JP2004527524A - 非経口初回抗原刺激後の粘膜追加免疫 - Google Patents

非経口初回抗原刺激後の粘膜追加免疫 Download PDF

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JP2004527524A
JP2004527524A JP2002578702A JP2002578702A JP2004527524A JP 2004527524 A JP2004527524 A JP 2004527524A JP 2002578702 A JP2002578702 A JP 2002578702A JP 2002578702 A JP2002578702 A JP 2002578702A JP 2004527524 A JP2004527524 A JP 2004527524A
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virus
antigens
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immunogenic composition
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JP2004527524A5 (de
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デレック オーヘイガン,
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カイロン コーポレイション
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P37/02Immunomodulators
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
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    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • A61K2039/6093Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
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    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
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    • C12N2740/00Reverse transcribing RNA viruses
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    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002578702A 2001-04-05 2002-04-05 非経口初回抗原刺激後の粘膜追加免疫 Withdrawn JP2004527524A (ja)

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Application Number Priority Date Filing Date Title
US28238901P 2001-04-05 2001-04-05
PCT/US2002/010869 WO2002080648A2 (en) 2001-04-05 2002-04-05 Mucosal boosting following parenteral priming

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JP2009057158A Division JP2009120620A (ja) 2001-04-05 2009-03-10 非経口初回抗原刺激後の粘膜追加免疫

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JP2004527524A true JP2004527524A (ja) 2004-09-09
JP2004527524A5 JP2004527524A5 (de) 2005-12-22

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JP2002578702A Withdrawn JP2004527524A (ja) 2001-04-05 2002-04-05 非経口初回抗原刺激後の粘膜追加免疫
JP2009057158A Withdrawn JP2009120620A (ja) 2001-04-05 2009-03-10 非経口初回抗原刺激後の粘膜追加免疫
JP2012274421A Withdrawn JP2013053162A (ja) 2001-04-05 2012-12-17 非経口初回抗原刺激後の粘膜追加免疫

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JP2009057158A Withdrawn JP2009120620A (ja) 2001-04-05 2009-03-10 非経口初回抗原刺激後の粘膜追加免疫
JP2012274421A Withdrawn JP2013053162A (ja) 2001-04-05 2012-12-17 非経口初回抗原刺激後の粘膜追加免疫

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US (3) US20030072764A1 (de)
EP (1) EP1372528B1 (de)
JP (3) JP2004527524A (de)
CA (1) CA2439111A1 (de)
ES (1) ES2399386T3 (de)
WO (1) WO2002080648A2 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011525902A (ja) * 2008-06-25 2011-09-29 ノバルティス アーゲー 遅延型追加刺激免疫処置に対する迅速な応答
JP2016502995A (ja) * 2012-12-17 2016-02-01 ユーロシネ ヴァクシンズ アクチエボラーグ 鼻腔内予防接種投薬レジメン
WO2019235466A1 (ja) * 2018-06-05 2019-12-12 東興薬品工業株式会社 B型肝炎ワクチン経鼻投与システム

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326174D0 (en) * 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
US20060147466A1 (en) * 2002-05-14 2006-07-06 Chiron Srl Mucosal combination vaccines for bacterial meningitis
MXPA04011249A (es) * 2002-05-14 2005-06-06 Chiron Srl Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos.
GB0302218D0 (en) * 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
GB0300881D0 (en) * 2003-01-15 2003-02-12 Secr Defence Therapeutic treatment
RU2364419C2 (ru) * 2003-04-25 2009-08-20 Новартис Вэксинес Энд Дайэгностикс, Инк. Композиции, содержащие катионные микрочастицы и днк hcv е1е2, и способы их применения
PL1635863T3 (pl) * 2003-06-17 2011-01-31 Mannkind Corp Kompozycje do wywoływania, wzmacniania i utrzymywania odpowiedzi immunologicznych na epitopy ograniczone do MHC klasy I do celów profilaktycznych i leczniczych
CU23470A1 (es) * 2004-08-11 2009-12-17 Ct Ingenieria Genetica Biotech Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c
US20100285062A1 (en) * 2006-03-31 2010-11-11 Novartis Ag Combined mucosal and parenteral immunization against hiv
US20090105668A1 (en) * 2007-10-19 2009-04-23 Devon Monroe Feminine vaginal douche for tightening a vaginal orifice
GB0810305D0 (en) 2008-06-05 2008-07-09 Novartis Ag Influenza vaccination
AU2009262893B2 (en) * 2008-05-30 2015-05-21 The U.S.A., as represented by The Secretary of the Army, on behalf of Walter Reed Army Institute Of Research Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof
DK2310046T3 (da) 2008-06-27 2016-04-25 Zoetis Services Llc Hidtil ukendte adjuvanssammensætninger
CU20080215A7 (es) * 2008-11-19 2012-06-21 Inst Finlay Vacunas unitemporales
EP2742952A1 (de) 2012-12-17 2014-06-18 Eurocine Vaccines AB Impfstoffzusammensetzung
EP3046580A2 (de) 2013-09-19 2016-07-27 Zoetis Services LLC Adjuvanzien auf ölbasis
PT3244920T (pt) 2015-01-16 2023-07-28 Zoetis Services Llc Vacina contra a febre aftosa
EP3823668A1 (de) 2018-07-16 2021-05-26 DCPrime B.V. Kombinationsprodukt zur verwendung in der tumorimpfung
CA3133410A1 (en) 2019-04-25 2020-10-29 Dcprime B.V. Methods of tumor vaccination

