JP2004523579A5 - - Google Patents
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- Publication number
- JP2004523579A5 JP2004523579A5 JP2002573044A JP2002573044A JP2004523579A5 JP 2004523579 A5 JP2004523579 A5 JP 2004523579A5 JP 2002573044 A JP2002573044 A JP 2002573044A JP 2002573044 A JP2002573044 A JP 2002573044A JP 2004523579 A5 JP2004523579 A5 JP 2004523579A5
- Authority
- JP
- Japan
- Prior art keywords
- hmg box
- molecule
- preparation
- therapeutic agent
- hmg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 208000019553 vascular disease Diseases 0.000 claims 3
- 102100029599 Advanced glycosylation end product-specific receptor Human genes 0.000 claims 2
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims 2
- 102000055207 HMGB1 Human genes 0.000 claims 2
- 108700010013 HMGB1 Proteins 0.000 claims 2
- 101150021904 HMGB1 gene Proteins 0.000 claims 2
- 101001061840 Homo sapiens Advanced glycosylation end product-specific receptor Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 210000002808 connective tissue Anatomy 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000004210 Pressure Ulcer Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 230000007838 tissue remodeling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI000562A ITMI20010562A1 (it) | 2001-03-16 | 2001-03-16 | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| ITMI2001A000562 | 2001-03-16 | ||
| PCT/IT2002/000153 WO2002074337A1 (en) | 2001-03-16 | 2002-03-12 | Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004523579A JP2004523579A (ja) | 2004-08-05 |
| JP2004523579A5 true JP2004523579A5 (cg-RX-API-DMAC7.html) | 2005-08-18 |
| JP4822654B2 JP4822654B2 (ja) | 2011-11-24 |
Family
ID=11447291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573044A Expired - Fee Related JP4822654B2 (ja) | 2001-03-16 | 2002-03-12 | 血管疾患治療用ｈｍｇｂ１蛋白質インヒビタおよび／またはアンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7754217B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1368060B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4822654B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101773669A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE468137T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002247977C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2439530C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60236413D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1368060T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2346408T3 (cg-RX-API-DMAC7.html) |
| IT (1) | ITMI20010562A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA03008364A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1368060E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002074337A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7151082B2 (en) | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| IL158643A0 (en) * | 2001-05-15 | 2004-05-12 | Long Island Jewish Res Inst | Use of hmg fragments as anti-inflammatory agents |
| US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| CA2491321A1 (en) | 2002-07-03 | 2004-01-15 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair |
| EP1579221A2 (de) * | 2003-01-03 | 2005-09-28 | Alcedo Biotech GmbH | Verwendungen von hmgb, hmgn, hmga proteinen |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| ITRM20040058A1 (it) * | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
| WO2006002971A2 (en) * | 2004-07-02 | 2006-01-12 | Creabilis Therapeutics S.P.A. | Nucleic acids for the treatment of hmgb1-related pathologies |
