JP2004525906A5 - - Google Patents
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- Publication number
- JP2004525906A5 JP2004525906A5 JP2002567895A JP2002567895A JP2004525906A5 JP 2004525906 A5 JP2004525906 A5 JP 2004525906A5 JP 2002567895 A JP2002567895 A JP 2002567895A JP 2002567895 A JP2002567895 A JP 2002567895A JP 2004525906 A5 JP2004525906 A5 JP 2004525906A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- compound according
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 32
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 239000001257 hydrogen Substances 0.000 claims 19
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 150000001721 carbon Chemical group 0.000 claims 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000004898 mitochondrial function Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27236801P | 2001-02-27 | 2001-02-27 | |
| PCT/US2002/006717 WO2002068381A2 (en) | 2001-02-27 | 2002-02-27 | Aryl-n-cyanoguanidines and methods related thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525906A JP2004525906A (ja) | 2004-08-26 |
| JP2004525906A5 true JP2004525906A5 (https=) | 2005-12-22 |
Family
ID=23039505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567895A Pending JP2004525906A (ja) | 2001-02-27 | 2002-02-27 | アリールｎ−シアノグアニジンおよびこれに関連する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6562821B2 (https=) |
| EP (1) | EP1377282B1 (https=) |
| JP (1) | JP2004525906A (https=) |
| AT (1) | ATE336237T1 (https=) |
| AU (1) | AU2002254124A1 (https=) |
| CA (1) | CA2475454A1 (https=) |
| DE (1) | DE60213958T2 (https=) |
| ES (1) | ES2271247T3 (https=) |
| WO (1) | WO2002068381A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60213958T2 (de) * | 2001-02-27 | 2007-08-30 | Migenix Corp., San Diego | Aryl-n-cyanoguanidine derivate und deren verwendung |
| US7411000B2 (en) * | 2001-03-15 | 2008-08-12 | The Scripps Research Institute | Process of inhibiting cell death in injured cartilage |
| US6916813B2 (en) * | 2001-12-10 | 2005-07-12 | Bristol-Myers Squibb Co. | (1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase |
| US7642092B2 (en) * | 2003-03-03 | 2010-01-05 | Technion Research & Development Foundation Ltd. | Cultured cartilage/bone cells/tissue, method of generating same and uses thereof |
| EP3747449A4 (en) * | 2018-02-02 | 2021-10-20 | Paean Biotechnology Inc. | PHARMACEUTICAL COMPOSITION WITH ISOLATED MITOCHONDRIA FOR THE PREVENTION OR TREATMENT OF RHEUMATOID ARTHRITIS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4265905A (en) | 1975-09-30 | 1981-05-05 | Merck & Co., Inc. | Method of treating inflammation employing acyl cyanoguanidines |
| GB8400863D0 (en) * | 1984-01-13 | 1984-02-15 | Smith Kline French Lab | Chemical compounds |
| CN1450999A (zh) * | 2000-03-31 | 2003-10-22 | 辉瑞产品公司 | 新的哌嗪衍生物 |
| DE60213958T2 (de) * | 2001-02-27 | 2007-08-30 | Migenix Corp., San Diego | Aryl-n-cyanoguanidine derivate und deren verwendung |
-
2002
- 2002-02-27 DE DE60213958T patent/DE60213958T2/de not_active Expired - Fee Related
- 2002-02-27 AT AT02723339T patent/ATE336237T1/de not_active IP Right Cessation
- 2002-02-27 EP EP02723339A patent/EP1377282B1/en not_active Expired - Lifetime
- 2002-02-27 ES ES02723339T patent/ES2271247T3/es not_active Expired - Lifetime
- 2002-02-27 CA CA002475454A patent/CA2475454A1/en not_active Abandoned
- 2002-02-27 AU AU2002254124A patent/AU2002254124A1/en not_active Abandoned
- 2002-02-27 JP JP2002567895A patent/JP2004525906A/ja active Pending
- 2002-02-27 WO PCT/US2002/006717 patent/WO2002068381A2/en not_active Ceased
- 2002-02-27 US US10/085,119 patent/US6562821B2/en not_active Expired - Fee Related
-
2003
- 2003-03-11 US US10/386,154 patent/US6927218B2/en not_active Expired - Fee Related
-
2005
- 2005-01-21 US US11/040,196 patent/US7230132B2/en not_active Expired - Fee Related
-
2007
- 2007-05-04 US US11/744,532 patent/US20080032981A1/en not_active Abandoned
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