CA2440557C - Combinations of heparin cofactor ii agonist and platelet iib/iiia antagonist, and uses thereof - Google Patents
Combinations of heparin cofactor ii agonist and platelet iib/iiia antagonist, and uses thereof Download PDFInfo
- Publication number
- CA2440557C CA2440557C CA2440557A CA2440557A CA2440557C CA 2440557 C CA2440557 C CA 2440557C CA 2440557 A CA2440557 A CA 2440557A CA 2440557 A CA2440557 A CA 2440557A CA 2440557 C CA2440557 C CA 2440557C
- Authority
- CA
- Canada
- Prior art keywords
- agonist
- platelet
- receptor antagonist
- iiia receptor
- heparin cofactor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US09/802,775 US6518244B2 (en) | 2000-03-09 | 2001-03-09 | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
| US09/802,775 | 2001-03-09 | ||
| PCT/US2002/006969 WO2002072132A1 (en) | 2001-03-09 | 2002-03-07 | Combinations of heparin cofactor ii agonist and platelet iib/iiia antagonist, and uses thereof |
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| CA2440557A1 CA2440557A1 (en) | 2002-09-19 |
| CA2440557C true CA2440557C (en) | 2011-04-19 |
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| WO (1) | WO2002072132A1 (https=) |
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| WO2005087266A1 (en) * | 2004-03-05 | 2005-09-22 | Vddi Pharmaceuticals | Combination therapy for inhibition of platelet aggregation |
| AU2005229015C1 (en) | 2004-04-02 | 2013-01-17 | The Regents Of The University Of California | Methods and compositions for treating and preventing disease associated with alphaVbeta5 integrin |
| US20050261241A1 (en) * | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
| NL2000126C2 (nl) * | 2005-07-15 | 2008-01-29 | Solvay | Werkwijze voor de vervaardiging van eptifibatide. |
| US8986713B2 (en) * | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
| US20080279909A1 (en) * | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
| US8496953B2 (en) * | 2006-05-12 | 2013-07-30 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having a high degree of biological activity following sterilization |
| US9114194B2 (en) * | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
| US8021677B2 (en) | 2006-05-12 | 2011-09-20 | Gore Enterprise Holdings, Inc. | Immobilized biologically active entities having a high degree of biological activity |
| US8591932B2 (en) * | 2009-09-17 | 2013-11-26 | W. L. Gore & Associates, Inc. | Heparin entities and methods of use |
| ES2955183T3 (es) | 2011-03-11 | 2023-11-29 | Gore & Ass | Mejoras para las entidades biológicas inmovilizadas |
| MY200434A (en) * | 2016-02-17 | 2023-12-26 | Ent Tech Pty Ltd | Compositions and methods for the treatment of sinus disease and disorders |
| EP3731870B1 (en) | 2017-12-26 | 2025-11-12 | Liqmeds Limited | Liquid oral formulations for pde v inhibitors |
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| DE3124384C2 (de) | 1981-06-22 | 1985-05-15 | Herbert Prof. Dr. 1000 Berlin Voß | Dermatanpolysulfat, Verfahren zu dessen Herstellung und dieses enthaltendes virushemmendes Mittel |
| FR2584728B1 (fr) | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| US5770198A (en) | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
| US5686566A (en) | 1989-06-16 | 1997-11-11 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
| CA2000650A1 (en) | 1989-10-13 | 1991-04-13 | Louis Jaques | Product and process for the treatment and prevention of intravascular thrombi and atherosclerosis |
| US6008193A (en) | 1990-03-02 | 1999-12-28 | Bio-Technology General Corp. | Methods of using human von Willebrand factor GPIb binding domain polypeptides |
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| IL99537A (en) | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| EP0557406A4 (en) | 1990-11-01 | 1993-10-06 | Smith-Kline Beecham Corporation | -g(g)-turn peptidomimetics as fibrinogen antagonists |
| WO1992019595A1 (en) | 1991-05-07 | 1992-11-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| IT1251182B (it) | 1991-08-28 | 1995-05-04 | Opocrin Spa | Oligosaccaridi di dermatan solfato, processo per la loro produzione e relative composizioni farmaceutiche. |
| IT1251183B (it) | 1991-08-28 | 1995-05-04 | Opocrin Spa | Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono. |
| US5635477A (en) * | 1991-09-30 | 1997-06-03 | The Dupont Merck Pharmaceutical Company | Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA |
| JP2855307B2 (ja) | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
| US5227490A (en) | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5312923A (en) | 1992-02-28 | 1994-05-17 | Merck & Co., Inc. | Process for preparing fibrinogen receptor antagonists |
| WO1994009034A1 (en) | 1992-10-12 | 1994-04-28 | Agen Limited | Clot directed anticoagulant, process for making same and methods of use |
| US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| US5731324A (en) | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| US5972967A (en) | 1996-10-23 | 1999-10-26 | Merck & Co., Inc. | Compositions for inhibiting platelet aggregation |
| KR100240544B1 (ko) | 1995-12-20 | 2000-01-15 | 고바야시 유끼오 | 혈관 내막 비후 억제제 |
| US5952306A (en) | 1996-01-16 | 1999-09-14 | Merck & Co., Inc. | Integrin receptor antagonists |
| WO1997035592A1 (en) | 1996-03-28 | 1997-10-02 | G.D. Searle & Co. | Iib/iiia antagonists co-administered with aspirin and/or heparin |
| US5922690A (en) * | 1996-04-25 | 1999-07-13 | Van Gorp; Cornelius L. | Dermatan disulfate, an inhibitor of thrombin generation and activation |
| JP2002501936A (ja) | 1998-02-02 | 2002-01-22 | メルク エンド カムパニー インコーポレーテッド | 低分子量ヘパリンをＧＰＩＩｂ／ＩＩＩａ拮抗物質と組合わせて使用する血小板凝集の抑制 |
-
2001
- 2001-03-09 US US09/802,775 patent/US6518244B2/en not_active Expired - Lifetime
-
2002
- 2002-03-07 WO PCT/US2002/006969 patent/WO2002072132A1/en not_active Ceased
- 2002-03-07 CA CA2440557A patent/CA2440557C/en not_active Expired - Lifetime
- 2002-03-07 EP EP02717576A patent/EP1377309A1/en not_active Withdrawn
- 2002-03-07 JP JP2002571091A patent/JP2004525917A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1377309A1 (en) | 2004-01-07 |
| CA2440557A1 (en) | 2002-09-19 |
| US20010036932A1 (en) | 2001-11-01 |
| JP2004525917A (ja) | 2004-08-26 |
| WO2002072132A1 (en) | 2002-09-19 |
| US6518244B2 (en) | 2003-02-11 |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20220307 |