JP2004517810A - 片頭痛の処置のためのプロポフォールの水溶性プロドラッグ - Google Patents

片頭痛の処置のためのプロポフォールの水溶性プロドラッグ Download PDF

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Publication number
JP2004517810A
JP2004517810A JP2002518956A JP2002518956A JP2004517810A JP 2004517810 A JP2004517810 A JP 2004517810A JP 2002518956 A JP2002518956 A JP 2002518956A JP 2002518956 A JP2002518956 A JP 2002518956A JP 2004517810 A JP2004517810 A JP 2004517810A
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JP
Japan
Prior art keywords
propofol
migraine
pharmaceutically acceptable
water
composition
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2002518956A
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English (en)
Japanese (ja)
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JP2004517810A5 (https=
Inventor
エス． ヘンドラー，シェルドン
Original Assignee
バイレックス コーポレイション
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Application filed by バイレックス コーポレイション filed Critical バイレックス コーポレイション
Publication of JP2004517810A publication Critical patent/JP2004517810A/ja
Publication of JP2004517810A5 publication Critical patent/JP2004517810A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002518956A 2000-08-15 2001-08-14 片頭痛の処置のためのプロポフォールの水溶性プロドラッグ Pending JP2004517810A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/639,015 US6362234B1 (en) 2000-08-15 2000-08-15 Water-soluble prodrugs of propofol for treatment of migrane
PCT/US2001/025540 WO2002013810A1 (en) 2000-08-15 2001-08-14 Water-soluble prodrugs of propofol for treatment of migraine

Publications (2)

Publication Number Publication Date
JP2004517810A true JP2004517810A (ja) 2004-06-17
JP2004517810A5 JP2004517810A5 (https=) 2008-10-02

Family

ID=24562380

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002518956A Pending JP2004517810A (ja) 2000-08-15 2001-08-14 片頭痛の処置のためのプロポフォールの水溶性プロドラッグ

Country Status (5)

Country Link
US (1) US6362234B1 (https=)
EP (1) EP1318798A4 (https=)
JP (1) JP2004517810A (https=)
CA (1) CA2419047A1 (https=)
WO (1) WO2002013810A1 (https=)

Cited By (2)

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JP2011173999A (ja) * 2010-02-25 2011-09-08 Shin-Etsu Chemical Co Ltd リン酸エステル基含有オルガノポリシロキサン及びその製造方法
JP2011195719A (ja) * 2010-03-19 2011-10-06 Shin-Etsu Chemical Co Ltd リン酸エステル基含有オルガノポリシロキサンの製造方法

