JP2011515499A5 - - Google Patents

Info

Publication number

JP2011515499A5

JP2011515499A5 JP2011502107A JP2011502107A JP2011515499A5 JP 2011515499 A5 JP2011515499 A5 JP 2011515499A5 JP 2011502107 A JP2011502107 A JP 2011502107A JP 2011502107 A JP2011502107 A JP 2011502107A JP 2011515499 A5 JP2011515499 A5 JP 2011515499A5

Authority

JP

Japan

Prior art keywords

compound according

glycan

collagen

sequence

amino acid

Prior art date

2009-03-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 11
• 150000001413 amino acids Chemical class 0.000 claims 8
• 150000004676 glycans Chemical class 0.000 claims 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 102000008186 Collagen Human genes 0.000 claims 5
• 108010035532 Collagen Proteins 0.000 claims 5
• 229920001436 collagen Polymers 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• 229920000045 Dermatan sulfate Polymers 0.000 claims 3
• 230000000699 topical effect Effects 0.000 claims 3
• 229920002307 Dextran Polymers 0.000 claims 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
• 101000777658 Homo sapiens Platelet glycoprotein 4 Proteins 0.000 claims 2
• 102100031574 Platelet glycoprotein 4 Human genes 0.000 claims 2
• AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 2
• 229940051593 dermatan sulfate Drugs 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 229960002897 heparin Drugs 0.000 claims 2
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 2
• 238000007911 parenteral administration Methods 0.000 claims 2
• OEANUJAFZLQYOD-CXAZCLJRSA-N (2r,3s,4r,5r,6r)-6-[(2r,3r,4r,5r,6r)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](OC)O[C@H](CO)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O1 OEANUJAFZLQYOD-CXAZCLJRSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 229920000936 Agarose Polymers 0.000 claims 1
• 229920002567 Chondroitin Polymers 0.000 claims 1
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
• 229920002971 Heparan sulfate Polymers 0.000 claims 1
• 102000011782 Keratins Human genes 0.000 claims 1
• 108010076876 Keratins Proteins 0.000 claims 1
• MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims 1
• 108010013639 Peptidoglycan Proteins 0.000 claims 1
• 102000001732 Small Leucine-Rich Proteoglycans Human genes 0.000 claims 1
• 108010040068 Small Leucine-Rich Proteoglycans Proteins 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims 1
• 239000006071 cream Substances 0.000 claims 1
• 229960002086 dextran Drugs 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000000499 gel Substances 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 1
• 229940099552 hyaluronan Drugs 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000001361 intraarterial administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 239000002674 ointment Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000010118 platelet activation Effects 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1