JP2004523559A5 - - Google Patents

Info

Publication number

JP2004523559A5

JP2004523559A5 JP2002567309A JP2002567309A JP2004523559A5 JP 2004523559 A5 JP2004523559 A5 JP 2004523559A5 JP 2002567309 A JP2002567309 A JP 2002567309A JP 2002567309 A JP2002567309 A JP 2002567309A JP 2004523559 A5 JP2004523559 A5 JP 2004523559A5

Authority

JP

Japan

Prior art keywords

tetrahydro

dioxo

purin

bis

methyl ether

Prior art date

2002-02-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• -1 substituted C 6 aryl Chemical group 0.000 claims 172
• 125000000217 alkyl group Chemical group 0.000 claims 40
• RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 26
• 229940114081 cinnamate Drugs 0.000 claims 22
• 229920000847 nonoxynol Polymers 0.000 claims 18
• LERWZBXJAOSNBN-DTQAZKPQSA-N (e)-3-[4-[1,3-bis(cyclohexylmethyl)-2,6-dioxo-7h-purin-8-yl]phenyl]prop-2-enoic acid Chemical compound C1=CC(/C=C/C(=O)O)=CC=C1C1=NC(C(N(CC2CCCCC2)C(=O)N2CC3CCCCC3)=O)=C2N1 LERWZBXJAOSNBN-DTQAZKPQSA-N 0.000 claims 14
• 150000002148 esters Chemical class 0.000 claims 14
• 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 12
• 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 12
• 125000003118 aryl group Chemical group 0.000 claims 12
• 150000001408 amides Chemical class 0.000 claims 10
• 150000001875 compounds Chemical class 0.000 claims 10
• 229910052760 oxygen Inorganic materials 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
• 239000012453 solvate Substances 0.000 claims 10
• 229910052717 sulfur Inorganic materials 0.000 claims 10
• 239000003814 drug Substances 0.000 claims 9
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 8
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 8
• 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 8
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 8
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
• 241001465754 Metazoa Species 0.000 claims 8
• 125000003710 aryl alkyl group Chemical group 0.000 claims 8
• 229910052799 carbon Inorganic materials 0.000 claims 8
• 125000001072 heteroaryl group Chemical group 0.000 claims 8
• 125000000623 heterocyclic group Chemical group 0.000 claims 8
• 229910052739 hydrogen Inorganic materials 0.000 claims 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
• LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 6
• 230000002265 prevention Effects 0.000 claims 6
• PHPTYNIVTRERGL-CCEZHUSRSA-N (e)-3-[3-[1,3-bis(cyclohexylmethyl)-2,6-dioxo-7h-purin-8-yl]phenyl]prop-2-enoic acid Chemical compound OC(=O)\C=C\C1=CC=CC(C=2NC3=C(C(N(CC4CCCCC4)C(=O)N3CC3CCCCC3)=O)N=2)=C1 PHPTYNIVTRERGL-CCEZHUSRSA-N 0.000 claims 4
• CNGGDAGBSQGQJU-UHFFFAOYSA-N 8-[4-(aminomethyl)phenyl]-1,3-bis(cyclohexylmethyl)-7h-purine-2,6-dione Chemical compound C1=CC(CN)=CC=C1C1=NC(C(N(CC2CCCCC2)C(=O)N2CC3CCCCC3)=O)=C2N1 CNGGDAGBSQGQJU-UHFFFAOYSA-N 0.000 claims 4
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
• 102100038591 Endothelial cell-selective adhesion molecule Human genes 0.000 claims 4
• 101000882622 Homo sapiens Endothelial cell-selective adhesion molecule Proteins 0.000 claims 4
• CCRCUPLGCSFEDV-UHFFFAOYSA-N cinnamic acid methyl ester Natural products COC(=O)C=CC1=CC=CC=C1 CCRCUPLGCSFEDV-UHFFFAOYSA-N 0.000 claims 4
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 4
• 208000010643 digestive system disease Diseases 0.000 claims 4
• 125000000524 functional group Chemical group 0.000 claims 4
• 208000018685 gastrointestinal system disease Diseases 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 239000003112 inhibitor Substances 0.000 claims 4
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 125000004430 oxygen atom Chemical group O* 0.000 claims 4
• 125000003107 substituted aryl group Chemical group 0.000 claims 4
• IJVFPDHKTFXORE-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol propanoic acid Chemical class COCCOCCOCCOCCOCCOCCOCCOCCOCCO.C(CC)(=O)O IJVFPDHKTFXORE-UHFFFAOYSA-N 0.000 claims 2
• WGKYSFRFMQHMOF-UHFFFAOYSA-N 3-bromo-5-methylpyridine-2-carbonitrile Chemical compound CC1=CN=C(C#N)C(Br)=C1 WGKYSFRFMQHMOF-UHFFFAOYSA-N 0.000 claims 2
• BUUVGKATBLTPSK-UHFFFAOYSA-N 8-[4-(aminomethyl)phenyl]-1,3-bis(cyclohexylmethyl)-7h-purine-2,6-dione;2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound COCCOCCOCCOCCOCCOCCOCCO.C1=CC(CN)=CC=C1C(N1)=NC2=C1C(=O)N(CC1CCCCC1)C(=O)N2CC1CCCCC1 BUUVGKATBLTPSK-UHFFFAOYSA-N 0.000 claims 2
• XWSKURWERJWSKI-UHFFFAOYSA-N COCCOCCOCCOCCOCCOCCOCCOCCOCCO.C(C=CC1=CC=CC=C1)(=O)O Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCO.C(C=CC1=CC=CC=C1)(=O)O XWSKURWERJWSKI-UHFFFAOYSA-N 0.000 claims 2
• SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
• DNMZJIGSDQVGSA-UHFFFAOYSA-N methoxymethane;hydrochloride Chemical compound Cl.COC DNMZJIGSDQVGSA-UHFFFAOYSA-N 0.000 claims 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
• 239000000377 silicon dioxide Substances 0.000 claims 2