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US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
ES2211151T3 (es) * 1998-08-19 2004-07-01 Skyepharma Canada Inc. Dispersiones acuosas inyectables de propofol.
JP4334229B2 (ja) * 2001-03-20 2009-09-30 サイデックス・ファーマシューティカルズ・インコーポレイテッド プロポフォール及びスルホアルキルエーテルシクロデキストリン含有製剤
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
PL205271B1 (pl) * 2001-12-28 2010-03-31 Mgi Gp Kompozycja farmaceutyczna rozpuszczalnego w wodzie proleku propofolu
EP1490030B2 (en) * 2002-03-20 2010-07-14 Elan Pharma International Limited Nanoparticulate compositions of angiogenesis inhibitors
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
CA2480881C (en) * 2002-04-08 2012-09-11 Guilford Pharmaceuticals, Inc. Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same
AU2002950713A0 (en) 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
DE20215415U1 (de) * 2002-10-08 2004-02-26 Biotechnologie Gesellschaft Mittelhessen Mbh Wasserlösliche Medikamentenvorstufen von Propofol
CN103405405A (zh) * 2002-12-09 2013-11-27 阿布拉西斯生物科学有限责任公司 组合物和传递药剂的方法
ZA200504940B (en) * 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
US8476010B2 (en) 2003-07-10 2013-07-02 App Pharmaceuticals Llc Propofol formulations with non-reactive container closures
US7230003B2 (en) * 2003-09-09 2007-06-12 Xenoport, Inc. Aromatic prodrugs of propofol, compositions and uses thereof
CN1882548A (zh) * 2003-10-24 2006-12-20 奥斯佩克斯制药公司 2,6－二异丙基苯酚的pH敏感性前药
WO2005058250A2 (en) * 2003-12-17 2005-06-30 Mgi Gp, Inc. Methods of administering water-soluble prodrugs of propofol for extended sedation
WO2006017351A1 (en) 2004-07-12 2006-02-16 Xenoport, Inc. Prodrugs of propofol, compositions and uses thereof
CA2571407A1 (en) * 2004-07-12 2006-02-16 Xenoport, Inc. Amino acid derived prodrugs of propofol, compositions and uses thereof
US20080214508A1 (en) * 2004-09-17 2008-09-04 Mgi Gp, Inc. Methods of Administering Water-Soluble Prodrugs of Propofol
EP1844000B1 (en) * 2004-12-23 2010-01-27 Xenoport, Inc. Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
NZ565049A (en) 2005-06-17 2012-02-24 Vital Health Sciences Pty Ltd A carrier comprising one or more DI and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
WO2007022437A2 (en) * 2005-08-18 2007-02-22 Auspex Pharmaceuticals, Inc. Therapeutic agents for the treatment of cancer and metabolic disorders
WO2007028104A2 (en) * 2005-09-02 2007-03-08 Auspex Pharmaceuticals, Inc. Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2008052044A2 (en) * 2006-10-26 2008-05-02 Xenoport, Inc. Use of derivatives of propofol for treating diseases associated with oxidative stress
BRPI0811220A2 (pt) 2007-05-09 2014-10-29 Pharmacofore Inc Compostos terapêuticos
MX2009012125A (es) 2007-05-09 2010-02-18 Pharmacofore Inc Compuestos terapeuticos.
US20090005444A1 (en) * 2007-06-21 2009-01-01 Xenoport, Inc. Use of propofol prodrugs for treating alcohol withdrawal, central pain, anxiety or pruritus
WO2009036322A1 (en) * 2007-09-14 2009-03-19 Xenoport, Inc. Use of propofol prodrugs for treating neuropathic pain
GB0905834D0 (en) 2009-04-03 2009-05-20 Seps Pharma Nv Phosphonyl-containing phenolic derivatives useful as medicaments
CN101575349B (zh) * 2009-06-11 2011-07-20 中国科学院广州化学研究所 一种丙泊酚磷酸酯二钠盐的制备方法
ES2999020T3 (en) 2010-02-05 2025-02-24 Phosphagenics Ltd Carrier comprising non-neutralised tocopheryl phosphate
EP2552486B1 (en) 2010-03-30 2020-08-12 Phosphagenics Limited Transdermal delivery patch
CN101885735B (zh) * 2010-06-23 2012-09-12 四川大学华西医院 取代苯酚羟基酸酯的磷酸酯化合物、制备方法及在药物中的应用
WO2011161687A1 (en) 2010-06-23 2011-12-29 Harman Finochem Limited Process for preparing extra pure 2, 6-diisopropyl phenol
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
CN102260184B (zh) * 2011-06-09 2014-07-02 浙江九旭药业有限公司 丙泊酚衍生物及其制备方法和应用
CN114712308A (zh) 2015-12-09 2022-07-08 磷肌酸有限公司 药物制剂
US11331271B2 (en) 2016-05-27 2022-05-17 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
EP3558903B1 (en) 2016-12-21 2024-07-03 Avecho Biotechnology Limited Process for phosphorylating a complex alcohol
US11478490B1 (en) 2021-03-30 2022-10-25 Epalex Corporation Fospropofol formulations
US11628178B2 (en) 2019-03-26 2023-04-18 Epalex Corporation Fospropofol methods and compositions
US11547714B2 (en) 2020-02-05 2023-01-10 Epalex Corporation Fospropofol salts, methods and compositions
US11439653B1 (en) 2021-03-30 2022-09-13 Epalex Corporation Fospropofol formulations
JP7751569B2 (ja) 2019-10-22 2025-10-08 ウェストチャイナホスピタル、スーチョワンユニバーシティ 置換フェノールヒドロキシ酸エステルのｎ含有誘導体、製造及び使用
EP3912621A1 (en) * 2020-05-19 2021-11-24 tesa Labtec GmbH Propofol for diagnosis of primary headache

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058555A2 (en) * 1998-05-08 1999-11-18 Vyrex Corporation Water-soluble pro-drugs of 2,6-diisopropylphenol analogues

Family Cites Families (4)

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US5767117A (en) * 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
JPH08339002A (ja) * 1995-04-10 1996-12-24 Ngk Insulators Ltd 第二高調波発生素子およびその製造方法
US5891875A (en) * 1996-05-20 1999-04-06 Eli Lilly And Company Morpholinyl tachykinin receptor antagonists
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058555A2 (en) * 1998-05-08 1999-11-18 Vyrex Corporation Water-soluble pro-drugs of 2,6-diisopropylphenol analogues

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011173999A (ja) * 2010-02-25 2011-09-08 Shin-Etsu Chemical Co Ltd リン酸エステル基含有オルガノポリシロキサン及びその製造方法
JP2011195719A (ja) * 2010-03-19 2011-10-06 Shin-Etsu Chemical Co Ltd リン酸エステル基含有オルガノポリシロキサンの製造方法

Also Published As

Publication number Publication date
EP1318798A4 (en) 2004-01-28
WO2002013810A1 (en) 2002-02-21
CA2419047A1 (en) 2002-02-21
US6362234B1 (en) 2002-03-26
EP1318798A1 (en) 2003-06-18

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