JP2004525917A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004525917A5 JP2004525917A5 JP2002571091A JP2002571091A JP2004525917A5 JP 2004525917 A5 JP2004525917 A5 JP 2004525917A5 JP 2002571091 A JP2002571091 A JP 2002571091A JP 2002571091 A JP2002571091 A JP 2002571091A JP 2004525917 A5 JP2004525917 A5 JP 2004525917A5
- Authority
- JP
- Japan
- Prior art keywords
- mpr
- acetyl
- amino
- agent
- dermatan sulfate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- -1 sulfated N-acetyl-D-galactosamine disaccharide Chemical class 0.000 claims 6
- 229920000045 Dermatan sulfate Polymers 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 5
- 229940051593 dermatan sulfate Drugs 0.000 claims 5
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 4
- 101710149643 Integrin alpha-IIb Proteins 0.000 claims 4
- 239000002464 receptor antagonist Substances 0.000 claims 4
- 229940044551 receptor antagonist Drugs 0.000 claims 4
- 102000004032 Heparin Cofactor II Human genes 0.000 claims 3
- 108090000481 Heparin Cofactor II Proteins 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 229960003767 alanine Drugs 0.000 claims 3
- AEMOLEFTQBMNLQ-CLQWQSTFSA-N l-iduronic acid Chemical group O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O AEMOLEFTQBMNLQ-CLQWQSTFSA-N 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 108010056764 Eptifibatide Proteins 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- GLGOPUHVAZCPRB-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CN=C2[C]1C=CC=C2 GLGOPUHVAZCPRB-LROMGURASA-N 0.000 claims 1
- 229960004468 eptifibatide Drugs 0.000 claims 1
- VJDOPFARMOLELX-ZDUSSCGKSA-N ethyl 3-[[(3s)-1-(4-carbamimidoylphenyl)-2-oxopyrrolidin-3-yl]carbamoylamino]propanoate Chemical compound O=C1[C@@H](NC(=O)NCCC(=O)OCC)CCN1C1=CC=C(C(N)=N)C=C1 VJDOPFARMOLELX-ZDUSSCGKSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229950002383 orbofiban Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- YYFIGOPUHPDIBO-UHFFFAOYSA-N propanoic acid;hydrochloride Chemical compound Cl.CCC(O)=O YYFIGOPUHPDIBO-UHFFFAOYSA-N 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/802,775 US6518244B2 (en) | 2000-03-09 | 2001-03-09 | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
| PCT/US2002/006969 WO2002072132A1 (en) | 2001-03-09 | 2002-03-07 | Combinations of heparin cofactor ii agonist and platelet iib/iiia antagonist, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525917A JP2004525917A (ja) | 2004-08-26 |
| JP2004525917A5 true JP2004525917A5 (https=) | 2006-01-05 |
Family
ID=25184646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571091A Pending JP2004525917A (ja) | 2001-03-09 | 2002-03-07 | ヘパリンコファクターｉｉアゴニストと血小板ｉｉｂ／ｉｉｉａ受容体アンタゴニストとの組み合わせ、およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6518244B2 (https=) |
| EP (1) | EP1377309A1 (https=) |
| JP (1) | JP2004525917A (https=) |
| CA (1) | CA2440557C (https=) |
| WO (1) | WO2002072132A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10135315A1 (de) * | 2001-07-19 | 2003-01-30 | Bayer Ag | Stents |
| US6908907B2 (en) * | 2002-04-22 | 2005-06-21 | El-Naggar Mawaheb M. | Prevention and treatment of tumor growth, metastasis, and thromboembolic complications in cancer patients |
| US7132398B2 (en) * | 2003-05-06 | 2006-11-07 | Dendreon Corporation | Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor |
| WO2005087266A1 (en) * | 2004-03-05 | 2005-09-22 | Vddi Pharmaceuticals | Combination therapy for inhibition of platelet aggregation |
