii |
| EP1797075A1 (en) * | 2004-09-24 | 2007-06-20 | AstraZeneca AB | Benzimidazole derivatives and their use as cannabinoid receptor ligands |
| EP1794150A1 (en) * | 2004-09-24 | 2007-06-13 | AstraZeneca AB | Benzimidazole derivatives and their use as cannabinoid receptor ligands I |
| JP2008514592A (ja) * | 2004-09-24 | 2008-05-08 | アストラゼネカ・アクチエボラーグ | ベンゾイミダゾール誘導体、それらを含有する組成物、それらの製造及びそれらの使用ｉｉｉ |
| CN101052639B (zh) * | 2004-09-24 | 2010-10-27 | 阿斯利康(瑞典)有限公司 | 苯并咪唑衍生物、含有它们的组合物、其制备方法和其用途 |
| CA2581232C (en) * | 2004-09-24 | 2015-04-07 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof i |
| EP1797070A1 (en) * | 2004-09-24 | 2007-06-20 | AstraZeneca AB | Compounds, compositions containing them, preparations thereof and uses thereof ii |
| EP1797076A1 (en) * | 2004-09-24 | 2007-06-20 | AstraZeneca AB | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| BRPI0515897A (pt) | 2004-09-24 | 2008-08-12 | Astrazeneca Ab | composto, uso do mesmo, composição farmacêutica, e, método para a terapia de dor em um animal de sangue quente, e para a preparação de um composto |
| JP2008517959A (ja) | 2004-10-27 | 2008-05-29 | エフ．ホフマン−ラ ロシュ アーゲー | 新規なインドール又はベンゾイミダゾール誘導体 |
| ATE417830T1 (de) * | 2004-11-02 | 2009-01-15 | Pfizer | Sulfonylbenzimidazolderivate |
| SE0402763D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Nitro indazole derivatives |
| SE0402762D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Indazole sulphonamide derivatives |
| WO2006097808A1 (en) * | 2005-03-15 | 2006-09-21 | Pfizer Japan Inc. | Benzimidazolone derivatives as cb2 receptor ligands |
| US20100261796A1 (en) | 2005-04-28 | 2010-10-14 | Ferring B.V. | Use of Novel Compounds for IBD Treatment |
| TW200736227A (en) | 2005-12-23 | 2007-10-01 | Astrazeneca Ab | New compounds III |
| WO2007091950A1 (en) * | 2006-02-07 | 2007-08-16 | Astrazeneca Ab | Benzimidazoles and imidazopyridines useful in the treatment of diseases or disorders associated with cannabinoid receptor 2 (cb2) such as pain |
| US7700618B2 (en) | 2006-03-06 | 2010-04-20 | Pfizer Inc | Sulfonyl benzimidazole derivatives |
| TW200745049A (en) | 2006-03-23 | 2007-12-16 | Astrazeneca Ab | New crystalline forms |
| TW200808769A (en) | 2006-04-18 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| TW200808772A (en) * | 2006-06-13 | 2008-02-16 | Astrazeneca Ab | Therapeutic compounds |
| AU2007271241A1 (en) * | 2006-07-04 | 2008-01-10 | Janssen Pharmaceutica Nv | Benzimidazole cannabinoid agonists bearing a substituted heterocyclic group |
| TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| FR2907784B1 (fr) * | 2006-10-27 | 2009-02-13 | Sod Conseils Rech Applic | Derives phenyliques et leur utilisation comme medicament |
| WO2009116074A2 (en) * | 2008-02-13 | 2009-09-24 | Cadila Healthcare Limited | Substituted benzimidazoles as cannabinoid modulator |
| US20120277296A1 (en) | 2009-07-23 | 2012-11-01 | Sophie Lotersztajn | Selective CB2 Receptor Agonists for Use in the Prevention or Treatment of Alcoholic Liver Disease |