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5462734A (en) * 1990-11-02 1995-10-31 Wisconsin Alumni Research Foundation Bovine herpesvirus vaccine and method of using same
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
US5679647A (en) * 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
MX9703676A (es) * 1994-11-17 1998-03-31 Maxim Pharm Inc Inmunogenos para estimular la inmunidad de las mucosas.
AU4369596A (en) * 1994-11-21 1996-06-17 Virginia L. Scofield Sperm as vaccine vectors
WO1997044446A1 (en) * 1996-05-24 1997-11-27 University Of Maryland At Baltimore Dna vaccines for eliciting a mucosal immune response
SE9602280D0 (sv) * 1996-06-10 1996-06-10 Pharmatrix Ab Immunstimulerande lipidformulering
DE69708318T3 (de) * 1996-08-27 2006-11-16 Novartis Vaccines and Diagnostics, Inc., Emeryville Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
EP1042001B1 (de) * 1997-12-16 2002-04-03 Chiron Corporation Verwendung von mikropartikeln mit submikron öl/wasser emulsionen
JP2002511423A (ja) * 1998-04-09 2002-04-16 スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム ワクチン
US6210663B1 (en) * 1998-08-20 2001-04-03 The Wistar Institute Of Anatomy And Biology Methods of augmenting mucosal immunity through systemic priming and mucosal boosting
DE60239317D1 (de) * 2001-01-12 2011-04-14 Novartis Vaccines & Diagnostic Nukleinsäure mukosale immunisierung
WO2002081655A2 (en) * 2001-03-28 2002-10-17 Children's Medical Center Corporation Fusion protein construct and method for inducing hiv-specific serum igg and secretory iga antibodies in-vivo

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011525902A (ja) * 2008-06-25 2011-09-29 ノバルティス アーゲー 遅延型追加刺激免疫処置に対する迅速な応答
JP2016502995A (ja) * 2012-12-17 2016-02-01 ユーロシネ ヴァクシンズ アクチエボラーグ 鼻腔内予防接種投薬レジメン
WO2019235466A1 (ja) * 2018-06-05 2019-12-12 東興薬品工業株式会社 B型肝炎ワクチン経鼻投与システム
JPWO2019235466A1 (ja) * 2018-06-05 2021-06-24 東興薬品工業株式会社 B型肝炎ワクチン経鼻投与システム
US12070497B2 (en) 2018-06-05 2024-08-27 Toko Yakuhin Kogyo Co., Ltd. Hepatitis B vaccine transnasal administration system

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WO2002080648A2 (en) 2002-10-17
JP2013053162A (ja) 2013-03-21
ES2399386T3 (es) 2013-04-01
US20030072764A1 (en) 2003-04-17
US20070196391A1 (en) 2007-08-23
JP2009120620A (ja) 2009-06-04
CA2439111A1 (en) 2002-10-17
WO2002080648A3 (en) 2002-11-28
EP1372528B1 (de) 2013-01-02
US20120171244A1 (en) 2012-07-05
EP1372528A2 (de) 2004-01-02
EP1372528A4 (de) 2005-03-16

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