| AU2005229015C1 (en) | 2004-04-02 | 2013-01-17 | The Regents Of The University Of California | Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin |
| US20050261241A1 (en) * | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
| NL2000126C2 (nl) * | 2005-07-15 | 2008-01-29 | Solvay | Werkwijze voor de vervaardiging van eptifibatide. |
| US8986713B2 (en) * | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
| US20080279909A1 (en) * | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
| US8496953B2 (en) * | 2006-05-12 | 2013-07-30 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having a high degree of biological activity following sterilization |
| US9114194B2 (en) * | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
| US8021677B2 (en) | 2006-05-12 | 2011-09-20 | Gore Enterprise Holdings, Inc. | Immobilized biologically active entities having a high degree of biological activity |
| US8591932B2 (en) * | 2009-09-17 | 2013-11-26 | W. L. Gore & Associates, Inc. | Heparin entities and methods of use |
| ES2955183T3 (es) | 2011-03-11 | 2023-11-29 | Gore & Ass | Mejoras para las entidades biológicas inmovilizadas |
| MY200434A (en) * | 2016-02-17 | 2023-12-26 | Ent Tech Pty Ltd | Compositions and methods for the treatment of sinus disease and disorders |
| EP3731870B1 (en) | 2017-12-26 | 2025-11-12 | Liqmeds Limited | Liquid oral formulations for pde v inhibitors |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3124384C2 (de) | 1981-06-22 | 1985-05-15 | Herbert Prof. Dr. 1000 Berlin Voß | Dermatanpolysulfat, Verfahren zu dessen Herstellung und dieses enthaltendes virushemmendes Mittel |
| FR2584728B1 (fr) | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| US5770198A (en) | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
| US5686566A (en) | 1989-06-16 | 1997-11-11 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| CA2000650A1 (en) | 1989-10-13 | 1991-04-13 | Louis Jaques | Product and process for the treatment and prevention of intravascular thrombi and atherosclerosis |
| US6008193A (en) | 1990-03-02 | 1999-12-28 | Bio-Technology General Corp. | Methods of using human von Willebrand factor GPIb binding domain polypeptides |
| DK0527798T3 (da) | 1990-04-06 | 1997-12-15 | Jolla Cancer Res Found | Fremgangsmåde og sammensætning til behandling af thrombose |
| IL99537A (en) | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| EP0557406A4 (en) | 1990-11-01 | 1993-10-06 | Smith-Kline Beecham Corporation | -g(g)-turn peptidomimetics as fibrinogen antagonists |
| WO1992019595A1 (en) | 1991-05-07 | 1992-11-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| IT1251182B (it) | 1991-08-28 | 1995-05-04 | Opocrin Spa | Oligosaccaridi di dermatan solfato, processo per la loro produzione e relative composizioni farmaceutiche. |
| IT1251183B (it) | 1991-08-28 | 1995-05-04 | Opocrin Spa | Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono. |
| US5635477A (en) * | 1991-09-30 | 1997-06-03 | The Dupont Merck Pharmaceutical Company | Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA |
| JP2855307B2 (ja) | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
| US5227490A (en) | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5312923A (en) | 1992-02-28 | 1994-05-17 | Merck & Co., Inc. | Process for preparing fibrinogen receptor antagonists |
| WO1994009034A1 (en) | 1992-10-12 | 1994-04-28 | Agen Limited | Clot directed anticoagulant, process for making same and methods of use |