| US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| KR101837759B1 (ko) | 2010-02-18 | 2018-04-26 | 브이티브이 테라퓨틱스 엘엘씨 | 치환된 융합 이미다졸 유도체, 약학적 조성물, 및 그것의 사용 방법 |
| AU2012284184B2 (en) | 2011-07-18 | 2017-03-09 | Merck Patent Gmbh | Benzamides |
| CN102977056B (zh) * | 2012-11-28 | 2014-11-26 | 深圳万乐药业有限公司 | N-苄氧羰基-3-氟-4-吗啉基苯胺的合成方法 |
| WO2016089648A1 (en) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof |
| WO2017157332A1 (zh) * | 2016-03-18 | 2017-09-21 | 江苏恒瑞医药股份有限公司 | 芳香酰胺类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2945044A (en) * | 1957-07-12 | 1960-07-12 | Ciba Pharm Prod Inc | Certain 1-(diethyl-aminoethyl), 5-amino, 2-benzyl or substituted benzyl, benzimidazoles |
| FR1481049A (fr) | 1965-11-25 | 1967-05-19 | France Ministre Des Armees | Nouveaux dialkylaminoalkyl-1 p-alkoxyphényl alkyl-2 benzimidazoles 5-substitués |
| IL112235A (en) * | 1994-01-03 | 2000-06-29 | Acea Pharm Inc | 1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them |
| CA2192206A1 (en) * | 1994-06-10 | 1995-12-21 | Bernhard Kohl | Thiopyridines for use in the control of helicobacter bacteria |
| SE0203070D0 (en) * | 2002-10-16 | 2002-10-16 | Astrazeneca Ab | Novel compounds |
-
2001
- 2001-04-20 SE SE0101387A patent/SE0101387D0/xx unknown
-
2002
- 2002-04-18 CN CNB028085779A patent/CN1250531C/zh not_active Expired - Fee Related
- 2002-04-18 NZ NZ528403A patent/NZ528403A/en unknown
- 2002-04-18 SK SK1303-2003A patent/SK13032003A3/sk not_active Application Discontinuation
- 2002-04-18 BR BR0208907-6A patent/BR0208907A/pt not_active IP Right Cessation
- 2002-04-18 CA CA002444381A patent/CA2444381A1/en not_active Abandoned
- 2002-04-18 WO PCT/SE2002/000769 patent/WO2002085866A1/en not_active Ceased
- 2002-04-18 MY MYPI20021423A patent/MY134568A/en unknown
- 2002-04-18 HU HU0303825A patent/HUP0303825A3/hu unknown
- 2002-04-18 RU RU2003129638/04A patent/RU2312864C2/ru not_active IP Right Cessation
- 2002-04-18 US US10/474,549 patent/US7030139B2/en not_active Expired - Fee Related
- 2002-04-18 UA UA2003108942A patent/UA76743C2/uk unknown
- 2002-04-18 KR KR10-2003-7013622A patent/KR20040022421A/ko not_active Ceased
- 2002-04-18 EP EP02764120A patent/EP1390350A1/en not_active Withdrawn
- 2002-04-18 JP JP2002583393A patent/JP2004528334A/ja active Pending
- 2002-04-18 EE EEP200300524A patent/EE200300524A/xx unknown
- 2002-04-18 IL IL15814202A patent/IL158142A0/xx unknown
- 2002-04-18 PL PL02366517A patent/PL366517A1/xx not_active Application Discontinuation
- 2002-04-18 MX MXPA03009558A patent/MXPA03009558A/es active IP Right Grant
- 2002-04-18 CZ CZ20032833A patent/CZ20032833A3/cs unknown
- 2002-04-19 AR ARP020101441A patent/AR035959A1/es not_active Application Discontinuation
-
2003
- 2003-09-29 IS IS6971A patent/IS6971A/is unknown
- 2003-10-03 ZA ZA200307752A patent/ZA200307752B/en unknown
- 2003-10-14 BG BG108271A patent/BG108271A/bg unknown
- 2003-10-17 NO NO20034665A patent/NO20034665L/no not_active Application Discontinuation
-
2006
- 2006-01-04 US US11/325,124 patent/US20060135554A1/en not_active Abandoned