JP2004518639A - 塩化物分泌を増加しそして炎症を阻害するためのイノシトール誘導体 - Google Patents

塩化物分泌を増加しそして炎症を阻害するためのイノシトール誘導体 Download PDF

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JP2004518639A
JP2004518639A JP2002544012A JP2002544012A JP2004518639A JP 2004518639 A JP2004518639 A JP 2004518639A JP 2002544012 A JP2002544012 A JP 2002544012A JP 2002544012 A JP2002544012 A JP 2002544012A JP 2004518639 A JP2004518639 A JP 2004518639A
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JP2004518639A5 (https=
Inventor
アレクシス トレイナー−カプラン，
カーステン シュルツ，
ターニャ マイヤーディルクス，
マーク ムーディ，
アンドリュー シュナーズ，
ジェーン スミス，
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イノロジック， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
    • C07F9/65527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2002544012A 2000-11-21 2001-11-21 塩化物分泌を増加しそして炎症を阻害するためのイノシトール誘導体 Pending JP2004518639A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25260300P 2000-11-21 2000-11-21
PCT/US2001/043664 WO2002041831A2 (en) 2000-11-21 2001-11-21 Inositol derivatives for increasing chloride secretion and inhibiting inflammation

Publications (2)

Publication Number Publication Date
JP2004518639A true JP2004518639A (ja) 2004-06-24
JP2004518639A5 JP2004518639A5 (https=) 2005-12-22

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ID=22956721

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JP2002544012A Pending JP2004518639A (ja) 2000-11-21 2001-11-21 塩化物分泌を増加しそして炎症を阻害するためのイノシトール誘導体

Country Status (6)

Country Link
US (1) US7453006B2 (https=)
EP (1) EP1345950A4 (https=)
JP (1) JP2004518639A (https=)
AU (1) AU2002217808A1 (https=)
CA (1) CA2430190A1 (https=)
WO (1) WO2002041831A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008535804A (ja) * 2005-03-18 2008-09-04 オキシプラス インコーポレイテッド ヘモグロビンのアロステリックエフェクターとしてのミオイノシトール１，６：２，３：４，５トリピロリン酸のカルシウム塩

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
AU2002327006A1 (en) * 2001-09-20 2003-04-01 Inologic, Inc. Method of modulating sodium ion absorption in epithelial cells
US7084115B2 (en) 2002-04-29 2006-08-01 Oxyplus, Inc. Inositol pyrophosphates, and methods of use thereof
JPWO2004075906A1 (ja) * 2003-02-26 2006-06-01 リジェンティス株式会社 抗炎症剤及び抗炎症性医療材料
US20060258626A1 (en) * 2004-07-06 2006-11-16 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
US20060106000A1 (en) * 2004-07-06 2006-05-18 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
US7745423B2 (en) * 2004-07-06 2010-06-29 NormOxys, Inc Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
CN101505763A (zh) * 2006-06-09 2009-08-12 鹿特丹伊拉斯姆斯大学医疗中心 通过肌醇磷脂调节免疫系统
CN101784193A (zh) * 2007-05-01 2010-07-21 诺尔姆奥克西斯公司 促红细胞生成素互补或替代
EP2485786B1 (en) 2009-10-08 2020-08-19 SHL Medical AG Medicament delivery device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8605063D0 (sv) 1986-11-26 1986-11-26 Matti Siren Derivatives of cyclohexane
FR2694936B1 (fr) * 1992-08-18 1994-11-25 Bayer Pharma Dérivés substitués du désoxy-myoinositol, procédé pour leur préparation et leur utilisation dans des médicaments.
SE503122C2 (sv) * 1993-11-22 1996-03-25 Perstorp Ab Användning av en inositoltrisfosfatester för behandling av inflammatoriska tillstånd
US5977078A (en) 1996-09-20 1999-11-02 The Regents Of The Univesity Of California Inositol polyphosphate derivatives and methods of using same
CN1145489C (zh) * 1996-09-20 2004-04-14 加利福尼亚大学董事会 肌醇多磷酸酯衍生物及其使用方法
US6221856B1 (en) 1999-02-03 2001-04-24 Inologic, Inc. Inositol derivatives for inhibiting superoxide anion production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008535804A (ja) * 2005-03-18 2008-09-04 オキシプラス インコーポレイテッド ヘモグロビンのアロステリックエフェクターとしてのミオイノシトール１，６：２，３：４，５トリピロリン酸のカルシウム塩

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Publication number Publication date
US7453006B2 (en) 2008-11-18
US20040147487A1 (en) 2004-07-29
WO2002041831A2 (en) 2002-05-30
EP1345950A2 (en) 2003-09-24
EP1345950A4 (en) 2005-04-27
CA2430190A1 (en) 2002-05-30
AU2002217808A1 (en) 2002-06-03
WO2002041831A3 (en) 2002-07-18

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