| US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| US5731324A (en) | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| US5972967A (en) | 1996-10-23 | 1999-10-26 | Merck & Co., Inc. | Compositions for inhibiting platelet aggregation |
| KR100240544B1 (ko) | 1995-12-20 | 2000-01-15 | 고바야시 유끼오 | 혈관 내막 비후 억제제 |
| US5952306A (en) | 1996-01-16 | 1999-09-14 | Merck & Co., Inc. | Integrin receptor antagonists |
| WO1997035592A1 (en) | 1996-03-28 | 1997-10-02 | G.D. Searle & Co. | Iib/iiia antagonists co-administered with aspirin and/or heparin |
| US5922690A (en) * | 1996-04-25 | 1999-07-13 | Van Gorp; Cornelius L. | Dermatan disulfate, an inhibitor of thrombin generation and activation |
| JP2002501936A (ja) | 1998-02-02 | 2002-01-22 | メルク エンド カムパニー インコーポレーテッド | 低分子量ヘパリンをＧＰＩＩｂ／ＩＩＩａ拮抗物質と組合わせて使用する血小板凝集の抑制 |
-
2001
- 2001-03-09 US US09/802,775 patent/US6518244B2/en not_active Expired - Lifetime
-
2002
- 2002-03-07 WO PCT/US2002/006969 patent/WO2002072132A1/en not_active Ceased
- 2002-03-07 CA CA2440557A patent/CA2440557C/en not_active Expired - Lifetime
- 2002-03-07 EP EP02717576A patent/EP1377309A1/en not_active Withdrawn
- 2002-03-07 JP JP2002571091A patent/JP2004525917A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004525917A5 (https=) | ||
| CA2440557A1 (en) | Combinations of heparin cofactor ii agonist and platelet iib/iiia antagonist, and uses thereof | |
| EP1971355A4 (en) | METHOD AND COMPOSITIONS FOR THE DISPOSAL OF ACTIVE SUBSTANCES WITH IMPROVED PHARMACOLOGICAL PROPERTIES | |
| AR078417A1 (es) | Composiciones de pelicula sublingual y bucal | |
| JP2011515499A5 (https=) | ||
| Laux et al. | Direct inhibitors of coagulation proteins–the end of the heparin and low-molecular-weight heparin era for anticoagulant therapy? | |
| EP2355851A4 (en) | NEW LIPIDS AND COMPOSITIONS FOR THE ADDITION OF THERAPEUTICS | |
| MA27366A1 (fr) | Nouveaux derives de thiophenylglycoside, methodes pour leur production, medicaments contenant lesdits composes et leur utilisation | |
| EP2099434A4 (en) | DEVICES, SYSTEMS AND METHOD FOR DISPOSING MEDICAMENTS | |
| EP1781257A4 (en) | PHARMACEUTICAL FORMULATIONS WITH MICROPARTICLES OR NANOPARTICLES OF AN AGENT | |
| EP1933785A4 (en) | COMPOSITIONS, SYSTEMS, KITS AND METHODS FOR THE ADMINISTRATION OF RAPAMYCIN ANALOGUE WITH PACLITAXEL USING MEDICAL DEVICES | |
| EP1756039A4 (en) | COMPOUNDS AND COMPOSITIONS FOR THE DISPOSAL OF ACTIVE SUBSTANCES | |
| EP1513825A4 (en) | ANTITU-CULINARY MEDICAMENT: COMPOSITIONS AND METHODS | |
| ATE401800T1 (de) | Hochintensive süssstoffzusammensetzung und deren abgabe | |
| EP1807146A4 (en) | COMPOSITION TO IMPROVE THE EFFICIENCY OF THE MEDICINAL PRODUCT | |
| FR2912746B1 (fr) | Nouveaux composes derives d'indole et compositions pharmaceutiques les contenant | |
| EP1919288A4 (en) | FAMOTIDINE- AND IBUPROGEN-BASED MEDICAMENTS AND THEIR ADMINISTRATION | |
| FR2873691B1 (fr) | Derives d'amino-piperidine, leur preparation et leur application en therapeutique | |
| FR2934995B1 (fr) | Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique | |
| FR2928149B1 (fr) | Composes derives d'azetidines, leur preparation et leur application en therapeutique | |
| KR20190072579A (ko) | 폴리믹신-알기네이트 올리고머 콘주게이트 | |
| ITVA20040031A1 (it) | Derivati di idrossialchil guar ad elevata velocita' di dissoluzione | |
| JP2005527498A5 (https=) | ||
| EP2129218A4 (en) | COMPOUNDS WITH A CYCLIC PART AND COMPOSITIONS FOR ACTIVE COMPOSITION | |
| FR2886851B1 (fr) | Composition a base d'une avermectine et de metronidazole notamment pour le traitement de la rosacee |