JP2004520812A5 - - Google Patents
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- Publication number
- JP2004520812A5 JP2004520812A5 JP2002522564A JP2002522564A JP2004520812A5 JP 2004520812 A5 JP2004520812 A5 JP 2004520812A5 JP 2002522564 A JP2002522564 A JP 2002522564A JP 2002522564 A JP2002522564 A JP 2002522564A JP 2004520812 A5 JP2004520812 A5 JP 2004520812A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotides
- nucleic acid
- bound
- spacers
- bead sets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 11
- 239000011324 bead Substances 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 8
- 108700028369 Alleles Proteins 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 125000006850 spacer group Chemical group 0.000 claims 6
- 238000009396 hybridization Methods 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22899400P | 2000-08-30 | 2000-08-30 | |
| PCT/US2001/041956 WO2002018659A2 (en) | 2000-08-30 | 2001-08-30 | Method for determining alleles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004520812A JP2004520812A (ja) | 2004-07-15 |
| JP2004520812A5 true JP2004520812A5 (https=) | 2005-03-17 |
Family
ID=22859388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522564A Withdrawn JP2004520812A (ja) | 2000-08-30 | 2001-08-30 | 対立遺伝子を決定するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2004520812A (https=) |
| CN (1) | CN1293204C (https=) |
| AU (1) | AU2001289177A1 (https=) |
| CA (1) | CA2421078A1 (https=) |
| WO (1) | WO2002018659A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005525787A (ja) * | 2001-10-24 | 2005-09-02 | シンギュレックス・インコーポレイテッド | プローブとの相互作用による遺伝子ハプロタイプの検出方法 |
| MX359371B (es) | 2001-11-13 | 2018-09-25 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| DK2573170T3 (en) | 2001-12-17 | 2018-04-09 | Univ Pennsylvania | Sequences of adeno-associated virus (AAV) serotype 9, vectors containing them, and their use |
| PT1453547T (pt) | 2001-12-17 | 2016-12-28 | Univ Pennsylvania | Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas |
| JP3752466B2 (ja) | 2002-04-24 | 2006-03-08 | 株式会社日立製作所 | 遺伝子検査方法 |
| EP1536021A1 (en) | 2003-11-27 | 2005-06-01 | Consortium National de Recherche en Genomique (CNRG) | Method for HLA typing |
| GB0406863D0 (en) * | 2004-03-26 | 2004-04-28 | Qiagen As | Nucleic acid sequencing |
| US20050282195A1 (en) * | 2004-04-30 | 2005-12-22 | Applera Corporation | Compositions, methods, and kits for (MIS)ligating oligonucleotides |
| GB0600116D0 (en) * | 2006-01-05 | 2006-02-15 | Univ Cardiff | Allele-specific sequencing |
| WO2009067280A1 (en) * | 2007-08-07 | 2009-05-28 | Monsanto Technology Llc | Methods and compositions for selecting soybean plants resistant to southern root knot nematode |
| EP2411543B1 (en) * | 2009-03-27 | 2017-04-19 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| JP2011072222A (ja) * | 2009-09-29 | 2011-04-14 | Kitasato Otsuka Biomedical Assay Kenkyusho:Kk | 標的核酸の検出方法 |
| AU2011224534B2 (en) | 2010-03-08 | 2014-10-09 | Dana-Farber Cancer Institute, Inc. | Full COLD-PCR enrichment with reference blocking sequence |
| JP2014507950A (ja) * | 2011-02-28 | 2014-04-03 | トランスゲノミック，インク． | 混合個体群における標的ｄｎａを配列決定するためのキットおよび方法 |
| EP2691541B1 (en) | 2011-03-31 | 2017-10-18 | Dana-Farber Cancer Institute, Inc. | Method for enriching in single-stranded mutant sequences from mixture of wild-type and mutant sequences |
| US9133490B2 (en) | 2012-05-16 | 2015-09-15 | Transgenomic, Inc. | Step-up method for COLD-PCR enrichment |
| US10913977B2 (en) | 2013-07-24 | 2021-02-09 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to enable enrichment of minor DNA alleles by limiting denaturation time in PCR or simply enable enrichment of minor DNA alleles by limiting the denaturation time in PCR |
| SMT202000531T1 (it) | 2014-03-09 | 2020-11-10 | Univ Pennsylvania | Composizioni utili in trattamento di deficit di ornitina transcarbamilasi(otc) |
| WO2018111835A1 (en) | 2016-12-12 | 2018-06-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for molecular barcoding of dna molecules prior to mutation enrichment and/or mutation detection |
| US11174511B2 (en) | 2017-07-24 | 2021-11-16 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for selecting and amplifying DNA targets in a single reaction mixture |
| WO2025049432A1 (en) * | 2023-08-28 | 2025-03-06 | Intellia Therapeutics, Inc. | Methods for editing hla-a in cells pre-screened for the absence of one or both alleles of hla-h*01 |
| CN118207338B (zh) * | 2024-05-20 | 2024-09-13 | 杭州迪谱医学检验实验室有限公司 | 一种基于核酸质谱的多重超敏体细胞突变检测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE66572B1 (en) * | 1989-02-13 | 1996-01-24 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
| US5702885A (en) * | 1990-06-27 | 1997-12-30 | The Blood Center Research Foundation, Inc. | Method for HLA typing |
| CA2115342C (en) * | 1992-06-17 | 2003-08-26 | Robert B. Wallace | A method of detecting and discriminating between nucleic acid sequences |
| GB9503808D0 (en) * | 1995-02-24 | 1995-04-12 | Univ Nottingham | Detection assay |
| EP2332957B1 (en) * | 1996-02-09 | 2015-04-08 | Cornell Research Foundation, Inc. | Detection of nucleic and acid sequence differences using the ligase detection reaction with addressable arrays |
| WO1998013527A2 (en) * | 1996-09-24 | 1998-04-02 | Rapigene, Inc. | Compositions and methods for enhancing hybridization specificity |
-
2001
- 2001-08-30 WO PCT/US2001/041956 patent/WO2002018659A2/en not_active Ceased
- 2001-08-30 CN CNB018183670A patent/CN1293204C/zh not_active Expired - Fee Related
- 2001-08-30 CA CA002421078A patent/CA2421078A1/en not_active Abandoned
- 2001-08-30 JP JP2002522564A patent/JP2004520812A/ja not_active Withdrawn
- 2001-08-30 AU AU2001289177A patent/AU2001289177A1/en not_active Abandoned
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