| JP2008507505A (ja) | 2004-07-20 | 2008-03-13 | プロヴィンシア・イタリアーナ・デッラ・コングレガチォーネ・フィリ・デッリマコラータ・コンセチォーネ−イスティトゥト・デルモパティコ・デッリマコラータ−アイ・アール・シー・シー・エス | 創傷治癒のためのｈｍｇｂ１の使用 |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| WO2006024547A2 (en) * | 2004-09-03 | 2006-03-09 | Creabilis Therapeutics S.P.A. | Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use |
| CA2585043A1 (en) | 2004-10-22 | 2007-01-04 | Medimmune, Inc. | High affinity antibodies against hmgb1 and methods of use thereof |
| US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
| ITRM20050032A1 (it) * | 2005-01-21 | 2006-07-22 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di inibire la patogenesi e la progressione della malattia aterosclerotica. |
| WO2006114805A2 (en) * | 2005-04-28 | 2006-11-02 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb2 and hmgb3 proteins for medical applications |
| EP1909834A2 (en) | 2005-07-18 | 2008-04-16 | Critical Therapeutics, Inc. | Use of hmgb1 antagonists for the treatment of inflammatory skin conditions |
| BRPI0615277A2 (pt) | 2005-08-25 | 2009-08-04 | Creabilis Therapeutics Spa | conjugado de polìmeros de k-252a, composição farmacêutica compreendendo o referido conjugado, bem como uso do mesmo |
| WO2007031100A1 (en) * | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
| JP2009517404A (ja) | 2005-11-28 | 2009-04-30 | メディミューン，エルエルシー | Ｈｍｇｂ１および／またはｒａｇｅのアンタゴニストならびにその使用方法 |
| US7829097B2 (en) * | 2006-02-06 | 2010-11-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of HMGB1 for protection against ischemia reperfusion injury |
| HRP20110487T1 (hr) | 2006-09-15 | 2011-08-31 | Creabilis Therapeutics S.R.L. | Polimerni konjugati hmgb1 box-a i varijanti hmgb1 box-a |
| US8470325B2 (en) | 2007-02-15 | 2013-06-25 | Kagoshima University | Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody |
| JP5676253B2 (ja) | 2008-04-30 | 2015-02-25 | 株式会社ジェノミックス | 生体内機能的細胞の高効率採取法 |
| EP2301559A4 (en) | 2008-04-30 | 2012-05-02 | Genomix Co Ltd | MEDIUM FOR THE RECRUITMENT OF PLURIPOTENTIAL STEM CELLS FROM BONE MARROW IN THE PERIPHERAL CYCLE |
| US9278108B2 (en) | 2009-07-16 | 2016-03-08 | Nec Solution Innovators, Ltd. | HMGB1 binding nucleic acid molecule and applications thereof |
| JP5467313B2 (ja) | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| RU2599448C2 (ru) | 2009-10-28 | 2016-10-10 | Дженомикс Ко., Лтд. | Средства для стимуляции регенерации тканей путем привлечения мезенхимных стволовых клеток и/или плюрипотентных стволовых клеток костного мозга в кровь |
| US9138458B2 (en) | 2010-10-30 | 2015-09-22 | Isis Innovation Limited | Treatment for dupuytren's disease |
| CN107188948B (zh) | 2011-04-26 | 2021-11-30 | 斯特姆里姆有限公司 | 用于诱导组织再生的肽及其应用 |
| WO2012170742A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Treatment and prevention of cancer with hmgb1 antagonists |
| US9244074B2 (en) * | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| CN104955470B (zh) | 2012-10-25 | 2017-06-16 | 吉诺米克斯股份有限公司 | 利用了hmgb1片段的针对脊髄损伤的新型治疗方法 |
| DK2913058T3 (en) | 2012-10-25 | 2018-02-19 | Genomix Co Ltd | Hitherto unknown method of treatment of myocardial infarction using HMGB1 fragment |
| ES2865735T3 (es) | 2013-01-28 | 2021-10-15 | Evec Inc | Anticuerpo anti-hmgb1 humanizado o fragmento de unión a antígeno del mismo |
| IL242807A0 (en) | 2015-11-26 | 2016-04-21 | Novamed Ltd | Test facility |
| EP3386529A2 (en) | 2015-12-11 | 2018-10-17 | Ruprecht-Karls-Universität Heidelberg | Combined preparations of pkm2 modulators and hmgb1 |
