JP2004525618A - スプライセオソームにより媒介されるｒｎａトランススプライシング - Google Patents
スプライセオソームにより媒介されるｒｎａトランススプライシング Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
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- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
- C12N2840/445—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor for trans-splicing, e.g. polypyrimidine tract, branch point splicing
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/756,096 US20030077754A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US09/756,097 US20060088938A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants |
| US09/756,095 US20020115207A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US09/838,858 US20030148937A1 (en) | 1995-12-15 | 2001-04-20 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US09/941,492 US20030027250A1 (en) | 1995-12-15 | 2001-08-29 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| PCT/US2002/000416 WO2002053581A2 (en) | 2001-01-08 | 2002-01-08 | Spliceosome mediated rna trans-splicing |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005003107A Division JP2005168509A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるｒｎａトランススプライシング |
| JP2005003076A Division JP2005176849A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるｒｎａトランススプライシング |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525618A true JP2004525618A (ja) | 2004-08-26 |
| JP2004525618A5 JP2004525618A5 (https=) | 2006-01-05 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002555104A Pending JP2004525618A (ja) | 2001-01-08 | 2002-01-08 | スプライセオソームにより媒介されるｒｎａトランススプライシング |
| JP2005003076A Pending JP2005176849A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるｒｎａトランススプライシング |
| JP2005003107A Pending JP2005168509A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるｒｎａトランススプライシング |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005003076A Pending JP2005176849A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるｒｎａトランススプライシング |
| JP2005003107A Pending JP2005168509A (ja) | 2001-01-08 | 2005-01-07 | スプライセオソームにより媒介されるｒｎａトランススプライシング |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1358203A4 (https=) |
| JP (3) | JP2004525618A (https=) |
| AU (1) | AU2002246959B2 (https=) |
| CA (1) | CA2434118A1 (https=) |
| IL (3) | IL156665A0 (https=) |
| WO (1) | WO2002053581A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008515441A (ja) * | 2004-10-08 | 2008-05-15 | バークシス コーポレーション | 組換えタンパク質をインビボ生産するための、非常に豊富な転写産物の標的化トランススプライシング |
| JP2008515435A (ja) * | 2004-10-08 | 2008-05-15 | バークシス コーポレーション | 抗体遺伝子導入および抗体ポリペプチド産生のためのｒｎａトランススプライシングの使用 |
| JP2008187936A (ja) * | 2007-02-02 | 2008-08-21 | Fujifilm Corp | トランススプライシング法による融合タンパク質作製方法 |
| JP2017520255A (ja) * | 2014-07-03 | 2017-07-27 | ジェネンテック， インコーポレイテッド | ポリペプチド発現系 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10139492B4 (de) * | 2001-08-13 | 2004-06-09 | Eul, Joachim, Dr. | Verfahren zur Reparatur einer mutierten RNA aus einer gendefekten DNA und zum gezielten Abtöten von Tumorzellen durch RNA-Transspleißen sowie Verfahren zum Nachweis von natürlich-transgespleißter zellulärer RNA |
| EP1521766B1 (en) * | 2002-06-05 | 2012-11-07 | VIRxSYS Corporation | SPLICEOSOME MEDIATED RNA i TRANS /i -SPLICING AND CORRECTION OF FACTOR VIII GENETIC DEFECTS USING SPLICEOSOME MEDIATED RNA TRANS SPLING |
| EP1716165A4 (en) * | 2004-01-23 | 2008-06-18 | Virxsys Corp | EXPRESSION OF APOA-1 AND VARIANTS THEREOF, USING SPSSISSOSOM-MEDIATED RNA TRANS MIXING |
| SG2014012207A (en) * | 2011-08-12 | 2014-05-29 | Virxsys Corp | Compositions and methods for inducing apoptosis |
| EP4217010A4 (en) * | 2020-09-28 | 2025-01-08 | Tacit Therapeutics, Inc. | TRANS-SPLICING SYSTEM FOR TISSUE-SPECIFIC REPLACEMENT OF RNA SEQUENCES |
| WO2022220968A1 (en) * | 2021-04-15 | 2022-10-20 | U1 Bio, Inc. | High efficiency trans-splicing for replacement of targeted rna sequences in human cells |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6280978B1 (en) * | 1995-12-15 | 2001-08-28 | Intronn Holdings, Llc | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| ATE354957T1 (de) * | 1995-12-15 | 2006-03-15 | Intronn Inc | Durch trans-spaltung erhaltene therapeutische molekule |
-
2002
- 2002-01-08 JP JP2002555104A patent/JP2004525618A/ja active Pending
- 2002-01-08 AU AU2002246959A patent/AU2002246959B2/en not_active Ceased
- 2002-01-08 IL IL15666502A patent/IL156665A0/xx unknown
- 2002-01-08 EP EP02714709A patent/EP1358203A4/en not_active Withdrawn
- 2002-01-08 IL IL16505602A patent/IL165056A0/xx unknown
- 2002-01-08 WO PCT/US2002/000416 patent/WO2002053581A2/en not_active Ceased
- 2002-01-08 CA CA002434118A patent/CA2434118A1/en not_active Abandoned
-
2004
- 2004-11-04 IL IL16505704A patent/IL165057A0/xx unknown
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2005
- 2005-01-07 JP JP2005003076A patent/JP2005176849A/ja active Pending
- 2005-01-07 JP JP2005003107A patent/JP2005168509A/ja active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008515441A (ja) * | 2004-10-08 | 2008-05-15 | バークシス コーポレーション | 組換えタンパク質をインビボ生産するための、非常に豊富な転写産物の標的化トランススプライシング |
| JP2008515435A (ja) * | 2004-10-08 | 2008-05-15 | バークシス コーポレーション | 抗体遺伝子導入および抗体ポリペプチド産生のためのｒｎａトランススプライシングの使用 |
| JP2008187936A (ja) * | 2007-02-02 | 2008-08-21 | Fujifilm Corp | トランススプライシング法による融合タンパク質作製方法 |
| JP2017520255A (ja) * | 2014-07-03 | 2017-07-27 | ジェネンテック， インコーポレイテッド | ポリペプチド発現系 |
| US11851661B2 (en) | 2014-07-03 | 2023-12-26 | Genentech, Inc. | Polypeptide expression systems |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005168509A (ja) | 2005-06-30 |
| IL156665A0 (en) | 2004-01-04 |
| JP2005176849A (ja) | 2005-07-07 |
| EP1358203A4 (en) | 2006-11-22 |
| IL165057A0 (en) | 2005-12-18 |
| AU2002246959B2 (en) | 2008-03-06 |
| IL165056A0 (en) | 2005-12-18 |
| EP1358203A2 (en) | 2003-11-05 |
| WO2002053581A3 (en) | 2002-09-26 |
| WO2002053581A2 (en) | 2002-07-11 |
| CA2434118A1 (en) | 2002-07-11 |
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