JP2004517071A5 - - Google Patents

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JP2004517071A5
JP2004517071A5 JP2002543503A JP2002543503A JP2004517071A5 JP 2004517071 A5 JP2004517071 A5 JP 2004517071A5 JP 2002543503 A JP2002543503 A JP 2002543503A JP 2002543503 A JP2002543503 A JP 2002543503A JP 2004517071 A5 JP2004517071 A5 JP 2004517071A5
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Japan
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during crystallization
stability
adjusting
results
product
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JP2002543503A
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JP4560637B2 (ja
JP2004517071A (ja
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Priority claimed from PCT/US2001/043491 external-priority patent/WO2002040495A2/en
Publication of JP2004517071A publication Critical patent/JP2004517071A/ja
Publication of JP2004517071A5 publication Critical patent/JP2004517071A5/ja
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Publication of JP4560637B2 publication Critical patent/JP4560637B2/ja
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Description

実施例２
結晶化中の生成物の安定性に対するｐＨの影響
結晶化中に存在するアセテートまたは他の緩衝物質の量に関わらず、母液のｐＨは時間が経つと下降する傾向がある。従来から、ｐＨは約３乃至約４の範囲を有する。我々は結晶化中にｐＨを中性付近に調整すると、最終生成物の安定性が極めて高くなることを発見した。次の表は、結晶化中にｐＨを変化させた種々のバッチの安定性の結果を示す。
Figure 2004517071
 中性付近（約６乃至約８）にｐＨを調整することによって、安定化を促進した試験環境の下で平均的な安定性を著しく高めることができることがデータから明らかである。
JP2002543503A 2000-11-17 2001-11-16 改良されたスクラロース組成物およびその結晶化の方法 Expired - Fee Related JP4560637B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24978200P 2000-11-17 2000-11-17
PCT/US2001/043491 WO2002040495A2 (en) 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof

Related Child Applications (1)

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JP2009188092A Division JP2009298803A (ja) 2000-11-17 2009-08-14 改良されたスクラロース組成物およびその結晶化の方法

Publications (3)

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JP2004517071A JP2004517071A (ja) 2004-06-10
JP2004517071A5 true JP2004517071A5 (ja) 2009-11-05
JP4560637B2 JP4560637B2 (ja) 2010-10-13

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JP2002543503A Expired - Fee Related JP4560637B2 (ja) 2000-11-17 2001-11-16 改良されたスクラロース組成物およびその結晶化の方法
JP2009188092A Pending JP2009298803A (ja) 2000-11-17 2009-08-14 改良されたスクラロース組成物およびその結晶化の方法

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JP2009188092A Pending JP2009298803A (ja) 2000-11-17 2009-08-14 改良されたスクラロース組成物およびその結晶化の方法

Country Status (11)

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US (4) US6646121B2 (ja)
EP (1) EP1339728B1 (ja)
JP (2) JP4560637B2 (ja)
KR (1) KR100854528B1 (ja)
CN (1) CN1294139C (ja)
AU (2) AU2691802A (ja)
BR (1) BR0115482B1 (ja)
CA (1) CA2429228C (ja)
MX (1) MXPA03004402A (ja)
RU (1) RU2279437C2 (ja)
WO (1) WO2002040495A2 (ja)

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