| TWI805565B (zh) | 2017-01-27 | 2023-06-21 | 日商斯德武利姆股份有限公司 | 心肌病、陳舊性心肌梗塞及慢性心臟衰竭的治療藥物 |
| EP3718561A4 (en) | 2017-12-01 | 2021-07-21 | Stemrim Inc. | Therapy for inflammatory bowel disease |
| CA3084013A1 (en) | 2017-12-01 | 2019-06-06 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| EP3750553A4 (en) | 2018-02-08 | 2022-01-12 | Stemrim Inc. | THERAPEUTIC FOR PSORIASIS |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| CN115361966B (zh) * | 2020-04-22 | 2025-09-16 | 朱拉隆功大学 | 使dna恢复活力和防止dna损伤的组合物以及方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5470307A (en) * | 1994-03-16 | 1995-11-28 | Lindall; Arnold W. | Catheter system for controllably releasing a therapeutic agent at a remote tissue site |
| AU1832797A (en) | 1996-01-26 | 1997-08-20 | Trustees Of Columbia University In The City Of New York, The | A polypeptide from lung extract which binds amyloid-beta peptide |
| US5864018A (en) * | 1996-04-16 | 1999-01-26 | Schering Aktiengesellschaft | Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor |
| AU2696097A (en) | 1996-04-16 | 1997-11-07 | Schering Aktiengesellschaft | Advanced glycosylation end-product receptor peptides and uses therefor |
| US6790443B2 (en) | 1996-11-22 | 2004-09-14 | The Trustees Of Columbia University In The City Of New York | Method for treating symptoms of diabetes |
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US6398808B1 (en) | 1999-06-15 | 2002-06-04 | Scimed Life Systems, Inc. | Localized delivery of genetic information from biostable materials |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| IL158643A0 (en) * | 2001-05-15 | 2004-05-12 | Long Island Jewish Res Inst | Use of hmg fragments as anti-inflammatory agents |
| ITRM20040058A1 (it) * | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
| JP2008507505A (ja) * | 2004-07-20 | 2008-03-13 | プロヴィンシア・イタリアーナ・デッラ・コングレガチォーネ・フィリ・デッリマコラータ・コンセチォーネ−イスティトゥト・デルモパティコ・デッリマコラータ−アイ・アール・シー・シー・エス | 創傷治癒のためのｈｍｇｂ１の使用 |
| WO2008137552A2 (en) * | 2007-05-02 | 2008-11-13 | Medimmune, Llc | Anti-rage antibodies and methods of use thereof |
-
2001
- 2001-03-16 IT IT2001MI000562A patent/ITMI20010562A1/it unknown
- 2001-03-16 US US10/471,641 patent/US7754217B2/en not_active Expired - Fee Related
-
2002
- 2002-03-12 PT PT02717057T patent/PT1368060E/pt unknown
- 2002-03-12 AT AT02717057T patent/ATE468137T1/de active
- 2002-03-12 EP EP02717057A patent/EP1368060B1/en not_active Expired - Lifetime
- 2002-03-12 DE DE60236413T patent/DE60236413D1/de not_active Expired - Lifetime
- 2002-03-12 CA CA2439530A patent/CA2439530C/en not_active Expired - Fee Related
- 2002-03-12 WO PCT/IT2002/000153 patent/WO2002074337A1/en not_active Ceased
- 2002-03-12 DK DK02717057.0T patent/DK1368060T3/da active
- 2002-03-12 CN CN200910252323A patent/CN101773669A/zh active Pending
- 2002-03-12 MX MXPA03008364A patent/MXPA03008364A/es active IP Right Grant
- 2002-03-12 JP JP2002573044A patent/JP4822654B2/ja not_active Expired - Fee Related
- 2002-03-12 CN CN028065670A patent/CN1537014B/zh not_active Expired - Fee Related
- 2002-03-12 AU AU2002247977A patent/AU2002247977C1/en not_active Ceased
- 2002-03-12 ES ES02717057T patent/ES2346408T3/es not_active Expired - Lifetime
-
2008
- 2008-01-02 US US11/968,506 patent/US8058239B2/en not_active Expired - Fee Related
-
2010
- 2010-02-17 US US12/707,222 patent/US20100172896A1/en not_active Abandoned
- 2010-02-17 US US12/707,264 patent/US20100297107A1/en not_active Abandoned
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